| Full name: alkaline phosphatase, placental | Alias Symbol: PALP|PLAP | ||
| Type: protein-coding gene | Cytoband: 2q37.1 | ||
| Entrez ID: 250 | HGNC ID: HGNC:439 | Ensembl Gene: ENSG00000163283 | OMIM ID: 171800 |
| Drug and gene relationship at DGIdb | |||
Expression of ALPP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALPP | 250 | 204664_at | 0.1556 | 0.7847 | |
| GSE20347 | ALPP | 250 | 204664_at | -0.0919 | 0.3147 | |
| GSE23400 | ALPP | 250 | 204664_at | -0.2295 | 0.0000 | |
| GSE26886 | ALPP | 250 | 204664_at | 0.0692 | 0.6833 | |
| GSE29001 | ALPP | 250 | 204664_at | -0.3984 | 0.0074 | |
| GSE38129 | ALPP | 250 | 204664_at | -0.1084 | 0.0918 | |
| GSE45670 | ALPP | 250 | 204664_at | 0.1703 | 0.0900 | |
| GSE53622 | ALPP | 250 | 58647 | 0.4259 | 0.0002 | |
| GSE53624 | ALPP | 250 | 58647 | 0.2312 | 0.0569 | |
| GSE63941 | ALPP | 250 | 204664_at | 0.8189 | 0.5277 | |
| GSE77861 | ALPP | 250 | 204664_at | -0.1129 | 0.2664 | |
| GSE97050 | ALPP | 250 | A_23_P79587 | -0.3128 | 0.2832 | |
| TCGA | ALPP | 250 | RNAseq | 2.9651 | 0.0145 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ALPP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALPP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALPP | 250 | 1 | 12 | 17 | |
| GSE20123 | ALPP | 250 | 1 | 12 | 17 | |
| GSE43470 | ALPP | 250 | 1 | 8 | 34 | |
| GSE46452 | ALPP | 250 | 0 | 5 | 54 | |
| GSE47630 | ALPP | 250 | 4 | 5 | 31 | |
| GSE54993 | ALPP | 250 | 2 | 2 | 66 | |
| GSE54994 | ALPP | 250 | 6 | 10 | 37 | |
| GSE60625 | ALPP | 250 | 0 | 3 | 8 | |
| GSE74703 | ALPP | 250 | 1 | 6 | 29 | |
| GSE74704 | ALPP | 250 | 1 | 5 | 14 | |
| TCGA | ALPP | 250 | 12 | 28 | 56 |
Total number of gains: 29; Total number of losses: 96; Total Number of normals: 363.
Somatic mutations of ALPP:
Generating mutation plots.
Highly correlated genes for ALPP:
Showing top 20/501 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALPP | STRC | 0.823366 | 3 | 0 | 3 |
| ALPP | CELF5 | 0.795434 | 3 | 0 | 3 |
| ALPP | SLC6A3 | 0.77528 | 4 | 0 | 4 |
| ALPP | OR2T27 | 0.773282 | 3 | 0 | 3 |
| ALPP | SYCN | 0.770286 | 3 | 0 | 3 |
| ALPP | DCDC1 | 0.767388 | 3 | 0 | 3 |
| ALPP | LMOD3 | 0.76379 | 3 | 0 | 3 |
| ALPP | ZNF527 | 0.755653 | 3 | 0 | 3 |
| ALPP | CSH2 | 0.755172 | 3 | 0 | 3 |
| ALPP | ASTL | 0.733185 | 3 | 0 | 3 |
| ALPP | LRRC71 | 0.731377 | 3 | 0 | 3 |
| ALPP | CC2D1B | 0.723064 | 3 | 0 | 3 |
| ALPP | MRPS16 | 0.722287 | 3 | 0 | 3 |
| ALPP | OR2A5 | 0.721359 | 3 | 0 | 3 |
| ALPP | OR4D6 | 0.719889 | 3 | 0 | 3 |
| ALPP | ZNF526 | 0.718254 | 4 | 0 | 4 |
| ALPP | OR1J4 | 0.715289 | 3 | 0 | 3 |
| ALPP | KRTAP10-12 | 0.712088 | 3 | 0 | 3 |
| ALPP | VHL | 0.710968 | 5 | 0 | 4 |
| ALPP | GGT1 | 0.708507 | 3 | 0 | 3 |
For details and further investigation, click here
