| Full name: adenylate kinase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p35.1 | ||
| Entrez ID: 204 | HGNC ID: HGNC:362 | Ensembl Gene: ENSG00000004455 | OMIM ID: 103020 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of AK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AK2 | 204 | 208967_s_at | 0.0622 | 0.8690 | |
| GSE20347 | AK2 | 204 | 208967_s_at | -0.0045 | 0.9835 | |
| GSE23400 | AK2 | 204 | 208967_s_at | 0.2862 | 0.0001 | |
| GSE26886 | AK2 | 204 | 212175_s_at | -0.8010 | 0.0027 | |
| GSE29001 | AK2 | 204 | 212175_s_at | 0.2500 | 0.2709 | |
| GSE38129 | AK2 | 204 | 208967_s_at | 0.2580 | 0.0400 | |
| GSE45670 | AK2 | 204 | 212175_s_at | 0.3696 | 0.0272 | |
| GSE53622 | AK2 | 204 | 1832 | -0.1599 | 0.0010 | |
| GSE53624 | AK2 | 204 | 1832 | 0.3497 | 0.0000 | |
| GSE63941 | AK2 | 204 | 212175_s_at | 1.8027 | 0.0002 | |
| GSE77861 | AK2 | 204 | 208967_s_at | -0.0596 | 0.8860 | |
| GSE97050 | AK2 | 204 | A_24_P179903 | 0.0160 | 0.9610 | |
| SRP007169 | AK2 | 204 | RNAseq | -0.5101 | 0.1106 | |
| SRP008496 | AK2 | 204 | RNAseq | -0.6949 | 0.0004 | |
| SRP064894 | AK2 | 204 | RNAseq | 0.3415 | 0.1265 | |
| SRP133303 | AK2 | 204 | RNAseq | 0.2029 | 0.0976 | |
| SRP159526 | AK2 | 204 | RNAseq | 0.0032 | 0.9880 | |
| SRP193095 | AK2 | 204 | RNAseq | -0.1680 | 0.0946 | |
| SRP219564 | AK2 | 204 | RNAseq | -0.1844 | 0.5254 | |
| TCGA | AK2 | 204 | RNAseq | 0.1224 | 0.0102 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by AK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AK2 | 204 | 2 | 5 | 23 | |
| GSE20123 | AK2 | 204 | 2 | 4 | 24 | |
| GSE43470 | AK2 | 204 | 5 | 6 | 32 | |
| GSE46452 | AK2 | 204 | 5 | 1 | 53 | |
| GSE47630 | AK2 | 204 | 8 | 3 | 29 | |
| GSE54993 | AK2 | 204 | 1 | 1 | 68 | |
| GSE54994 | AK2 | 204 | 11 | 2 | 40 | |
| GSE60625 | AK2 | 204 | 0 | 0 | 11 | |
| GSE74703 | AK2 | 204 | 4 | 3 | 29 | |
| GSE74704 | AK2 | 204 | 1 | 0 | 19 | |
| TCGA | AK2 | 204 | 12 | 18 | 66 |
Total number of gains: 51; Total number of losses: 43; Total Number of normals: 394.
Somatic mutations of AK2:
Generating mutation plots.
Highly correlated genes for AK2:
Showing top 20/581 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AK2 | ASXL2 | 0.802849 | 3 | 0 | 3 |
| AK2 | PRPS2 | 0.794484 | 3 | 0 | 3 |
| AK2 | TCEANC2 | 0.750519 | 3 | 0 | 3 |
| AK2 | LPAR6 | 0.734259 | 3 | 0 | 3 |
| AK2 | IMPACT | 0.734008 | 4 | 0 | 3 |
| AK2 | SPTLC2 | 0.730631 | 4 | 0 | 4 |
| AK2 | SLC10A7 | 0.729847 | 3 | 0 | 3 |
| AK2 | NUS1 | 0.727369 | 3 | 0 | 3 |
| AK2 | EBAG9 | 0.724811 | 3 | 0 | 3 |
| AK2 | EBNA1BP2 | 0.719406 | 3 | 0 | 3 |
| AK2 | MAL2 | 0.716281 | 3 | 0 | 3 |
| AK2 | PPWD1 | 0.713156 | 4 | 0 | 4 |
| AK2 | STX17 | 0.708899 | 3 | 0 | 3 |
| AK2 | EXOSC10 | 0.708856 | 4 | 0 | 3 |
| AK2 | NOLC1 | 0.704035 | 5 | 0 | 5 |
| AK2 | PLS1 | 0.6997 | 4 | 0 | 3 |
| AK2 | ZMYM6 | 0.698652 | 4 | 0 | 3 |
| AK2 | RNF145 | 0.698261 | 4 | 0 | 3 |
| AK2 | FYTTD1 | 0.696365 | 4 | 0 | 4 |
| AK2 | RPP40 | 0.694384 | 4 | 0 | 3 |
For details and further investigation, click here
