IRS2

 

Full name: insulin receptor substrate 2 Alias Symbol: 
Type: protein-coding gene Cytoband: 13q34
Entrez ID: 8660 HGNC ID: HGNC:6126 Ensembl Gene: ENSG00000185950 OMIM ID: 600797
Drug and gene relationship at DGIdb
Screen Evidence:

 

IRS2 involved pathways:

KEGG pathway Description View
hsa04022cGMP-PKG signaling pathway
hsa04068FoxO signaling pathway
hsa04152AMPK signaling pathway
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04930Type II diabetes mellitus
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)

 

Expression of IRS2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IRS2 8660 209185_s_at -0.9197 0.3093
GSE20347 IRS2 8660 209185_s_at 0.7350 0.1235
GSE23400 IRS2 8660 209185_s_at 0.2519 0.1416
GSE26886 IRS2 8660 209185_s_at 2.6430 0.0000
GSE29001 IRS2 8660 209185_s_at 0.0214 0.9673
GSE38129 IRS2 8660 209185_s_at 0.4610 0.1887
GSE45670 IRS2 8660 209185_s_at -1.1046 0.0319
GSE53622 IRS2 8660 118225 -0.0137 0.9409
GSE53624 IRS2 8660 118225 0.2697 0.0668
GSE63941 IRS2 8660 209185_s_at -1.5803 0.1662
GSE77861 IRS2 8660 209185_s_at 1.5065 0.0123
GSE97050 IRS2 8660 A_24_P154037 -1.0070 0.1218
SRP007169 IRS2 8660 RNAseq 1.4036 0.0090
SRP008496 IRS2 8660 RNAseq 1.0721 0.0200
SRP064894 IRS2 8660 RNAseq 0.3284 0.2052
SRP133303 IRS2 8660 RNAseq 0.1825 0.5919
SRP159526 IRS2 8660 RNAseq 0.5808 0.2638
SRP193095 IRS2 8660 RNAseq 0.6889 0.0171
SRP219564 IRS2 8660 RNAseq 1.0675 0.0429
TCGA IRS2 8660 RNAseq -0.1782 0.0805

Upregulated datasets: 5; Downregulated datasets: 1.  

 

Survival by IRS2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IRS2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IRS2 8660 7 11 12
GSE20123 IRS2 8660 7 10 13
GSE43470 IRS2 8660 4 13 26
GSE46452 IRS2 8660 2 31 26
GSE47630 IRS2 8660 3 26 11
GSE54993 IRS2 8660 11 4 55
GSE54994 IRS2 8660 8 8 37
GSE60625 IRS2 8660 0 3 8
GSE74703 IRS2 8660 3 9 24
GSE74704 IRS2 8660 4 9 7
TCGA IRS2 8660 19 33 44

Total number of gains: 68; Total number of losses: 157; Total Number of normals: 263.  

 

Somatic mutations of IRS2:

 

Generating mutation plots.

 

Highly correlated genes for IRS2:

 

Showing top 20/809 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IRS2RAD23A0.838236303
IRS2MYADM0.773998404
IRS2ZNF8050.765274303
IRS2TPPP30.764777303
IRS2GOPC0.764559303
IRS2MUS810.759155303
IRS2MACROD20.757816303
IRS2FUNDC20.749514403
IRS2RNASE40.746046404
IRS2KIAA0895L0.744894303
IRS2MSI20.744484404
IRS2GPR30.74391303
IRS2EIF3G0.739565403
IRS2TNPO20.739179303
IRS2FHL10.732335504
IRS2IGFBP60.732058303
IRS2ASXL20.731353303
IRS2C3orf700.731071403
IRS2DPYSL30.726133705
IRS2IRF2BP20.724872403

For details and further investigation, click here