| Full name: potassium voltage-gated channel subfamily H member 1 | Alias Symbol: Kv10.1|eag|h-eag|eag1 | ||
| Type: protein-coding gene | Cytoband: 1q32.2 | ||
| Entrez ID: 3756 | HGNC ID: HGNC:6250 | Ensembl Gene: ENSG00000143473 | OMIM ID: 603305 |
| Drug and gene relationship at DGIdb | |||
Expression of KCNH1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KCNH1 | 3756 | 207635_s_at | -0.0517 | 0.7704 | |
| GSE20347 | KCNH1 | 3756 | 207635_s_at | 0.0228 | 0.7283 | |
| GSE23400 | KCNH1 | 3756 | 207635_s_at | -0.0912 | 0.0011 | |
| GSE26886 | KCNH1 | 3756 | 207635_s_at | 0.1905 | 0.0877 | |
| GSE29001 | KCNH1 | 3756 | 207635_s_at | -0.1307 | 0.1107 | |
| GSE38129 | KCNH1 | 3756 | 207635_s_at | -0.1221 | 0.0253 | |
| GSE45670 | KCNH1 | 3756 | 207635_s_at | -0.0507 | 0.5259 | |
| GSE53622 | KCNH1 | 3756 | 33859 | 0.8859 | 0.0022 | |
| GSE53624 | KCNH1 | 3756 | 33859 | 0.8032 | 0.0005 | |
| GSE63941 | KCNH1 | 3756 | 207635_s_at | -0.1352 | 0.3112 | |
| GSE77861 | KCNH1 | 3756 | 207635_s_at | -0.1552 | 0.1436 | |
| GSE97050 | KCNH1 | 3756 | A_23_P74943 | 0.0046 | 0.9965 | |
| SRP133303 | KCNH1 | 3756 | RNAseq | 0.2293 | 0.6362 | |
| SRP159526 | KCNH1 | 3756 | RNAseq | 2.4954 | 0.0019 | |
| TCGA | KCNH1 | 3756 | RNAseq | 0.2087 | 0.6306 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by KCNH1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KCNH1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KCNH1 | 3756 | 10 | 0 | 20 | |
| GSE20123 | KCNH1 | 3756 | 10 | 0 | 20 | |
| GSE43470 | KCNH1 | 3756 | 7 | 0 | 36 | |
| GSE46452 | KCNH1 | 3756 | 3 | 1 | 55 | |
| GSE47630 | KCNH1 | 3756 | 15 | 0 | 25 | |
| GSE54993 | KCNH1 | 3756 | 0 | 6 | 64 | |
| GSE54994 | KCNH1 | 3756 | 13 | 1 | 39 | |
| GSE60625 | KCNH1 | 3756 | 0 | 0 | 11 | |
| GSE74703 | KCNH1 | 3756 | 7 | 0 | 29 | |
| GSE74704 | KCNH1 | 3756 | 4 | 0 | 16 | |
| TCGA | KCNH1 | 3756 | 44 | 4 | 48 |
Total number of gains: 113; Total number of losses: 12; Total Number of normals: 363.
Somatic mutations of KCNH1:
Generating mutation plots.
Highly correlated genes for KCNH1:
Showing top 20/174 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KCNH1 | KIRREL3-AS2 | 0.652284 | 3 | 0 | 3 |
| KCNH1 | BRSK2 | 0.637967 | 4 | 0 | 4 |
| KCNH1 | ANKRD33 | 0.630133 | 3 | 0 | 3 |
| KCNH1 | ACKR2 | 0.619564 | 3 | 0 | 3 |
| KCNH1 | DBNDD1 | 0.611418 | 3 | 0 | 3 |
| KCNH1 | BHLHE23 | 0.601148 | 3 | 0 | 3 |
| KCNH1 | PSG1 | 0.598001 | 3 | 0 | 3 |
| KCNH1 | CRYAA | 0.594873 | 4 | 0 | 4 |
| KCNH1 | CPA5 | 0.592334 | 3 | 0 | 3 |
| KCNH1 | ABO | 0.591948 | 3 | 0 | 3 |
| KCNH1 | C16orf82 | 0.583039 | 4 | 0 | 3 |
| KCNH1 | CSHL1 | 0.581688 | 6 | 0 | 4 |
| KCNH1 | KCNE1 | 0.578602 | 4 | 0 | 3 |
| KCNH1 | UCP1 | 0.575149 | 6 | 0 | 5 |
| KCNH1 | FUT9 | 0.573455 | 3 | 0 | 3 |
| KCNH1 | COX6A2 | 0.572983 | 6 | 0 | 4 |
| KCNH1 | SPRY3 | 0.572684 | 4 | 0 | 4 |
| KCNH1 | MYO1A | 0.571959 | 6 | 0 | 4 |
| KCNH1 | PPM1N | 0.57149 | 3 | 0 | 3 |
| KCNH1 | SHCBP1L | 0.570572 | 4 | 0 | 4 |
For details and further investigation, click here
