| Full name: SRY-box transcription factor 10 | Alias Symbol: DOM|WS4|WS2E | ||
| Type: protein-coding gene | Cytoband: 22q13.1 | ||
| Entrez ID: 6663 | HGNC ID: HGNC:11190 | Ensembl Gene: ENSG00000100146 | OMIM ID: 602229 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SOX10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SOX10 | 6663 | 209843_s_at | -0.2664 | 0.4053 | |
| GSE20347 | SOX10 | 6663 | 209843_s_at | -0.1761 | 0.1590 | |
| GSE23400 | SOX10 | 6663 | 209842_at | -0.2881 | 0.0000 | |
| GSE26886 | SOX10 | 6663 | 209843_s_at | -0.1444 | 0.1754 | |
| GSE29001 | SOX10 | 6663 | 209842_at | -0.2604 | 0.5447 | |
| GSE38129 | SOX10 | 6663 | 209843_s_at | -0.3054 | 0.0070 | |
| GSE45670 | SOX10 | 6663 | 209843_s_at | -0.0152 | 0.9037 | |
| GSE63941 | SOX10 | 6663 | 209843_s_at | 0.3992 | 0.0035 | |
| GSE77861 | SOX10 | 6663 | 209843_s_at | -0.2592 | 0.0732 | |
| GSE97050 | SOX10 | 6663 | A_23_P143694 | -0.4518 | 0.3990 | |
| SRP133303 | SOX10 | 6663 | RNAseq | -1.3317 | 0.0262 | |
| SRP219564 | SOX10 | 6663 | RNAseq | -0.3905 | 0.7137 | |
| TCGA | SOX10 | 6663 | RNAseq | -1.1388 | 0.0154 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by SOX10 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SOX10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SOX10 | 6663 | 6 | 5 | 19 | |
| GSE20123 | SOX10 | 6663 | 6 | 4 | 20 | |
| GSE43470 | SOX10 | 6663 | 5 | 6 | 32 | |
| GSE46452 | SOX10 | 6663 | 32 | 2 | 25 | |
| GSE47630 | SOX10 | 6663 | 9 | 4 | 27 | |
| GSE54993 | SOX10 | 6663 | 3 | 6 | 61 | |
| GSE54994 | SOX10 | 6663 | 9 | 7 | 37 | |
| GSE60625 | SOX10 | 6663 | 5 | 0 | 6 | |
| GSE74703 | SOX10 | 6663 | 5 | 4 | 27 | |
| GSE74704 | SOX10 | 6663 | 3 | 2 | 15 | |
| TCGA | SOX10 | 6663 | 27 | 15 | 54 |
Total number of gains: 110; Total number of losses: 55; Total Number of normals: 323.
Somatic mutations of SOX10:
Generating mutation plots.
Highly correlated genes for SOX10:
Showing top 20/730 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SOX10 | ARHGEF25 | 0.780138 | 3 | 0 | 3 |
| SOX10 | TSPYL2 | 0.779668 | 3 | 0 | 3 |
| SOX10 | PIP5K1C | 0.758959 | 3 | 0 | 3 |
| SOX10 | STBD1 | 0.751935 | 3 | 0 | 3 |
| SOX10 | ITIH5 | 0.750171 | 3 | 0 | 3 |
| SOX10 | PLIN4 | 0.738437 | 3 | 0 | 3 |
| SOX10 | BTG2 | 0.736545 | 3 | 0 | 3 |
| SOX10 | ITGA7 | 0.731214 | 5 | 0 | 5 |
| SOX10 | HSPB7 | 0.725902 | 3 | 0 | 3 |
| SOX10 | NLRP12 | 0.721744 | 5 | 0 | 5 |
| SOX10 | SOX17 | 0.716644 | 3 | 0 | 3 |
| SOX10 | GSX1 | 0.716217 | 4 | 0 | 3 |
| SOX10 | CAMK1 | 0.709963 | 3 | 0 | 3 |
| SOX10 | WDR93 | 0.705997 | 4 | 0 | 4 |
| SOX10 | RNF148 | 0.702246 | 3 | 0 | 3 |
| SOX10 | SLC7A3 | 0.700267 | 3 | 0 | 3 |
| SOX10 | HRH2 | 0.700223 | 4 | 0 | 4 |
| SOX10 | FHL5 | 0.698997 | 3 | 0 | 3 |
| SOX10 | SOD3 | 0.693891 | 3 | 0 | 3 |
| SOX10 | HAND2-AS1 | 0.693636 | 5 | 0 | 5 |
For details and further investigation, click here
