| Full name: hedgehog interacting protein | Alias Symbol: HIP|FLJ20992 | ||
| Type: protein-coding gene | Cytoband: 4q31.21 | ||
| Entrez ID: 64399 | HGNC ID: HGNC:14866 | Ensembl Gene: ENSG00000164161 | OMIM ID: 606178 |
| Drug and gene relationship at DGIdb | |||
HHIP involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway | |
| hsa04340 | Hedgehog signaling pathway | |
| hsa05200 | Pathways in cancer | |
| hsa05217 | Basal cell carcinoma |
Expression of HHIP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HHIP | 64399 | 230135_at | 0.0056 | 0.9905 | |
| GSE26886 | HHIP | 64399 | 237466_s_at | -0.2212 | 0.3057 | |
| GSE45670 | HHIP | 64399 | 237466_s_at | -0.0191 | 0.9406 | |
| GSE53622 | HHIP | 64399 | 43486 | 0.6944 | 0.0050 | |
| GSE53624 | HHIP | 64399 | 43486 | 0.7284 | 0.0000 | |
| GSE63941 | HHIP | 64399 | 237466_s_at | 0.1739 | 0.2269 | |
| GSE77861 | HHIP | 64399 | 237466_s_at | -0.6302 | 0.0163 | |
| GSE97050 | HHIP | 64399 | A_23_P167129 | -0.0475 | 0.8831 | |
| SRP133303 | HHIP | 64399 | RNAseq | 1.0764 | 0.0000 | |
| SRP193095 | HHIP | 64399 | RNAseq | -0.7275 | 0.1037 | |
| SRP219564 | HHIP | 64399 | RNAseq | 0.9314 | 0.0569 | |
| TCGA | HHIP | 64399 | RNAseq | -1.8516 | 0.0025 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by HHIP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HHIP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HHIP | 64399 | 0 | 12 | 18 | |
| GSE20123 | HHIP | 64399 | 0 | 12 | 18 | |
| GSE43470 | HHIP | 64399 | 0 | 13 | 30 | |
| GSE46452 | HHIP | 64399 | 1 | 36 | 22 | |
| GSE47630 | HHIP | 64399 | 0 | 22 | 18 | |
| GSE54993 | HHIP | 64399 | 10 | 0 | 60 | |
| GSE54994 | HHIP | 64399 | 2 | 11 | 40 | |
| GSE60625 | HHIP | 64399 | 0 | 1 | 10 | |
| GSE74703 | HHIP | 64399 | 0 | 11 | 25 | |
| GSE74704 | HHIP | 64399 | 0 | 6 | 14 | |
| TCGA | HHIP | 64399 | 12 | 32 | 52 |
Total number of gains: 25; Total number of losses: 156; Total Number of normals: 307.
Somatic mutations of HHIP:
Generating mutation plots.
Highly correlated genes for HHIP:
Showing top 20/122 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HHIP | UROC1 | 0.75449 | 4 | 0 | 3 |
| HHIP | ADIG | 0.725713 | 3 | 0 | 3 |
| HHIP | TSKS | 0.719173 | 3 | 0 | 3 |
| HHIP | SLC12A3 | 0.714383 | 3 | 0 | 3 |
| HHIP | CA4 | 0.704833 | 4 | 0 | 4 |
| HHIP | DDC | 0.704228 | 3 | 0 | 3 |
| HHIP | KCNA6 | 0.702575 | 3 | 0 | 3 |
| HHIP | CCL27 | 0.694683 | 4 | 0 | 3 |
| HHIP | GZMM | 0.691746 | 3 | 0 | 3 |
| HHIP | DPEP3 | 0.690276 | 4 | 0 | 4 |
| HHIP | COX4I2 | 0.685084 | 3 | 0 | 3 |
| HHIP | TEX13B | 0.684751 | 3 | 0 | 3 |
| HHIP | ITIH3 | 0.680557 | 3 | 0 | 3 |
| HHIP | BSND | 0.679027 | 4 | 0 | 3 |
| HHIP | PROCA1 | 0.679014 | 4 | 0 | 4 |
| HHIP | TUBA8 | 0.678354 | 3 | 0 | 3 |
| HHIP | NACAD | 0.677283 | 3 | 0 | 3 |
| HHIP | NPPB | 0.674612 | 4 | 0 | 3 |
| HHIP | CELA3B | 0.672745 | 3 | 0 | 3 |
| HHIP | NXNL1 | 0.665666 | 4 | 0 | 4 |
For details and further investigation, click here
