| Full name: lysine demethylase 6B | Alias Symbol: KIAA0346 | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 23135 | HGNC ID: HGNC:29012 | Ensembl Gene: ENSG00000132510 | OMIM ID: 611577 |
| Drug and gene relationship at DGIdb | |||
Expression of KDM6B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KDM6B | 23135 | 41386_i_at | 0.6739 | 0.1332 | |
| GSE20347 | KDM6B | 23135 | 41386_i_at | 0.1775 | 0.2232 | |
| GSE23400 | KDM6B | 23135 | 41386_i_at | -0.0147 | 0.8455 | |
| GSE26886 | KDM6B | 23135 | 41387_r_at | 0.6779 | 0.0000 | |
| GSE29001 | KDM6B | 23135 | 41387_r_at | 0.1398 | 0.6470 | |
| GSE38129 | KDM6B | 23135 | 41386_i_at | 0.0963 | 0.5060 | |
| GSE45670 | KDM6B | 23135 | 41387_r_at | -0.0618 | 0.6265 | |
| GSE63941 | KDM6B | 23135 | 41387_r_at | 0.5546 | 0.0574 | |
| GSE77861 | KDM6B | 23135 | 41387_r_at | 0.1829 | 0.2637 | |
| GSE97050 | KDM6B | 23135 | A_24_P942630 | 0.2568 | 0.4272 | |
| SRP007169 | KDM6B | 23135 | RNAseq | 2.0966 | 0.0000 | |
| SRP008496 | KDM6B | 23135 | RNAseq | 2.0964 | 0.0000 | |
| SRP064894 | KDM6B | 23135 | RNAseq | -0.0224 | 0.9463 | |
| SRP133303 | KDM6B | 23135 | RNAseq | 0.3244 | 0.0833 | |
| SRP159526 | KDM6B | 23135 | RNAseq | 0.2230 | 0.5621 | |
| SRP193095 | KDM6B | 23135 | RNAseq | 0.9271 | 0.0000 | |
| SRP219564 | KDM6B | 23135 | RNAseq | 0.3376 | 0.2168 | |
| TCGA | KDM6B | 23135 | RNAseq | -0.0353 | 0.4862 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by KDM6B expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of KDM6B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KDM6B | 23135 | 4 | 2 | 24 | |
| GSE20123 | KDM6B | 23135 | 4 | 3 | 23 | |
| GSE43470 | KDM6B | 23135 | 1 | 6 | 36 | |
| GSE46452 | KDM6B | 23135 | 34 | 1 | 24 | |
| GSE47630 | KDM6B | 23135 | 7 | 1 | 32 | |
| GSE54993 | KDM6B | 23135 | 4 | 3 | 63 | |
| GSE54994 | KDM6B | 23135 | 5 | 8 | 40 | |
| GSE60625 | KDM6B | 23135 | 4 | 0 | 7 | |
| GSE74703 | KDM6B | 23135 | 1 | 3 | 32 | |
| GSE74704 | KDM6B | 23135 | 2 | 1 | 17 | |
| TCGA | KDM6B | 23135 | 17 | 21 | 58 |
Total number of gains: 83; Total number of losses: 49; Total Number of normals: 356.
Somatic mutations of KDM6B:
Generating mutation plots.
Highly correlated genes for KDM6B:
Showing top 20/774 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KDM6B | KPNA1 | 0.820148 | 3 | 0 | 3 |
| KDM6B | FZR1 | 0.814486 | 3 | 0 | 3 |
| KDM6B | FAM167B | 0.803655 | 3 | 0 | 3 |
| KDM6B | HAUS7 | 0.79736 | 3 | 0 | 3 |
| KDM6B | WDR75 | 0.777593 | 3 | 0 | 3 |
| KDM6B | MYO7A | 0.772882 | 3 | 0 | 3 |
| KDM6B | MAST2 | 0.771358 | 3 | 0 | 3 |
| KDM6B | ULK1 | 0.769023 | 3 | 0 | 3 |
| KDM6B | ZNF358 | 0.76818 | 3 | 0 | 3 |
| KDM6B | MTRR | 0.766078 | 3 | 0 | 3 |
| KDM6B | TP53I13 | 0.765418 | 4 | 0 | 4 |
| KDM6B | CCDC150 | 0.764532 | 3 | 0 | 3 |
| KDM6B | IGF2R | 0.76246 | 3 | 0 | 3 |
| KDM6B | NUP43 | 0.761506 | 3 | 0 | 3 |
| KDM6B | ZNF417 | 0.759262 | 3 | 0 | 3 |
| KDM6B | TFRC | 0.758615 | 3 | 0 | 3 |
| KDM6B | RBM17 | 0.758495 | 3 | 0 | 3 |
| KDM6B | TGFBR1 | 0.758001 | 3 | 0 | 3 |
| KDM6B | NCAPG | 0.754518 | 3 | 0 | 3 |
| KDM6B | SLC39A3 | 0.751458 | 4 | 0 | 4 |
For details and further investigation, click here
