PRKAB2

 

Full name: protein kinase AMP-activated non-catalytic subunit beta 2 Alias Symbol: 
Type: protein-coding gene Cytoband: 1q21.1
Entrez ID: 5565 HGNC ID: HGNC:9379 Ensembl Gene: ENSG00000131791 OMIM ID: 602741
Drug and gene relationship at DGIdb

 

PRKAB2 involved pathways:

KEGG pathway Description View
hsa04068FoxO signaling pathway
hsa04152AMPK signaling pathway
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04710Circadian rhythm
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04921Oxytocin signaling pathway
hsa04922Glucagon signaling pathway
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)

 

Expression of PRKAB2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PRKAB2 5565 225278_at 0.1889 0.8515
GSE20347 PRKAB2 5565 214474_at 0.3220 0.0102
GSE23400 PRKAB2 5565 214474_at 0.0948 0.0258
GSE26886 PRKAB2 5565 225278_at 1.2568 0.0000
GSE29001 PRKAB2 5565 214474_at 0.5743 0.1840
GSE38129 PRKAB2 5565 214474_at 0.2179 0.2997
GSE45670 PRKAB2 5565 225278_at 0.0605 0.8394
GSE53622 PRKAB2 5565 22675 0.4305 0.0037
GSE53624 PRKAB2 5565 22675 0.6828 0.0000
GSE63941 PRKAB2 5565 225278_at -0.3476 0.6513
GSE77861 PRKAB2 5565 225278_at 1.0154 0.0783
GSE97050 PRKAB2 5565 A_24_P105564 -0.3404 0.2994
SRP007169 PRKAB2 5565 RNAseq 2.2593 0.0000
SRP008496 PRKAB2 5565 RNAseq 2.3241 0.0000
SRP064894 PRKAB2 5565 RNAseq 0.5232 0.0078
SRP133303 PRKAB2 5565 RNAseq 0.8365 0.0004
SRP159526 PRKAB2 5565 RNAseq 0.3843 0.1380
SRP193095 PRKAB2 5565 RNAseq 0.4781 0.0065
SRP219564 PRKAB2 5565 RNAseq -0.0348 0.9461
TCGA PRKAB2 5565 RNAseq -0.2519 0.0000

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by PRKAB2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PRKAB2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PRKAB2 5565 12 0 18
GSE20123 PRKAB2 5565 12 0 18
GSE43470 PRKAB2 5565 5 1 37
GSE46452 PRKAB2 5565 2 1 56
GSE47630 PRKAB2 5565 12 2 26
GSE54993 PRKAB2 5565 0 2 68
GSE54994 PRKAB2 5565 15 0 38
GSE60625 PRKAB2 5565 0 0 11
GSE74703 PRKAB2 5565 5 1 30
GSE74704 PRKAB2 5565 6 0 14
TCGA PRKAB2 5565 33 15 48

Total number of gains: 102; Total number of losses: 22; Total Number of normals: 364.  

 

Somatic mutations of PRKAB2:

 

Generating mutation plots.

 

Highly correlated genes for PRKAB2:

 

Showing top 20/908 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PRKAB2ANKRD100.745531505
PRKAB2SAP30L0.738487404
PRKAB2ACYP10.738333303
PRKAB2ZNF518B0.728834303
PRKAB2TTC7B0.726077706
PRKAB2UBR50.725616303
PRKAB2PPP1R350.725404303
PRKAB2IVNS1ABP0.719783303
PRKAB2COX200.719485303
PRKAB2CAMK10.719052303
PRKAB2WDR50.717654303
PRKAB2SURF60.714043303
PRKAB2ASB20.709928404
PRKAB2SNTA10.708898303
PRKAB2MRPL400.705542303
PRKAB2C2orf690.701307303
PRKAB2METTL230.698237303
PRKAB2SPOPL0.697503504
PRKAB2KIF5B0.694616303
PRKAB2ZNF6090.690434303

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