| Full name: wolframin ER transmembrane glycoprotein | Alias Symbol: DIDMOAD|WFS | ||
| Type: protein-coding gene | Cytoband: 4p16.1 | ||
| Entrez ID: 7466 | HGNC ID: HGNC:12762 | Ensembl Gene: ENSG00000109501 | OMIM ID: 606201 |
| Drug and gene relationship at DGIdb | |||
Expression of WFS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WFS1 | 7466 | 202908_at | -0.1313 | 0.9094 | |
| GSE20347 | WFS1 | 7466 | 202908_at | 0.5751 | 0.0006 | |
| GSE23400 | WFS1 | 7466 | 202908_at | -0.3631 | 0.0056 | |
| GSE26886 | WFS1 | 7466 | 202908_at | 1.1203 | 0.0000 | |
| GSE29001 | WFS1 | 7466 | 202908_at | 0.6435 | 0.0106 | |
| GSE38129 | WFS1 | 7466 | 202908_at | -0.0040 | 0.9926 | |
| GSE45670 | WFS1 | 7466 | 202908_at | -0.3956 | 0.0382 | |
| GSE53622 | WFS1 | 7466 | 62335 | 0.0799 | 0.5474 | |
| GSE53624 | WFS1 | 7466 | 62335 | 0.4532 | 0.0000 | |
| GSE63941 | WFS1 | 7466 | 202908_at | -2.2147 | 0.0011 | |
| GSE77861 | WFS1 | 7466 | 202908_at | 0.1007 | 0.3735 | |
| GSE97050 | WFS1 | 7466 | A_23_P121499 | -0.7250 | 0.1894 | |
| SRP007169 | WFS1 | 7466 | RNAseq | 1.7128 | 0.0004 | |
| SRP008496 | WFS1 | 7466 | RNAseq | 2.2716 | 0.0000 | |
| SRP064894 | WFS1 | 7466 | RNAseq | 0.3255 | 0.1915 | |
| SRP133303 | WFS1 | 7466 | RNAseq | 0.0591 | 0.8389 | |
| SRP159526 | WFS1 | 7466 | RNAseq | 0.4039 | 0.3214 | |
| SRP193095 | WFS1 | 7466 | RNAseq | 0.4778 | 0.0869 | |
| SRP219564 | WFS1 | 7466 | RNAseq | -0.3760 | 0.6411 | |
| TCGA | WFS1 | 7466 | RNAseq | -0.3210 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by WFS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WFS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WFS1 | 7466 | 0 | 18 | 12 | |
| GSE20123 | WFS1 | 7466 | 0 | 18 | 12 | |
| GSE43470 | WFS1 | 7466 | 0 | 17 | 26 | |
| GSE46452 | WFS1 | 7466 | 1 | 36 | 22 | |
| GSE47630 | WFS1 | 7466 | 1 | 19 | 20 | |
| GSE54993 | WFS1 | 7466 | 10 | 0 | 60 | |
| GSE54994 | WFS1 | 7466 | 3 | 12 | 38 | |
| GSE60625 | WFS1 | 7466 | 0 | 0 | 11 | |
| GSE74703 | WFS1 | 7466 | 0 | 13 | 23 | |
| GSE74704 | WFS1 | 7466 | 0 | 10 | 10 | |
| TCGA | WFS1 | 7466 | 7 | 48 | 41 |
Total number of gains: 22; Total number of losses: 191; Total Number of normals: 275.
Somatic mutations of WFS1:
Generating mutation plots.
Highly correlated genes for WFS1:
Showing top 20/1127 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WFS1 | FXYD1 | 0.812311 | 4 | 0 | 4 |
| WFS1 | SYNC | 0.761938 | 6 | 0 | 6 |
| WFS1 | ENOX1 | 0.761441 | 6 | 0 | 6 |
| WFS1 | TMOD1 | 0.750936 | 6 | 0 | 5 |
| WFS1 | MGARP | 0.749599 | 3 | 0 | 3 |
| WFS1 | CAMK1 | 0.748633 | 6 | 0 | 6 |
| WFS1 | NBPF20 | 0.745792 | 3 | 0 | 3 |
| WFS1 | ILDR2 | 0.737938 | 3 | 0 | 3 |
| WFS1 | RCAN2 | 0.737107 | 6 | 0 | 5 |
| WFS1 | MEOX2 | 0.729698 | 5 | 0 | 4 |
| WFS1 | NFIX | 0.728579 | 3 | 0 | 3 |
| WFS1 | HINT2 | 0.72297 | 3 | 0 | 3 |
| WFS1 | SH3RF3 | 0.721887 | 5 | 0 | 5 |
| WFS1 | HERC2 | 0.718995 | 3 | 0 | 3 |
| WFS1 | PBXIP1 | 0.715865 | 9 | 0 | 8 |
| WFS1 | ARHGAP6 | 0.715333 | 7 | 0 | 6 |
| WFS1 | MITF | 0.712242 | 6 | 0 | 5 |
| WFS1 | MAP4 | 0.709784 | 5 | 0 | 5 |
| WFS1 | ZNF610 | 0.709254 | 3 | 0 | 3 |
| WFS1 | TLN1 | 0.708333 | 6 | 0 | 6 |
For details and further investigation, click here
