| Full name: carboxypeptidase A1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 7q32.2 | ||
| Entrez ID: 1357 | HGNC ID: HGNC:2296 | Ensembl Gene: ENSG00000091704 | OMIM ID: 114850 |
| Drug and gene relationship at DGIdb | |||
Expression of CPA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CPA1 | 1357 | 205615_at | -0.2130 | 0.2936 | |
| GSE20347 | CPA1 | 1357 | 205615_at | -0.0522 | 0.3314 | |
| GSE23400 | CPA1 | 1357 | 205615_at | -0.1282 | 0.0000 | |
| GSE26886 | CPA1 | 1357 | 205615_at | 0.1329 | 0.0770 | |
| GSE29001 | CPA1 | 1357 | 205615_at | -0.1004 | 0.2426 | |
| GSE38129 | CPA1 | 1357 | 205615_at | -0.0629 | 0.2718 | |
| GSE45670 | CPA1 | 1357 | 205615_at | -0.0337 | 0.6589 | |
| GSE53622 | CPA1 | 1357 | 43921 | 0.3003 | 0.0028 | |
| GSE53624 | CPA1 | 1357 | 43921 | -0.0214 | 0.9076 | |
| GSE63941 | CPA1 | 1357 | 205615_at | -0.0600 | 0.6869 | |
| GSE77861 | CPA1 | 1357 | 205615_at | -0.1729 | 0.1551 | |
| TCGA | CPA1 | 1357 | RNAseq | -0.3637 | 0.8288 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CPA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CPA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CPA1 | 1357 | 8 | 1 | 21 | |
| GSE20123 | CPA1 | 1357 | 8 | 1 | 21 | |
| GSE43470 | CPA1 | 1357 | 2 | 3 | 38 | |
| GSE46452 | CPA1 | 1357 | 7 | 2 | 50 | |
| GSE47630 | CPA1 | 1357 | 7 | 4 | 29 | |
| GSE54993 | CPA1 | 1357 | 3 | 5 | 62 | |
| GSE54994 | CPA1 | 1357 | 7 | 7 | 39 | |
| GSE60625 | CPA1 | 1357 | 0 | 0 | 11 | |
| GSE74703 | CPA1 | 1357 | 2 | 3 | 31 | |
| GSE74704 | CPA1 | 1357 | 4 | 1 | 15 | |
| TCGA | CPA1 | 1357 | 28 | 21 | 47 |
Total number of gains: 76; Total number of losses: 48; Total Number of normals: 364.
Somatic mutations of CPA1:
Generating mutation plots.
Highly correlated genes for CPA1:
Showing top 20/276 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CPA1 | HCG9 | 0.695109 | 3 | 0 | 3 |
| CPA1 | COLQ | 0.688924 | 3 | 0 | 3 |
| CPA1 | PPP3CC | 0.687007 | 3 | 0 | 3 |
| CPA1 | HRC | 0.683406 | 3 | 0 | 3 |
| CPA1 | THRB | 0.673557 | 4 | 0 | 4 |
| CPA1 | RIMS1 | 0.672871 | 4 | 0 | 4 |
| CPA1 | MOBP | 0.671986 | 3 | 0 | 3 |
| CPA1 | TAAR5 | 0.671208 | 3 | 0 | 3 |
| CPA1 | SIRT3 | 0.664706 | 3 | 0 | 3 |
| CPA1 | CPN1 | 0.658632 | 3 | 0 | 3 |
| CPA1 | HAAO | 0.650054 | 5 | 0 | 4 |
| CPA1 | STXBP6 | 0.647644 | 3 | 0 | 3 |
| CPA1 | ABCC8 | 0.641546 | 4 | 0 | 3 |
| CPA1 | GYPC | 0.641047 | 3 | 0 | 3 |
| CPA1 | TMPRSS6 | 0.64051 | 4 | 0 | 4 |
| CPA1 | FGF4 | 0.638803 | 3 | 0 | 3 |
| CPA1 | FGA | 0.63545 | 3 | 0 | 3 |
| CPA1 | MASP1 | 0.633184 | 4 | 0 | 4 |
| CPA1 | NDST2 | 0.633136 | 3 | 0 | 3 |
| CPA1 | DCLK2 | 0.630101 | 4 | 0 | 3 |
For details and further investigation, click here
