| Full name: cystin 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p25.1 | ||
| Entrez ID: 192668 | HGNC ID: HGNC:18525 | Ensembl Gene: ENSG00000205795 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of CYS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYS1 | 192668 | 228739_at | -0.9121 | 0.5217 | |
| GSE26886 | CYS1 | 192668 | 228739_at | 0.5484 | 0.0554 | |
| GSE45670 | CYS1 | 192668 | 228739_at | -1.5846 | 0.0001 | |
| GSE53622 | CYS1 | 192668 | 24427 | -0.6744 | 0.0046 | |
| GSE53624 | CYS1 | 192668 | 24427 | -0.3783 | 0.0333 | |
| GSE63941 | CYS1 | 192668 | 228739_at | -1.5397 | 0.0522 | |
| GSE77861 | CYS1 | 192668 | 228739_at | 0.0788 | 0.4629 | |
| GSE97050 | CYS1 | 192668 | A_33_P3398156 | -1.1894 | 0.1757 | |
| SRP007169 | CYS1 | 192668 | RNAseq | 1.3492 | 0.1249 | |
| SRP064894 | CYS1 | 192668 | RNAseq | -0.4435 | 0.2233 | |
| SRP133303 | CYS1 | 192668 | RNAseq | -0.1893 | 0.6498 | |
| SRP159526 | CYS1 | 192668 | RNAseq | 0.1789 | 0.7327 | |
| SRP219564 | CYS1 | 192668 | RNAseq | -1.2072 | 0.3054 | |
| TCGA | CYS1 | 192668 | RNAseq | -0.4848 | 0.0196 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CYS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYS1 | 192668 | 11 | 2 | 17 | |
| GSE20123 | CYS1 | 192668 | 11 | 2 | 17 | |
| GSE43470 | CYS1 | 192668 | 4 | 1 | 38 | |
| GSE46452 | CYS1 | 192668 | 3 | 4 | 52 | |
| GSE47630 | CYS1 | 192668 | 7 | 0 | 33 | |
| GSE54993 | CYS1 | 192668 | 0 | 7 | 63 | |
| GSE54994 | CYS1 | 192668 | 11 | 0 | 42 | |
| GSE60625 | CYS1 | 192668 | 0 | 3 | 8 | |
| GSE74703 | CYS1 | 192668 | 3 | 0 | 33 | |
| GSE74704 | CYS1 | 192668 | 9 | 1 | 10 | |
| TCGA | CYS1 | 192668 | 34 | 5 | 57 |
Total number of gains: 93; Total number of losses: 25; Total Number of normals: 370.
Somatic mutations of CYS1:
Generating mutation plots.
Highly correlated genes for CYS1:
Showing top 20/880 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYS1 | TMOD1 | 0.863718 | 4 | 0 | 4 |
| CYS1 | FXYD1 | 0.833324 | 3 | 0 | 3 |
| CYS1 | ILK | 0.817815 | 5 | 0 | 5 |
| CYS1 | TNFSF12 | 0.814396 | 3 | 0 | 3 |
| CYS1 | NKX6-1 | 0.80411 | 4 | 0 | 4 |
| CYS1 | SGCD | 0.798322 | 6 | 0 | 6 |
| CYS1 | OMD | 0.79781 | 5 | 0 | 5 |
| CYS1 | PARVA | 0.787245 | 6 | 0 | 6 |
| CYS1 | JAM3 | 0.78363 | 7 | 0 | 7 |
| CYS1 | ZCCHC24 | 0.783406 | 7 | 0 | 7 |
| CYS1 | DIXDC1 | 0.781086 | 6 | 0 | 6 |
| CYS1 | SYNC | 0.779067 | 4 | 0 | 4 |
| CYS1 | MRGPRF | 0.778459 | 7 | 0 | 7 |
| CYS1 | ATP10A | 0.774024 | 5 | 0 | 5 |
| CYS1 | SPOP | 0.771178 | 4 | 0 | 4 |
| CYS1 | AKAP6 | 0.770679 | 3 | 0 | 3 |
| CYS1 | CD34 | 0.769083 | 4 | 0 | 4 |
| CYS1 | PTH1R | 0.767056 | 4 | 0 | 4 |
| CYS1 | SMAD9 | 0.764838 | 7 | 0 | 7 |
| CYS1 | C1QTNF7 | 0.764611 | 5 | 0 | 5 |
For details and further investigation, click here
