| Full name: tryptophan hydroxylase 2 | Alias Symbol: NTPH|FLJ37295 | ||
| Type: protein-coding gene | Cytoband: 12q21.1 | ||
| Entrez ID: 121278 | HGNC ID: HGNC:20692 | Ensembl Gene: ENSG00000139287 | OMIM ID: 607478 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TPH2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TPH2 | 121278 | 1555332_at | 0.0244 | 0.9379 | |
| GSE26886 | TPH2 | 121278 | 1555332_at | -0.0961 | 0.2679 | |
| GSE45670 | TPH2 | 121278 | 1555332_at | 0.0774 | 0.3652 | |
| GSE53622 | TPH2 | 121278 | 42311 | 0.5632 | 0.0000 | |
| GSE53624 | TPH2 | 121278 | 42311 | 0.5174 | 0.0037 | |
| GSE63941 | TPH2 | 121278 | 1555332_at | -0.0086 | 0.9522 | |
| GSE77861 | TPH2 | 121278 | 1555332_at | -0.0419 | 0.6189 | |
| GSE97050 | TPH2 | 121278 | A_24_P401787 | -0.1946 | 0.6162 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TPH2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TPH2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TPH2 | 121278 | 4 | 3 | 23 | |
| GSE20123 | TPH2 | 121278 | 4 | 3 | 23 | |
| GSE43470 | TPH2 | 121278 | 3 | 0 | 40 | |
| GSE46452 | TPH2 | 121278 | 8 | 1 | 50 | |
| GSE47630 | TPH2 | 121278 | 10 | 1 | 29 | |
| GSE54993 | TPH2 | 121278 | 0 | 5 | 65 | |
| GSE54994 | TPH2 | 121278 | 6 | 2 | 45 | |
| GSE60625 | TPH2 | 121278 | 0 | 0 | 11 | |
| GSE74703 | TPH2 | 121278 | 3 | 0 | 33 | |
| GSE74704 | TPH2 | 121278 | 3 | 2 | 15 | |
| TCGA | TPH2 | 121278 | 20 | 9 | 67 |
Total number of gains: 61; Total number of losses: 26; Total Number of normals: 401.
Somatic mutations of TPH2:
Generating mutation plots.
Highly correlated genes for TPH2:
Showing top 20/332 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TPH2 | RAB44 | 0.919051 | 3 | 0 | 3 |
| TPH2 | KCNK9 | 0.796845 | 3 | 0 | 3 |
| TPH2 | ATP2A1 | 0.754629 | 3 | 0 | 3 |
| TPH2 | OR2T27 | 0.754106 | 3 | 0 | 3 |
| TPH2 | KRTAP2-1 | 0.753333 | 4 | 0 | 4 |
| TPH2 | GPR173 | 0.742952 | 3 | 0 | 3 |
| TPH2 | WDR87 | 0.739011 | 3 | 0 | 3 |
| TPH2 | KRTAP10-12 | 0.738175 | 3 | 0 | 3 |
| TPH2 | TRIM46 | 0.735968 | 3 | 0 | 3 |
| TPH2 | GHSR | 0.731476 | 3 | 0 | 3 |
| TPH2 | PLA2G2C | 0.728625 | 3 | 0 | 3 |
| TPH2 | GCM2 | 0.725112 | 3 | 0 | 3 |
| TPH2 | BAALC | 0.723576 | 3 | 0 | 3 |
| TPH2 | OR2T1 | 0.722657 | 3 | 0 | 3 |
| TPH2 | OR2A5 | 0.722073 | 3 | 0 | 3 |
| TPH2 | EXOG | 0.719743 | 3 | 0 | 3 |
| TPH2 | DCDC1 | 0.716903 | 3 | 0 | 3 |
| TPH2 | ESR1 | 0.7163 | 4 | 0 | 4 |
| TPH2 | ACR | 0.713539 | 3 | 0 | 3 |
| TPH2 | BBC3 | 0.713507 | 3 | 0 | 3 |
For details and further investigation, click here
