| Full name: defensin beta 128 | Alias Symbol: DEFB-28 | ||
| Type: protein-coding gene | Cytoband: 20p13 | ||
| Entrez ID: 245939 | HGNC ID: HGNC:18106 | Ensembl Gene: ENSG00000185982 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of DEFB128:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | DEFB128 | 245939 | 25164 | 0.2906 | 0.0067 | |
| GSE53624 | DEFB128 | 245939 | 25164 | 0.2216 | 0.0633 | |
| GSE97050 | DEFB128 | 245939 | A_33_P3272962 | 0.1073 | 0.7229 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DEFB128 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of DEFB128:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DEFB128 | 245939 | 12 | 4 | 14 | |
| GSE20123 | DEFB128 | 245939 | 13 | 4 | 13 | |
| GSE43470 | DEFB128 | 245939 | 11 | 1 | 31 | |
| GSE46452 | DEFB128 | 245939 | 26 | 1 | 32 | |
| GSE47630 | DEFB128 | 245939 | 19 | 4 | 17 | |
| GSE54993 | DEFB128 | 245939 | 2 | 15 | 53 | |
| GSE54994 | DEFB128 | 245939 | 24 | 2 | 27 | |
| GSE60625 | DEFB128 | 245939 | 0 | 0 | 11 | |
| GSE74703 | DEFB128 | 245939 | 10 | 1 | 25 | |
| GSE74704 | DEFB128 | 245939 | 8 | 2 | 10 | |
| TCGA | DEFB128 | 245939 | 41 | 11 | 44 |
Total number of gains: 166; Total number of losses: 45; Total Number of normals: 277.
Somatic mutations of DEFB128:
Generating mutation plots.
Highly correlated genes for DEFB128:
Showing top 20/316 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DEFB128 | SERPINA10 | 0.839668 | 3 | 0 | 3 |
| DEFB128 | DEFB121 | 0.826932 | 3 | 0 | 3 |
| DEFB128 | KCNH3 | 0.824405 | 3 | 0 | 3 |
| DEFB128 | STRC | 0.81247 | 3 | 0 | 3 |
| DEFB128 | ATP2A1 | 0.81156 | 3 | 0 | 3 |
| DEFB128 | OR4D6 | 0.805582 | 3 | 0 | 3 |
| DEFB128 | SLC22A11 | 0.803499 | 3 | 0 | 3 |
| DEFB128 | BAALC | 0.800502 | 3 | 0 | 3 |
| DEFB128 | CLTCL1 | 0.797583 | 3 | 0 | 3 |
| DEFB128 | CNOT3 | 0.79235 | 3 | 0 | 3 |
| DEFB128 | FOXE3 | 0.791854 | 3 | 0 | 3 |
| DEFB128 | SUN5 | 0.788555 | 3 | 0 | 3 |
| DEFB128 | OR2H1 | 0.783512 | 3 | 0 | 3 |
| DEFB128 | TRIM10 | 0.781547 | 3 | 0 | 3 |
| DEFB128 | SLC26A1 | 0.77886 | 3 | 0 | 3 |
| DEFB128 | TNNI1 | 0.778499 | 3 | 0 | 3 |
| DEFB128 | C9orf153 | 0.777416 | 3 | 0 | 3 |
| DEFB128 | ZNF527 | 0.776931 | 3 | 0 | 3 |
| DEFB128 | ANKDD1A | 0.775416 | 3 | 0 | 3 |
| DEFB128 | F2RL3 | 0.774059 | 3 | 0 | 3 |
For details and further investigation, click here
