ASXL2

 

Full name: ASXL transcriptional regulator 2 Alias Symbol: ASXH2|FLJ10898|KIAA1685
Type: protein-coding gene Cytoband: 2p23.3
Entrez ID: 55252 HGNC ID: HGNC:23805 Ensembl Gene: ENSG00000143970 OMIM ID: 612991
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ASXL2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ASXL2 55252 218659_at 0.4876 0.1476
GSE20347 ASXL2 55252 218659_at 0.0045 0.9808
GSE23400 ASXL2 55252 218659_at 0.2180 0.0004
GSE26886 ASXL2 55252 218659_at 0.7921 0.0015
GSE29001 ASXL2 55252 218659_at 0.0344 0.9103
GSE38129 ASXL2 55252 218659_at 0.0074 0.9817
GSE45670 ASXL2 55252 218659_at 0.1898 0.0341
GSE53622 ASXL2 55252 100787 0.0553 0.2611
GSE53624 ASXL2 55252 100787 0.0485 0.3673
GSE63941 ASXL2 55252 218659_at 1.8238 0.0005
GSE77861 ASXL2 55252 218659_at 0.3630 0.0785
GSE97050 ASXL2 55252 A_23_P210300 0.0691 0.7635
SRP007169 ASXL2 55252 RNAseq 1.3753 0.0002
SRP008496 ASXL2 55252 RNAseq 1.2444 0.0000
SRP064894 ASXL2 55252 RNAseq 0.0245 0.9227
SRP133303 ASXL2 55252 RNAseq 0.2595 0.0129
SRP159526 ASXL2 55252 RNAseq 0.1102 0.6789
SRP193095 ASXL2 55252 RNAseq 0.2059 0.0247
SRP219564 ASXL2 55252 RNAseq 0.0211 0.9223
TCGA ASXL2 55252 RNAseq -0.0043 0.9546

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by ASXL2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ASXL2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ASXL2 55252 11 2 17
GSE20123 ASXL2 55252 11 2 17
GSE43470 ASXL2 55252 3 1 39
GSE46452 ASXL2 55252 3 4 52
GSE47630 ASXL2 55252 8 0 32
GSE54993 ASXL2 55252 0 6 64
GSE54994 ASXL2 55252 10 0 43
GSE60625 ASXL2 55252 0 3 8
GSE74703 ASXL2 55252 3 0 33
GSE74704 ASXL2 55252 9 1 10
TCGA ASXL2 55252 37 4 55

Total number of gains: 95; Total number of losses: 23; Total Number of normals: 370.  

 

Somatic mutations of ASXL2:

 

Generating mutation plots.

 

Highly correlated genes for ASXL2:

 

Showing top 20/1042 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ASXL2AK20.802849303
ASXL2SDR39U10.780328303
ASXL2GATAD2B0.774525303
ASXL2ZNF7660.762803303
ASXL2ELOVL70.762404303
ASXL2LY750.755054303
ASXL2HERPUD20.752698303
ASXL2PET1170.752422303
ASXL2NSMCE20.746572303
ASXL2CD1640.742209403
ASXL2DDX200.740865404
ASXL2DMXL20.739615303
ASXL2RNF130.737085505
ASXL2ANAPC160.732347303
ASXL2RICTOR0.732112303
ASXL2NOL90.731979403
ASXL2IRS20.731353303
ASXL2TFDP20.728147403
ASXL2PIBF10.72476303
ASXL2CWF19L10.724101303

For details and further investigation, click here