POLD1

 

Full name: DNA polymerase delta 1, catalytic subunit Alias Symbol: CDC2
Type: protein-coding gene Cytoband: 19q13.3
Entrez ID: 5424 HGNC ID: HGNC:9175 Ensembl Gene: ENSG00000062822 OMIM ID: 174761
Drug and gene relationship at DGIdb

 

POLD1 involved pathways:

KEGG pathway Description View
hsa05166HTLV-I infection

 

Expression of POLD1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 POLD1 5424 203422_at 1.0379 0.0316
GSE20347 POLD1 5424 203422_at 0.4845 0.0055
GSE23400 POLD1 5424 203422_at 0.2200 0.0000
GSE26886 POLD1 5424 203422_at 0.8284 0.0000
GSE29001 POLD1 5424 203422_at 0.5065 0.0204
GSE38129 POLD1 5424 203422_at 0.6683 0.0000
GSE45670 POLD1 5424 203422_at 0.7312 0.0000
GSE53622 POLD1 5424 102967 -0.0742 0.2425
GSE53624 POLD1 5424 102967 0.2910 0.0000
GSE63941 POLD1 5424 203422_at 1.5791 0.0001
GSE77861 POLD1 5424 203422_at 0.3056 0.0400
GSE97050 POLD1 5424 A_23_P50455 0.0586 0.8415
SRP007169 POLD1 5424 RNAseq 1.6757 0.0077
SRP008496 POLD1 5424 RNAseq 1.0019 0.0161
SRP064894 POLD1 5424 RNAseq 1.4459 0.0000
SRP133303 POLD1 5424 RNAseq 0.9234 0.0001
SRP159526 POLD1 5424 RNAseq 1.1185 0.0020
SRP193095 POLD1 5424 RNAseq 0.9942 0.0000
SRP219564 POLD1 5424 RNAseq 1.2255 0.0033
TCGA POLD1 5424 RNAseq 0.5329 0.0000

Upregulated datasets: 7; Downregulated datasets: 0.  

 

Survival by POLD1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of POLD1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 POLD1 5424 4 4 22
GSE20123 POLD1 5424 4 3 23
GSE43470 POLD1 5424 4 11 28
GSE46452 POLD1 5424 45 1 13
GSE47630 POLD1 5424 9 6 25
GSE54993 POLD1 5424 17 4 49
GSE54994 POLD1 5424 4 14 35
GSE60625 POLD1 5424 9 0 2
GSE74703 POLD1 5424 4 7 25
GSE74704 POLD1 5424 4 1 15
TCGA POLD1 5424 14 19 63

Total number of gains: 118; Total number of losses: 70; Total Number of normals: 300.  

 

Somatic mutations of POLD1:

 

Generating mutation plots.

 

Highly correlated genes for POLD1:

 

Showing top 20/672 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
POLD1NPW0.765913303
POLD1USP490.754606303
POLD1TOX20.749549303
POLD1GTF2IRD20.74828606
POLD1CTU10.743055303
POLD1BEND30.736594606
POLD1ALKBH50.734863303
POLD1SHKBP10.732129404
POLD1HOXC90.731093606
POLD1BCL2L120.72446807
POLD1SAPCD20.718317404
POLD1CDCA50.717553707
POLD1CABP20.716703303
POLD1ANXA100.716036303
POLD1POLE40.712633504
POLD1SDK10.711946403
POLD1GDF70.711218303
POLD1YY20.709381303
POLD1TRIM110.708384504
POLD1KIF2C0.707284909

For details and further investigation, click here