| Full name: glucosylceramidase beta 2 | Alias Symbol: KIAA1605|AD035|DKFZp762K054 | ||
| Type: protein-coding gene | Cytoband: 9p13.3 | ||
| Entrez ID: 57704 | HGNC ID: HGNC:18986 | Ensembl Gene: ENSG00000070610 | OMIM ID: 609471 |
| Drug and gene relationship at DGIdb | |||
Expression of GBA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GBA2 | 57704 | 224627_at | -0.2547 | 0.5975 | |
| GSE26886 | GBA2 | 57704 | 224627_at | -0.4857 | 0.0026 | |
| GSE45670 | GBA2 | 57704 | 224627_at | -0.0388 | 0.8418 | |
| GSE53622 | GBA2 | 57704 | 13014 | -0.2373 | 0.0039 | |
| GSE53624 | GBA2 | 57704 | 13014 | -0.0783 | 0.2293 | |
| GSE63941 | GBA2 | 57704 | 223921_s_at | 0.4076 | 0.1577 | |
| GSE77861 | GBA2 | 57704 | 224627_at | -0.2612 | 0.0607 | |
| GSE97050 | GBA2 | 57704 | A_24_P341187 | -0.2974 | 0.3593 | |
| SRP007169 | GBA2 | 57704 | RNAseq | -0.3261 | 0.4255 | |
| SRP008496 | GBA2 | 57704 | RNAseq | -0.1622 | 0.5688 | |
| SRP064894 | GBA2 | 57704 | RNAseq | 0.1785 | 0.0373 | |
| SRP133303 | GBA2 | 57704 | RNAseq | -0.2809 | 0.0418 | |
| SRP159526 | GBA2 | 57704 | RNAseq | -0.5231 | 0.0015 | |
| SRP193095 | GBA2 | 57704 | RNAseq | -0.2376 | 0.2833 | |
| SRP219564 | GBA2 | 57704 | RNAseq | 0.0052 | 0.9866 | |
| TCGA | GBA2 | 57704 | RNAseq | -0.3805 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GBA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GBA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GBA2 | 57704 | 3 | 12 | 15 | |
| GSE20123 | GBA2 | 57704 | 3 | 12 | 15 | |
| GSE43470 | GBA2 | 57704 | 3 | 10 | 30 | |
| GSE46452 | GBA2 | 57704 | 6 | 15 | 38 | |
| GSE47630 | GBA2 | 57704 | 1 | 20 | 19 | |
| GSE54993 | GBA2 | 57704 | 6 | 0 | 64 | |
| GSE54994 | GBA2 | 57704 | 5 | 12 | 36 | |
| GSE60625 | GBA2 | 57704 | 0 | 0 | 11 | |
| GSE74703 | GBA2 | 57704 | 2 | 7 | 27 | |
| GSE74704 | GBA2 | 57704 | 0 | 10 | 10 | |
| TCGA | GBA2 | 57704 | 17 | 44 | 35 |
Total number of gains: 46; Total number of losses: 142; Total Number of normals: 300.
Somatic mutations of GBA2:
Generating mutation plots.
Highly correlated genes for GBA2:
Showing top 20/300 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GBA2 | CHCHD10 | 0.842918 | 3 | 0 | 3 |
| GBA2 | POU6F1 | 0.810909 | 3 | 0 | 3 |
| GBA2 | CNST | 0.800415 | 3 | 0 | 3 |
| GBA2 | KLF2 | 0.773977 | 3 | 0 | 3 |
| GBA2 | CCDC40 | 0.764927 | 3 | 0 | 3 |
| GBA2 | COX7B | 0.754768 | 3 | 0 | 3 |
| GBA2 | NDUFA3 | 0.750622 | 3 | 0 | 3 |
| GBA2 | FAM124A | 0.747185 | 3 | 0 | 3 |
| GBA2 | HDHD2 | 0.746467 | 4 | 0 | 4 |
| GBA2 | TAB1 | 0.743429 | 3 | 0 | 3 |
| GBA2 | ZNF529 | 0.73773 | 3 | 0 | 3 |
| GBA2 | DCUN1D4 | 0.737596 | 3 | 0 | 3 |
| GBA2 | MPP7 | 0.732683 | 3 | 0 | 3 |
| GBA2 | C9orf47 | 0.73241 | 3 | 0 | 3 |
| GBA2 | FBXO30 | 0.731551 | 3 | 0 | 3 |
| GBA2 | PPP1R15A | 0.730801 | 3 | 0 | 3 |
| GBA2 | CKMT2 | 0.730769 | 4 | 0 | 4 |
| GBA2 | BEND5 | 0.728306 | 3 | 0 | 3 |
| GBA2 | NDUFAF3 | 0.727933 | 3 | 0 | 3 |
| GBA2 | HIGD1A | 0.727508 | 3 | 0 | 3 |
For details and further investigation, click here
