| Full name: CCR4-NOT transcription complex subunit 3 | Alias Symbol: NOT3H|KIAA0691|LENG2 | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 4849 | HGNC ID: HGNC:7879 | Ensembl Gene: ENSG00000088038 | OMIM ID: 604910 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CNOT3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CNOT3 | 4849 | 203239_s_at | 0.9117 | 0.0900 | |
| GSE20347 | CNOT3 | 4849 | 203239_s_at | 0.2350 | 0.1610 | |
| GSE23400 | CNOT3 | 4849 | 203239_s_at | 0.4612 | 0.0000 | |
| GSE26886 | CNOT3 | 4849 | 229143_at | 0.2955 | 0.3112 | |
| GSE29001 | CNOT3 | 4849 | 203239_s_at | 0.0215 | 0.8638 | |
| GSE38129 | CNOT3 | 4849 | 203239_s_at | 0.3819 | 0.0006 | |
| GSE45670 | CNOT3 | 4849 | 229143_at | -0.2285 | 0.1860 | |
| GSE53622 | CNOT3 | 4849 | 1584 | 0.1628 | 0.0408 | |
| GSE53624 | CNOT3 | 4849 | 1584 | 0.1253 | 0.1294 | |
| GSE63941 | CNOT3 | 4849 | 203239_s_at | 2.0787 | 0.0001 | |
| GSE77861 | CNOT3 | 4849 | 203239_s_at | 0.4609 | 0.0867 | |
| GSE97050 | CNOT3 | 4849 | A_33_P3271171 | 0.0062 | 0.9801 | |
| SRP007169 | CNOT3 | 4849 | RNAseq | 1.2756 | 0.0121 | |
| SRP008496 | CNOT3 | 4849 | RNAseq | 0.9570 | 0.0224 | |
| SRP064894 | CNOT3 | 4849 | RNAseq | 0.5036 | 0.0097 | |
| SRP133303 | CNOT3 | 4849 | RNAseq | 0.3999 | 0.0221 | |
| SRP159526 | CNOT3 | 4849 | RNAseq | 0.7226 | 0.0175 | |
| SRP193095 | CNOT3 | 4849 | RNAseq | 0.4690 | 0.0063 | |
| SRP219564 | CNOT3 | 4849 | RNAseq | -0.0248 | 0.8849 | |
| TCGA | CNOT3 | 4849 | RNAseq | 0.1232 | 0.0084 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by CNOT3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CNOT3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CNOT3 | 4849 | 3 | 4 | 23 | |
| GSE20123 | CNOT3 | 4849 | 3 | 3 | 24 | |
| GSE43470 | CNOT3 | 4849 | 2 | 11 | 30 | |
| GSE46452 | CNOT3 | 4849 | 45 | 1 | 13 | |
| GSE47630 | CNOT3 | 4849 | 8 | 6 | 26 | |
| GSE54993 | CNOT3 | 4849 | 17 | 4 | 49 | |
| GSE54994 | CNOT3 | 4849 | 4 | 14 | 35 | |
| GSE60625 | CNOT3 | 4849 | 9 | 0 | 2 | |
| GSE74703 | CNOT3 | 4849 | 2 | 7 | 27 | |
| GSE74704 | CNOT3 | 4849 | 3 | 1 | 16 | |
| TCGA | CNOT3 | 4849 | 19 | 15 | 62 |
Total number of gains: 115; Total number of losses: 66; Total Number of normals: 307.
Somatic mutations of CNOT3:
Generating mutation plots.
Highly correlated genes for CNOT3:
Showing top 20/373 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CNOT3 | STRC | 0.88719 | 3 | 0 | 3 |
| CNOT3 | DCDC1 | 0.86654 | 3 | 0 | 3 |
| CNOT3 | TMEM235 | 0.866224 | 3 | 0 | 3 |
| CNOT3 | C9orf153 | 0.864614 | 3 | 0 | 3 |
| CNOT3 | YY2 | 0.860969 | 3 | 0 | 3 |
| CNOT3 | MRGPRG | 0.849032 | 3 | 0 | 3 |
| CNOT3 | STK11 | 0.84857 | 3 | 0 | 3 |
| CNOT3 | SLC22A31 | 0.846632 | 3 | 0 | 3 |
| CNOT3 | TMEM105 | 0.838229 | 3 | 0 | 3 |
| CNOT3 | CHST10 | 0.836023 | 3 | 0 | 3 |
| CNOT3 | SPACA3 | 0.835604 | 3 | 0 | 3 |
| CNOT3 | SUN5 | 0.828337 | 3 | 0 | 3 |
| CNOT3 | F2RL3 | 0.828306 | 3 | 0 | 3 |
| CNOT3 | PLA2G2C | 0.818852 | 3 | 0 | 3 |
| CNOT3 | SHISA8 | 0.81792 | 3 | 0 | 3 |
| CNOT3 | LBX2 | 0.815768 | 3 | 0 | 3 |
| CNOT3 | C19orf71 | 0.811806 | 3 | 0 | 3 |
| CNOT3 | OR10AD1 | 0.80934 | 3 | 0 | 3 |
| CNOT3 | LHB | 0.808863 | 3 | 0 | 3 |
| CNOT3 | OR2T27 | 0.801898 | 3 | 0 | 3 |
For details and further investigation, click here
