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Severity: Warning

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Filename: controllers/Result_pages.php

Line Number: 123

Backtrace:

File: /data/webapp/var/www/html/ESCCdb/application/controllers/Result_pages.php
Line: 123
Function: exec

File: /data/webapp/var/www/html/ESCCdb/application/controllers/Result_pages.php
Line: 387
Function: drawSurvPlot

File: /data/webapp/var/www/html/ESCCdb/index.php
Line: 315
Function: require_once

Multi-Omics Database of ESCC

 

CACTIN

 

Full name: cactin, spliceosome C complex subunit Alias Symbol: NY-REN-24|fSAPc|cactin
Type: protein-coding gene Cytoband: 19p13.3
Entrez ID: 58509 HGNC ID: HGNC:29938 Ensembl Gene: ENSG00000105298 OMIM ID: 
Drug and gene relationship at DGIdb

 

Expression of CACTIN:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CACTIN 58509 214892_x_at 0.3015 0.1747
GSE20347 CACTIN 58509 214892_x_at 0.2617 0.0029
GSE23400 CACTIN 58509 214892_x_at 0.0861 0.0213
GSE26886 CACTIN 58509 214892_x_at 0.5540 0.0000
GSE29001 CACTIN 58509 214892_x_at 0.0366 0.8736
GSE38129 CACTIN 58509 214892_x_at 0.1437 0.1077
GSE45670 CACTIN 58509 214892_x_at 0.2258 0.0072
GSE53622 CACTIN 58509 55215 0.4406 0.0000
GSE53624 CACTIN 58509 141946 0.5563 0.0000
GSE63941 CACTIN 58509 214892_x_at 0.6428 0.0027
GSE77861 CACTIN 58509 214892_x_at 0.4292 0.0090
SRP007169 CACTIN 58509 RNAseq 1.5987 0.0162
SRP064894 CACTIN 58509 RNAseq 0.5104 0.0056
SRP133303 CACTIN 58509 RNAseq 0.3339 0.0760
SRP159526 CACTIN 58509 RNAseq 0.3370 0.1612
SRP193095 CACTIN 58509 RNAseq 0.4839 0.0000
SRP219564 CACTIN 58509 RNAseq 0.1357 0.5848

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by CACTIN expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  

Copy number change of CACTIN:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CACTIN 58509 5 3 22
GSE20123 CACTIN 58509 4 2 24
GSE43470 CACTIN 58509 1 9 33
GSE46452 CACTIN 58509 47 1 11
GSE47630 CACTIN 58509 5 7 28
GSE54993 CACTIN 58509 16 3 51
GSE54994 CACTIN 58509 8 16 29
GSE60625 CACTIN 58509 9 0 2
GSE74703 CACTIN 58509 1 6 29
GSE74704 CACTIN 58509 1 2 17
TCGA CACTIN 58509 10 19 67

Total number of gains: 107; Total number of losses: 68; Total Number of normals: 313.  

 

Somatic mutations of CACTIN:

 

Generating mutation plots.

 

Highly correlated genes for CACTIN:

 

Showing top 20/1029 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CACTINSLC39A30.766879303
CACTINRILPL10.742652303
CACTINMYO9B0.726932606
CACTINANKRD520.726366404
CACTINADAP10.721405404
CACTINFBRSL10.721056303
CACTINUCN20.713475303
CACTINDPP90.711546404
CACTINMAN2B10.711298303
CACTINHAUS70.70633303
CACTINGAS2L10.704238303
CACTINZMIZ20.703696404
CACTINNTPCR0.701744303
CACTINPOLD10.700599505
CACTINGLG10.700203404
CACTINCNOT30.699935403
CACTINPPP2R5D0.691283303
CACTINCEMP10.691132404
CACTINHSPBP10.688737606
CACTINKDM6B0.68615605

For details and further investigation, click here