| Full name: cytochrome P450 family 2 subfamily U member 1 | Alias Symbol: SPG49 | ||
| Type: protein-coding gene | Cytoband: 4q25 | ||
| Entrez ID: 113612 | HGNC ID: HGNC:20582 | Ensembl Gene: ENSG00000155016 | OMIM ID: 610670 |
| Drug and gene relationship at DGIdb | |||
Expression of CYP2U1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP2U1 | 113612 | 226393_at | -0.2496 | 0.7546 | |
| GSE26886 | CYP2U1 | 113612 | 226402_at | 0.5563 | 0.2656 | |
| GSE45670 | CYP2U1 | 113612 | 226393_at | -0.3642 | 0.0239 | |
| GSE53622 | CYP2U1 | 113612 | 30677 | -1.0825 | 0.0000 | |
| GSE53624 | CYP2U1 | 113612 | 30677 | -1.0474 | 0.0000 | |
| GSE63941 | CYP2U1 | 113612 | 226393_at | -1.9341 | 0.0035 | |
| GSE77861 | CYP2U1 | 113612 | 226393_at | -0.0875 | 0.5462 | |
| GSE97050 | CYP2U1 | 113612 | A_33_P3252605 | -0.6409 | 0.1505 | |
| SRP007169 | CYP2U1 | 113612 | RNAseq | 0.6449 | 0.2426 | |
| SRP064894 | CYP2U1 | 113612 | RNAseq | -0.3456 | 0.2103 | |
| SRP133303 | CYP2U1 | 113612 | RNAseq | -0.2793 | 0.2289 | |
| SRP159526 | CYP2U1 | 113612 | RNAseq | -0.2540 | 0.2897 | |
| SRP193095 | CYP2U1 | 113612 | RNAseq | -0.4531 | 0.0484 | |
| SRP219564 | CYP2U1 | 113612 | RNAseq | -0.4082 | 0.5404 | |
| TCGA | CYP2U1 | 113612 | RNAseq | -0.5557 | 0.0004 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by CYP2U1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYP2U1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP2U1 | 113612 | 0 | 12 | 18 | |
| GSE20123 | CYP2U1 | 113612 | 0 | 12 | 18 | |
| GSE43470 | CYP2U1 | 113612 | 0 | 13 | 30 | |
| GSE46452 | CYP2U1 | 113612 | 1 | 36 | 22 | |
| GSE47630 | CYP2U1 | 113612 | 0 | 20 | 20 | |
| GSE54993 | CYP2U1 | 113612 | 9 | 0 | 61 | |
| GSE54994 | CYP2U1 | 113612 | 1 | 10 | 42 | |
| GSE60625 | CYP2U1 | 113612 | 0 | 3 | 8 | |
| GSE74703 | CYP2U1 | 113612 | 0 | 11 | 25 | |
| GSE74704 | CYP2U1 | 113612 | 0 | 6 | 14 | |
| TCGA | CYP2U1 | 113612 | 8 | 35 | 53 |
Total number of gains: 19; Total number of losses: 158; Total Number of normals: 311.
Somatic mutations of CYP2U1:
Generating mutation plots.
Highly correlated genes for CYP2U1:
Showing top 20/1262 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP2U1 | TNFSF12 | 0.883203 | 3 | 0 | 3 |
| CYP2U1 | TTC33 | 0.833944 | 3 | 0 | 3 |
| CYP2U1 | SORCS1 | 0.828329 | 4 | 0 | 4 |
| CYP2U1 | CLEC3B | 0.814706 | 3 | 0 | 3 |
| CYP2U1 | MBD5 | 0.813885 | 3 | 0 | 3 |
| CYP2U1 | FRMD3 | 0.808399 | 5 | 0 | 5 |
| CYP2U1 | FZD4 | 0.8028 | 5 | 0 | 5 |
| CYP2U1 | NR2F1 | 0.799877 | 3 | 0 | 3 |
| CYP2U1 | SAP18 | 0.798599 | 3 | 0 | 3 |
| CYP2U1 | EPHA3 | 0.79328 | 5 | 0 | 5 |
| CYP2U1 | CD34 | 0.792819 | 4 | 0 | 4 |
| CYP2U1 | CLIP3 | 0.790355 | 6 | 0 | 6 |
| CYP2U1 | FAM124A | 0.788808 | 4 | 0 | 4 |
| CYP2U1 | ALDH1A2 | 0.788187 | 4 | 0 | 4 |
| CYP2U1 | ADAMTS5 | 0.783303 | 6 | 0 | 6 |
| CYP2U1 | MEOX2 | 0.777057 | 6 | 0 | 5 |
| CYP2U1 | BHMT2 | 0.776581 | 6 | 0 | 6 |
| CYP2U1 | GPRASP2 | 0.776502 | 3 | 0 | 3 |
| CYP2U1 | JAM2 | 0.775781 | 6 | 0 | 6 |
| CYP2U1 | SGCD | 0.773329 | 6 | 0 | 6 |
For details and further investigation, click here
