| Full name: keratin 74 | Alias Symbol: K6IRS4|KRT5C|KRT6IRS4 | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 121391 | HGNC ID: HGNC:28929 | Ensembl Gene: ENSG00000170484 | OMIM ID: 608248 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of KRT74:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KRT74 | 121391 | 1553539_at | -0.2098 | 0.3387 | |
| GSE26886 | KRT74 | 121391 | 231583_at | 0.2711 | 0.0788 | |
| GSE45670 | KRT74 | 121391 | 1553539_at | -0.0344 | 0.7536 | |
| GSE53622 | KRT74 | 121391 | 92826 | 0.3174 | 0.0006 | |
| GSE53624 | KRT74 | 121391 | 92826 | 0.0524 | 0.7050 | |
| GSE63941 | KRT74 | 121391 | 231583_at | 0.3306 | 0.1380 | |
| GSE77861 | KRT74 | 121391 | 1553539_at | -0.2701 | 0.0540 | |
| GSE97050 | KRT74 | 121391 | A_33_P3315284 | 0.0073 | 0.9925 | |
| SRP159526 | KRT74 | 121391 | RNAseq | 3.2798 | 0.0000 | |
| TCGA | KRT74 | 121391 | RNAseq | 2.5961 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by KRT74 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KRT74:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KRT74 | 121391 | 8 | 1 | 21 | |
| GSE20123 | KRT74 | 121391 | 8 | 1 | 21 | |
| GSE43470 | KRT74 | 121391 | 3 | 0 | 40 | |
| GSE46452 | KRT74 | 121391 | 7 | 1 | 51 | |
| GSE47630 | KRT74 | 121391 | 10 | 2 | 28 | |
| GSE54993 | KRT74 | 121391 | 0 | 5 | 65 | |
| GSE54994 | KRT74 | 121391 | 5 | 1 | 47 | |
| GSE60625 | KRT74 | 121391 | 0 | 0 | 11 | |
| GSE74703 | KRT74 | 121391 | 3 | 0 | 33 | |
| GSE74704 | KRT74 | 121391 | 5 | 1 | 14 | |
| TCGA | KRT74 | 121391 | 13 | 11 | 72 |
Total number of gains: 62; Total number of losses: 23; Total Number of normals: 403.
Somatic mutations of KRT74:
Generating mutation plots.
Highly correlated genes for KRT74:
Showing top 20/319 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KRT74 | OR2T27 | 0.7914 | 3 | 0 | 3 |
| KRT74 | PLA2G2C | 0.776606 | 3 | 0 | 3 |
| KRT74 | KRT35 | 0.772387 | 4 | 0 | 4 |
| KRT74 | FMR1NB | 0.770302 | 3 | 0 | 3 |
| KRT74 | CCL17 | 0.768803 | 3 | 0 | 3 |
| KRT74 | ZNF527 | 0.765747 | 3 | 0 | 3 |
| KRT74 | OR5A1 | 0.761417 | 3 | 0 | 3 |
| KRT74 | ENTPD5 | 0.758321 | 3 | 0 | 3 |
| KRT74 | MOS | 0.757394 | 3 | 0 | 3 |
| KRT74 | YY2 | 0.755194 | 3 | 0 | 3 |
| KRT74 | CRTAC1 | 0.751687 | 3 | 0 | 3 |
| KRT74 | TULP1 | 0.750264 | 3 | 0 | 3 |
| KRT74 | STRC | 0.748846 | 3 | 0 | 3 |
| KRT74 | MRGPRG | 0.748676 | 3 | 0 | 3 |
| KRT74 | PYDC1 | 0.74693 | 3 | 0 | 3 |
| KRT74 | MUC2 | 0.746667 | 3 | 0 | 3 |
| KRT74 | CPLX2 | 0.744542 | 3 | 0 | 3 |
| KRT74 | GRIK4 | 0.739091 | 3 | 0 | 3 |
| KRT74 | PSMB11 | 0.734995 | 3 | 0 | 3 |
| KRT74 | GCM2 | 0.733063 | 3 | 0 | 3 |
For details and further investigation, click here
