| Full name: NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase | Alias Symbol: FLJ32440|MMS21|NSE2|ZMIZ7 | ||
| Type: protein-coding gene | Cytoband: 8q24.13 | ||
| Entrez ID: 286053 | HGNC ID: HGNC:26513 | Ensembl Gene: ENSG00000156831 | OMIM ID: 617246 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NSMCE2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NSMCE2 | 286053 | 226536_at | 0.3152 | 0.3617 | |
| GSE26886 | NSMCE2 | 286053 | 226536_at | 0.8469 | 0.0001 | |
| GSE45670 | NSMCE2 | 286053 | 226536_at | 0.1263 | 0.3770 | |
| GSE53622 | NSMCE2 | 286053 | 87581 | 0.5046 | 0.0000 | |
| GSE53624 | NSMCE2 | 286053 | 92616 | 0.5263 | 0.0000 | |
| GSE63941 | NSMCE2 | 286053 | 226536_at | 1.1683 | 0.0096 | |
| GSE77861 | NSMCE2 | 286053 | 226536_at | 0.1918 | 0.2809 | |
| GSE97050 | NSMCE2 | 286053 | A_23_P422794 | 0.2260 | 0.3328 | |
| SRP007169 | NSMCE2 | 286053 | RNAseq | -0.6004 | 0.0806 | |
| SRP008496 | NSMCE2 | 286053 | RNAseq | -0.3302 | 0.1936 | |
| SRP064894 | NSMCE2 | 286053 | RNAseq | 0.5269 | 0.0070 | |
| SRP133303 | NSMCE2 | 286053 | RNAseq | 0.4586 | 0.0000 | |
| SRP159526 | NSMCE2 | 286053 | RNAseq | -0.1937 | 0.4973 | |
| SRP193095 | NSMCE2 | 286053 | RNAseq | 0.1820 | 0.1197 | |
| SRP219564 | NSMCE2 | 286053 | RNAseq | -0.0511 | 0.8371 | |
| TCGA | NSMCE2 | 286053 | RNAseq | 0.2003 | 0.0032 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by NSMCE2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NSMCE2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NSMCE2 | 286053 | 20 | 0 | 10 | |
| GSE20123 | NSMCE2 | 286053 | 20 | 0 | 10 | |
| GSE43470 | NSMCE2 | 286053 | 22 | 0 | 21 | |
| GSE46452 | NSMCE2 | 286053 | 28 | 0 | 31 | |
| GSE47630 | NSMCE2 | 286053 | 24 | 0 | 16 | |
| GSE54993 | NSMCE2 | 286053 | 0 | 21 | 49 | |
| GSE54994 | NSMCE2 | 286053 | 37 | 1 | 15 | |
| GSE60625 | NSMCE2 | 286053 | 0 | 4 | 7 | |
| GSE74703 | NSMCE2 | 286053 | 19 | 0 | 17 | |
| GSE74704 | NSMCE2 | 286053 | 13 | 0 | 7 | |
| TCGA | NSMCE2 | 286053 | 69 | 1 | 26 |
Total number of gains: 252; Total number of losses: 27; Total Number of normals: 209.
Somatic mutations of NSMCE2:
Generating mutation plots.
Highly correlated genes for NSMCE2:
Showing top 20/1077 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NSMCE2 | ZSCAN21 | 0.78873 | 3 | 0 | 3 |
| NSMCE2 | PLCG1 | 0.782523 | 3 | 0 | 3 |
| NSMCE2 | GTPBP6 | 0.762026 | 3 | 0 | 3 |
| NSMCE2 | CEP192 | 0.75914 | 3 | 0 | 3 |
| NSMCE2 | CHD1 | 0.754675 | 3 | 0 | 3 |
| NSMCE2 | GLS | 0.751118 | 3 | 0 | 3 |
| NSMCE2 | TATDN1 | 0.748714 | 9 | 0 | 9 |
| NSMCE2 | RLIM | 0.747719 | 3 | 0 | 3 |
| NSMCE2 | ASXL2 | 0.746572 | 3 | 0 | 3 |
| NSMCE2 | ZBTB8A | 0.742161 | 3 | 0 | 3 |
| NSMCE2 | TMCO6 | 0.742142 | 3 | 0 | 3 |
| NSMCE2 | DHX38 | 0.738471 | 4 | 0 | 4 |
| NSMCE2 | TCF7L2 | 0.736523 | 3 | 0 | 3 |
| NSMCE2 | WDYHV1 | 0.730796 | 8 | 0 | 7 |
| NSMCE2 | DMTF1 | 0.727566 | 3 | 0 | 3 |
| NSMCE2 | EFCAB7 | 0.72314 | 4 | 0 | 4 |
| NSMCE2 | PELI2 | 0.721962 | 3 | 0 | 3 |
| NSMCE2 | RPP38 | 0.720406 | 3 | 0 | 3 |
| NSMCE2 | RAB34 | 0.7183 | 3 | 0 | 3 |
| NSMCE2 | NFS1 | 0.716817 | 4 | 0 | 4 |
For details and further investigation, click here
