GATAD2B

 

Full name: GATA zinc finger domain containing 2B Alias Symbol: P66beta
Type: protein-coding gene Cytoband: 1q21.3
Entrez ID: 57459 HGNC ID: HGNC:30778 Ensembl Gene: ENSG00000143614 OMIM ID: 614998
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of GATAD2B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GATAD2B 57459 225393_at 0.4442 0.3141
GSE26886 GATAD2B 57459 225393_at 0.3222 0.0702
GSE45670 GATAD2B 57459 225393_at 0.1843 0.0475
GSE53622 GATAD2B 57459 89176 -0.4200 0.0011
GSE53624 GATAD2B 57459 89176 -0.2976 0.0020
GSE63941 GATAD2B 57459 225393_at 0.8402 0.0249
GSE77861 GATAD2B 57459 225393_at 0.2598 0.2125
GSE97050 GATAD2B 57459 A_33_P3323822 -0.6000 0.1113
SRP007169 GATAD2B 57459 RNAseq 0.1861 0.5478
SRP008496 GATAD2B 57459 RNAseq 0.3920 0.0605
SRP064894 GATAD2B 57459 RNAseq -0.0198 0.8961
SRP133303 GATAD2B 57459 RNAseq 0.0574 0.5725
SRP159526 GATAD2B 57459 RNAseq 0.5909 0.0878
SRP193095 GATAD2B 57459 RNAseq 0.3639 0.0001
SRP219564 GATAD2B 57459 RNAseq 0.3741 0.3528
TCGA GATAD2B 57459 RNAseq 0.0671 0.1572

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by GATAD2B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GATAD2B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GATAD2B 57459 14 0 16
GSE20123 GATAD2B 57459 14 0 16
GSE43470 GATAD2B 57459 7 2 34
GSE46452 GATAD2B 57459 2 1 56
GSE47630 GATAD2B 57459 14 0 26
GSE54993 GATAD2B 57459 0 4 66
GSE54994 GATAD2B 57459 16 0 37
GSE60625 GATAD2B 57459 0 0 11
GSE74703 GATAD2B 57459 6 1 29
GSE74704 GATAD2B 57459 7 0 13
TCGA GATAD2B 57459 38 2 56

Total number of gains: 118; Total number of losses: 10; Total Number of normals: 360.  

 

Somatic mutations of GATAD2B:

 

Generating mutation plots.

 

Highly correlated genes for GATAD2B:

 

Showing top 20/458 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GATAD2BMAP2K70.813484303
GATAD2BMRPS60.800652404
GATAD2BAKAP8L0.795014303
GATAD2BSLC22A50.785336303
GATAD2BSNRNP700.776252303
GATAD2BASXL20.774525303
GATAD2BSLC25A280.760353303
GATAD2BAHCTF10.760066303
GATAD2BSCRN10.756834303
GATAD2BFAM193A0.754942303
GATAD2BOTUD30.75301303
GATAD2BPTK20.749045303
GATAD2BWDR350.746877303
GATAD2BMED90.746232303
GATAD2BNTPCR0.742335303
GATAD2BDFFA0.742011303
GATAD2BNOC3L0.741588303
GATAD2BSTX1A0.740551303
GATAD2BTLK10.740067303
GATAD2BZNF8140.73983303

For details and further investigation, click here