| Full name: mannosidase alpha class 2B member 1 | Alias Symbol: LAMAN | ||
| Type: protein-coding gene | Cytoband: 19p13.13 | ||
| Entrez ID: 4125 | HGNC ID: HGNC:6826 | Ensembl Gene: ENSG00000104774 | OMIM ID: 609458 |
| Drug and gene relationship at DGIdb | |||
Expression of MAN2B1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAN2B1 | 4125 | 209166_s_at | 0.8900 | 0.1430 | |
| GSE20347 | MAN2B1 | 4125 | 209166_s_at | 0.1462 | 0.2015 | |
| GSE23400 | MAN2B1 | 4125 | 209166_s_at | 0.5632 | 0.0000 | |
| GSE26886 | MAN2B1 | 4125 | 209166_s_at | 0.9635 | 0.0000 | |
| GSE29001 | MAN2B1 | 4125 | 209166_s_at | 0.4274 | 0.0169 | |
| GSE38129 | MAN2B1 | 4125 | 209166_s_at | 0.2829 | 0.0071 | |
| GSE45670 | MAN2B1 | 4125 | 209166_s_at | 0.3539 | 0.0088 | |
| GSE53622 | MAN2B1 | 4125 | 11981 | 0.2955 | 0.0002 | |
| GSE53624 | MAN2B1 | 4125 | 11981 | 0.4868 | 0.0000 | |
| GSE63941 | MAN2B1 | 4125 | 209166_s_at | -0.7889 | 0.0673 | |
| GSE77861 | MAN2B1 | 4125 | 209166_s_at | 0.3950 | 0.0081 | |
| GSE97050 | MAN2B1 | 4125 | A_24_P370156 | 0.5358 | 0.1772 | |
| SRP007169 | MAN2B1 | 4125 | RNAseq | 0.0711 | 0.8872 | |
| SRP008496 | MAN2B1 | 4125 | RNAseq | 0.2627 | 0.3746 | |
| SRP064894 | MAN2B1 | 4125 | RNAseq | 1.1532 | 0.0000 | |
| SRP133303 | MAN2B1 | 4125 | RNAseq | 0.4312 | 0.0077 | |
| SRP159526 | MAN2B1 | 4125 | RNAseq | 0.3876 | 0.2067 | |
| SRP193095 | MAN2B1 | 4125 | RNAseq | 0.2264 | 0.1500 | |
| SRP219564 | MAN2B1 | 4125 | RNAseq | 1.1476 | 0.0068 | |
| TCGA | MAN2B1 | 4125 | RNAseq | -0.0280 | 0.5524 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by MAN2B1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAN2B1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAN2B1 | 4125 | 4 | 2 | 24 | |
| GSE20123 | MAN2B1 | 4125 | 3 | 1 | 26 | |
| GSE43470 | MAN2B1 | 4125 | 2 | 6 | 35 | |
| GSE46452 | MAN2B1 | 4125 | 47 | 1 | 11 | |
| GSE47630 | MAN2B1 | 4125 | 4 | 7 | 29 | |
| GSE54993 | MAN2B1 | 4125 | 16 | 3 | 51 | |
| GSE54994 | MAN2B1 | 4125 | 6 | 13 | 34 | |
| GSE60625 | MAN2B1 | 4125 | 9 | 0 | 2 | |
| GSE74703 | MAN2B1 | 4125 | 2 | 4 | 30 | |
| GSE74704 | MAN2B1 | 4125 | 0 | 1 | 19 | |
| TCGA | MAN2B1 | 4125 | 16 | 13 | 67 |
Total number of gains: 109; Total number of losses: 51; Total Number of normals: 328.
Somatic mutations of MAN2B1:
Generating mutation plots.
Highly correlated genes for MAN2B1:
Showing top 20/1291 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAN2B1 | PCYT1A | 0.875198 | 3 | 0 | 3 |
| MAN2B1 | TBX1 | 0.827054 | 3 | 0 | 3 |
| MAN2B1 | LTBR | 0.81462 | 3 | 0 | 3 |
| MAN2B1 | TMEM63B | 0.808625 | 3 | 0 | 3 |
| MAN2B1 | PRR13 | 0.77499 | 3 | 0 | 3 |
| MAN2B1 | PREX1 | 0.7695 | 3 | 0 | 3 |
| MAN2B1 | RILPL1 | 0.751029 | 3 | 0 | 3 |
| MAN2B1 | MRPL36 | 0.749715 | 3 | 0 | 3 |
| MAN2B1 | DOCK6 | 0.744725 | 3 | 0 | 3 |
| MAN2B1 | ZNF496 | 0.744545 | 4 | 0 | 4 |
| MAN2B1 | OSR2 | 0.737781 | 4 | 0 | 3 |
| MAN2B1 | TMTC4 | 0.737521 | 4 | 0 | 3 |
| MAN2B1 | IRF2BP2 | 0.736636 | 3 | 0 | 3 |
| MAN2B1 | ZNF703 | 0.733651 | 3 | 0 | 3 |
| MAN2B1 | RHBDD2 | 0.730855 | 5 | 0 | 4 |
| MAN2B1 | CNPY3 | 0.71702 | 6 | 0 | 5 |
| MAN2B1 | ZCCHC3 | 0.715364 | 3 | 0 | 3 |
| MAN2B1 | MED12 | 0.712352 | 3 | 0 | 3 |
| MAN2B1 | CACTIN | 0.711298 | 3 | 0 | 3 |
| MAN2B1 | LRP6 | 0.710473 | 3 | 0 | 3 |
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