| Full name: calcium/calmodulin dependent protein kinase I | Alias Symbol: CaMKI|CaMKI-alpha | ||
| Type: protein-coding gene | Cytoband: 3p25.3 | ||
| Entrez ID: 8536 | HGNC ID: HGNC:1459 | Ensembl Gene: ENSG00000134072 | OMIM ID: 604998 |
| Drug and gene relationship at DGIdb | |||
CAMK1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04921 | Oxytocin signaling pathway | |
| hsa04925 | Aldosterone synthesis and secretion |
Expression of CAMK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CAMK1 | 8536 | 204392_at | -0.3487 | 0.5955 | |
| GSE20347 | CAMK1 | 8536 | 204392_at | -0.0958 | 0.3786 | |
| GSE23400 | CAMK1 | 8536 | 204392_at | -0.2328 | 0.0003 | |
| GSE26886 | CAMK1 | 8536 | 204392_at | -0.0490 | 0.7272 | |
| GSE29001 | CAMK1 | 8536 | 204392_at | 0.1251 | 0.4108 | |
| GSE38129 | CAMK1 | 8536 | 204392_at | -0.3608 | 0.1449 | |
| GSE45670 | CAMK1 | 8536 | 204392_at | -0.3233 | 0.0028 | |
| GSE53622 | CAMK1 | 8536 | 97710 | -0.2606 | 0.0244 | |
| GSE53624 | CAMK1 | 8536 | 97710 | -0.0365 | 0.7835 | |
| GSE63941 | CAMK1 | 8536 | 204392_at | -0.7043 | 0.1512 | |
| GSE77861 | CAMK1 | 8536 | 204392_at | -0.1533 | 0.2202 | |
| GSE97050 | CAMK1 | 8536 | A_23_P121215 | -0.2671 | 0.3973 | |
| SRP007169 | CAMK1 | 8536 | RNAseq | 1.0860 | 0.0865 | |
| SRP008496 | CAMK1 | 8536 | RNAseq | 0.4871 | 0.2646 | |
| SRP064894 | CAMK1 | 8536 | RNAseq | 0.4788 | 0.1705 | |
| SRP133303 | CAMK1 | 8536 | RNAseq | -0.1281 | 0.5145 | |
| SRP159526 | CAMK1 | 8536 | RNAseq | -0.1788 | 0.5245 | |
| SRP193095 | CAMK1 | 8536 | RNAseq | 0.3850 | 0.0183 | |
| SRP219564 | CAMK1 | 8536 | RNAseq | -0.0298 | 0.9642 | |
| TCGA | CAMK1 | 8536 | RNAseq | -0.2852 | 0.0102 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CAMK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CAMK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CAMK1 | 8536 | 1 | 18 | 11 | |
| GSE20123 | CAMK1 | 8536 | 1 | 18 | 11 | |
| GSE43470 | CAMK1 | 8536 | 1 | 20 | 22 | |
| GSE46452 | CAMK1 | 8536 | 2 | 17 | 40 | |
| GSE47630 | CAMK1 | 8536 | 3 | 22 | 15 | |
| GSE54993 | CAMK1 | 8536 | 6 | 1 | 63 | |
| GSE54994 | CAMK1 | 8536 | 3 | 31 | 19 | |
| GSE60625 | CAMK1 | 8536 | 5 | 0 | 6 | |
| GSE74703 | CAMK1 | 8536 | 1 | 16 | 19 | |
| GSE74704 | CAMK1 | 8536 | 1 | 11 | 8 | |
| TCGA | CAMK1 | 8536 | 5 | 65 | 26 |
Total number of gains: 29; Total number of losses: 219; Total Number of normals: 240.
Somatic mutations of CAMK1:
Generating mutation plots.
Highly correlated genes for CAMK1:
Showing top 20/865 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CAMK1 | FUNDC2 | 0.799565 | 4 | 0 | 4 |
| CAMK1 | EPC2 | 0.796393 | 3 | 0 | 3 |
| CAMK1 | CELF6 | 0.792491 | 3 | 0 | 3 |
| CAMK1 | CD99L2 | 0.771004 | 4 | 0 | 4 |
| CAMK1 | TNFSF12 | 0.769303 | 4 | 0 | 4 |
| CAMK1 | FAM124A | 0.762918 | 5 | 0 | 5 |
| CAMK1 | RHOJ | 0.752003 | 4 | 0 | 4 |
| CAMK1 | TMOD1 | 0.749916 | 6 | 0 | 6 |
| CAMK1 | WFS1 | 0.748633 | 6 | 0 | 6 |
| CAMK1 | CYP2U1 | 0.737901 | 5 | 0 | 5 |
| CAMK1 | CYS1 | 0.726578 | 5 | 0 | 5 |
| CAMK1 | C19orf38 | 0.72621 | 3 | 0 | 3 |
| CAMK1 | GBA2 | 0.725285 | 3 | 0 | 3 |
| CAMK1 | NHSL2 | 0.724917 | 4 | 0 | 4 |
| CAMK1 | GIMAP5 | 0.724401 | 3 | 0 | 3 |
| CAMK1 | TCEAL6 | 0.721976 | 3 | 0 | 3 |
| CAMK1 | MMGT1 | 0.721897 | 3 | 0 | 3 |
| CAMK1 | PRKAB2 | 0.719052 | 3 | 0 | 3 |
| CAMK1 | SOX10 | 0.709963 | 3 | 0 | 3 |
| CAMK1 | FXYD1 | 0.708143 | 6 | 0 | 6 |
For details and further investigation, click here
