| Full name: BR serine/threonine kinase 2 | Alias Symbol: PEN11B | ||
| Type: protein-coding gene | Cytoband: 11p15.5 | ||
| Entrez ID: 9024 | HGNC ID: HGNC:11405 | Ensembl Gene: ENSG00000174672 | OMIM ID: 609236 |
| Drug and gene relationship at DGIdb | |||
Expression of BRSK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BRSK2 | 9024 | 223715_at | -0.1689 | 0.5719 | |
| GSE20347 | BRSK2 | 9024 | 215010_s_at | -0.0414 | 0.5278 | |
| GSE23400 | BRSK2 | 9024 | 215010_s_at | -0.1114 | 0.0002 | |
| GSE26886 | BRSK2 | 9024 | 223715_at | -0.0594 | 0.6456 | |
| GSE29001 | BRSK2 | 9024 | 215010_s_at | -0.0637 | 0.5851 | |
| GSE38129 | BRSK2 | 9024 | 215010_s_at | -0.0408 | 0.4258 | |
| GSE45670 | BRSK2 | 9024 | 223715_at | 0.0441 | 0.5415 | |
| GSE53622 | BRSK2 | 9024 | 43392 | -0.4254 | 0.0155 | |
| GSE53624 | BRSK2 | 9024 | 61382 | 0.1718 | 0.0078 | |
| GSE63941 | BRSK2 | 9024 | 223715_at | 0.3551 | 0.1447 | |
| GSE77861 | BRSK2 | 9024 | 223715_at | -0.1628 | 0.0815 | |
| GSE97050 | BRSK2 | 9024 | A_24_P326708 | -0.3430 | 0.3476 | |
| SRP133303 | BRSK2 | 9024 | RNAseq | -0.9956 | 0.0048 | |
| SRP159526 | BRSK2 | 9024 | RNAseq | 0.5852 | 0.3553 | |
| SRP219564 | BRSK2 | 9024 | RNAseq | 1.8841 | 0.0836 | |
| TCGA | BRSK2 | 9024 | RNAseq | -1.2284 | 0.0008 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by BRSK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BRSK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BRSK2 | 9024 | 1 | 11 | 18 | |
| GSE20123 | BRSK2 | 9024 | 1 | 12 | 17 | |
| GSE43470 | BRSK2 | 9024 | 1 | 10 | 32 | |
| GSE46452 | BRSK2 | 9024 | 7 | 8 | 44 | |
| GSE47630 | BRSK2 | 9024 | 4 | 12 | 24 | |
| GSE54993 | BRSK2 | 9024 | 3 | 1 | 66 | |
| GSE54994 | BRSK2 | 9024 | 1 | 12 | 40 | |
| GSE60625 | BRSK2 | 9024 | 0 | 0 | 11 | |
| GSE74703 | BRSK2 | 9024 | 1 | 8 | 27 | |
| GSE74704 | BRSK2 | 9024 | 0 | 8 | 12 | |
| TCGA | BRSK2 | 9024 | 8 | 39 | 49 |
Total number of gains: 27; Total number of losses: 121; Total Number of normals: 340.
Somatic mutations of BRSK2:
Generating mutation plots.
Highly correlated genes for BRSK2:
Showing top 20/300 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BRSK2 | LINC01056 | 0.707141 | 3 | 0 | 3 |
| BRSK2 | TTLL6 | 0.701592 | 3 | 0 | 3 |
| BRSK2 | PDHA2 | 0.677177 | 3 | 0 | 3 |
| BRSK2 | LINC01210 | 0.670068 | 4 | 0 | 4 |
| BRSK2 | LINC01343 | 0.669586 | 3 | 0 | 3 |
| BRSK2 | LELP1 | 0.662932 | 3 | 0 | 3 |
| BRSK2 | TMEM59L | 0.653056 | 5 | 0 | 4 |
| BRSK2 | CALCA | 0.652069 | 5 | 0 | 4 |
| BRSK2 | IRGC | 0.651468 | 3 | 0 | 3 |
| BRSK2 | KCNH1 | 0.637967 | 4 | 0 | 4 |
| BRSK2 | C10orf90 | 0.63676 | 4 | 0 | 4 |
| BRSK2 | SSUH2 | 0.634579 | 4 | 0 | 4 |
| BRSK2 | HHIP | 0.632609 | 3 | 0 | 3 |
| BRSK2 | DEFB118 | 0.629767 | 5 | 0 | 5 |
| BRSK2 | GRPR | 0.626139 | 6 | 0 | 5 |
| BRSK2 | LINC00632 | 0.625351 | 4 | 0 | 3 |
| BRSK2 | SPATA32 | 0.617268 | 5 | 0 | 4 |
| BRSK2 | CPA1 | 0.616261 | 3 | 0 | 3 |
| BRSK2 | C21orf62 | 0.614513 | 4 | 0 | 3 |
| BRSK2 | KIR2DS1 | 0.614392 | 5 | 0 | 4 |
For details and further investigation, click here
