| Full name: defensin beta 118 | Alias Symbol: dJ1018D12.3|DEFB-18|ESC42 | ||
| Type: protein-coding gene | Cytoband: 20q11.21 | ||
| Entrez ID: 117285 | HGNC ID: HGNC:16196 | Ensembl Gene: ENSG00000131068 | OMIM ID: 607650 |
| Drug and gene relationship at DGIdb | |||
Expression of DEFB118:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DEFB118 | 117285 | 233221_at | -0.1784 | 0.4608 | |
| GSE26886 | DEFB118 | 117285 | 233221_at | -0.2795 | 0.0591 | |
| GSE45670 | DEFB118 | 117285 | 233221_at | 0.1125 | 0.2555 | |
| GSE53622 | DEFB118 | 117285 | 136643 | -0.0564 | 0.5823 | |
| GSE53624 | DEFB118 | 117285 | 136643 | -0.0489 | 0.6354 | |
| GSE63941 | DEFB118 | 117285 | 233221_at | 0.3810 | 0.0310 | |
| GSE77861 | DEFB118 | 117285 | 233221_at | -0.3152 | 0.0353 | |
| TCGA | DEFB118 | 117285 | RNAseq | 1.1861 | 0.6492 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DEFB118 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DEFB118:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DEFB118 | 117285 | 14 | 0 | 16 | |
| GSE20123 | DEFB118 | 117285 | 14 | 0 | 16 | |
| GSE43470 | DEFB118 | 117285 | 11 | 0 | 32 | |
| GSE46452 | DEFB118 | 117285 | 29 | 0 | 30 | |
| GSE47630 | DEFB118 | 117285 | 24 | 0 | 16 | |
| GSE54993 | DEFB118 | 117285 | 0 | 17 | 53 | |
| GSE54994 | DEFB118 | 117285 | 27 | 1 | 25 | |
| GSE60625 | DEFB118 | 117285 | 0 | 0 | 11 | |
| GSE74703 | DEFB118 | 117285 | 10 | 0 | 26 | |
| GSE74704 | DEFB118 | 117285 | 9 | 0 | 11 | |
| TCGA | DEFB118 | 117285 | 49 | 1 | 46 |
Total number of gains: 187; Total number of losses: 19; Total Number of normals: 282.
Somatic mutations of DEFB118:
Generating mutation plots.
Highly correlated genes for DEFB118:
Showing top 20/278 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DEFB118 | DMWD | 0.725906 | 3 | 0 | 3 |
| DEFB118 | PRB1 | 0.712041 | 5 | 0 | 5 |
| DEFB118 | NLRP12 | 0.709134 | 4 | 0 | 4 |
| DEFB118 | TNFRSF13C | 0.690075 | 4 | 0 | 4 |
| DEFB118 | C2CD2L | 0.688923 | 3 | 0 | 3 |
| DEFB118 | SOX10 | 0.67489 | 5 | 0 | 5 |
| DEFB118 | MADCAM1 | 0.673964 | 4 | 0 | 4 |
| DEFB118 | C2orf16 | 0.67134 | 4 | 0 | 3 |
| DEFB118 | ZNF169 | 0.667239 | 3 | 0 | 3 |
| DEFB118 | UBL4B | 0.660264 | 3 | 0 | 3 |
| DEFB118 | HOXA2 | 0.659134 | 3 | 0 | 3 |
| DEFB118 | TCL6 | 0.656601 | 5 | 0 | 5 |
| DEFB118 | SPATA32 | 0.65653 | 5 | 0 | 5 |
| DEFB118 | FAM135B | 0.655134 | 4 | 0 | 4 |
| DEFB118 | CD300LB | 0.654826 | 4 | 0 | 4 |
| DEFB118 | PKNOX2 | 0.651377 | 3 | 0 | 3 |
| DEFB118 | SCAMP5 | 0.650697 | 4 | 0 | 4 |
| DEFB118 | VIPR1 | 0.650311 | 3 | 0 | 3 |
| DEFB118 | MAPK12 | 0.649859 | 4 | 0 | 3 |
| DEFB118 | OOSP2 | 0.648567 | 3 | 0 | 3 |
For details and further investigation, click here
