| Full name: TNF superfamily member 12 | Alias Symbol: TWEAK|DR3LG|APO3L | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 8742 | HGNC ID: HGNC:11927 | Ensembl Gene: ENSG00000239697 | OMIM ID: 602695 |
| Drug and gene relationship at DGIdb | |||
Expression of TNFSF12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | TNFSF12 | 8742 | 25235 | -0.7542 | 0.0000 | |
| GSE53624 | TNFSF12 | 8742 | 25235 | -0.5059 | 0.0000 | |
| GSE97050 | TNFSF12 | 8742 | A_33_P3406623 | -0.6493 | 0.1450 | |
| SRP064894 | TNFSF12 | 8742 | RNAseq | 0.1247 | 0.7604 | |
| SRP133303 | TNFSF12 | 8742 | RNAseq | -0.4101 | 0.1983 | |
| SRP159526 | TNFSF12 | 8742 | RNAseq | -0.6531 | 0.0805 | |
| SRP193095 | TNFSF12 | 8742 | RNAseq | 0.3299 | 0.1110 | |
| SRP219564 | TNFSF12 | 8742 | RNAseq | -0.7414 | 0.3615 | |
| TCGA | TNFSF12 | 8742 | RNAseq | -0.4950 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TNFSF12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNFSF12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNFSF12 | 8742 | 4 | 2 | 24 | |
| GSE20123 | TNFSF12 | 8742 | 4 | 3 | 23 | |
| GSE43470 | TNFSF12 | 8742 | 1 | 4 | 38 | |
| GSE46452 | TNFSF12 | 8742 | 34 | 1 | 24 | |
| GSE47630 | TNFSF12 | 8742 | 7 | 1 | 32 | |
| GSE54993 | TNFSF12 | 8742 | 4 | 3 | 63 | |
| GSE54994 | TNFSF12 | 8742 | 5 | 8 | 40 | |
| GSE60625 | TNFSF12 | 8742 | 4 | 0 | 7 | |
| GSE74703 | TNFSF12 | 8742 | 1 | 2 | 33 | |
| GSE74704 | TNFSF12 | 8742 | 2 | 1 | 17 | |
| TCGA | TNFSF12 | 8742 | 17 | 21 | 58 |
Total number of gains: 83; Total number of losses: 46; Total Number of normals: 359.
Somatic mutations of TNFSF12:
Generating mutation plots.
Highly correlated genes for TNFSF12:
Showing top 20/534 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNFSF12 | CYP2U1 | 0.883203 | 3 | 0 | 3 |
| TNFSF12 | DIXDC1 | 0.867852 | 3 | 0 | 3 |
| TNFSF12 | ZCCHC24 | 0.867047 | 3 | 0 | 3 |
| TNFSF12 | NFATC4 | 0.84474 | 3 | 0 | 3 |
| TNFSF12 | RUNX1T1 | 0.83353 | 3 | 0 | 3 |
| TNFSF12 | ARRB1 | 0.826517 | 3 | 0 | 3 |
| TNFSF12 | CFL2 | 0.824556 | 3 | 0 | 3 |
| TNFSF12 | CELF2 | 0.814714 | 3 | 0 | 3 |
| TNFSF12 | CYS1 | 0.814396 | 3 | 0 | 3 |
| TNFSF12 | HSPB7 | 0.811106 | 3 | 0 | 3 |
| TNFSF12 | SLC16A4 | 0.808263 | 3 | 0 | 3 |
| TNFSF12 | NKX6-1 | 0.807309 | 3 | 0 | 3 |
| TNFSF12 | BHLHE22 | 0.804423 | 3 | 0 | 3 |
| TNFSF12 | PLCL1 | 0.804063 | 3 | 0 | 3 |
| TNFSF12 | TSPAN2 | 0.802474 | 3 | 0 | 3 |
| TNFSF12 | PIK3R1 | 0.801833 | 3 | 0 | 3 |
| TNFSF12 | RHOJ | 0.800715 | 3 | 0 | 3 |
| TNFSF12 | FAM124A | 0.800152 | 3 | 0 | 3 |
| TNFSF12 | CADM3 | 0.799573 | 3 | 0 | 3 |
| TNFSF12 | CLIP3 | 0.799453 | 4 | 0 | 4 |
For details and further investigation, click here
