| Full name: calcium sensing receptor | Alias Symbol: FHH|NSHPT|GPRC2A | ||
| Type: protein-coding gene | Cytoband: 3q13.33-q21.1 | ||
| Entrez ID: 846 | HGNC ID: HGNC:1514 | Ensembl Gene: ENSG00000036828 | OMIM ID: 601199 |
| Drug and gene relationship at DGIdb | |||
Expression of CASR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CASR | 846 | 210577_at | 0.0268 | 0.9436 | |
| GSE20347 | CASR | 846 | 210577_at | 0.0137 | 0.8820 | |
| GSE23400 | CASR | 846 | 210577_at | -0.0935 | 0.0304 | |
| GSE26886 | CASR | 846 | 240886_at | 0.1030 | 0.5077 | |
| GSE29001 | CASR | 846 | 210577_at | -0.2377 | 0.3383 | |
| GSE38129 | CASR | 846 | 210577_at | -0.0971 | 0.3312 | |
| GSE45670 | CASR | 846 | 240886_at | -0.0490 | 0.5712 | |
| GSE53622 | CASR | 846 | 67087 | -0.0972 | 0.4906 | |
| GSE53624 | CASR | 846 | 67087 | -0.0991 | 0.4328 | |
| GSE63941 | CASR | 846 | 210577_at | 0.1372 | 0.3943 | |
| GSE77861 | CASR | 846 | 240886_at | -0.1041 | 0.4812 | |
| SRP007169 | CASR | 846 | RNAseq | 0.4719 | 0.5950 | |
| SRP064894 | CASR | 846 | RNAseq | -1.5028 | 0.0000 | |
| SRP133303 | CASR | 846 | RNAseq | 0.0656 | 0.5098 | |
| SRP159526 | CASR | 846 | RNAseq | 0.5316 | 0.0574 | |
| SRP193095 | CASR | 846 | RNAseq | 0.1729 | 0.2725 | |
| SRP219564 | CASR | 846 | RNAseq | -0.1462 | 0.6806 | |
| TCGA | CASR | 846 | RNAseq | -2.0914 | 0.0072 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by CASR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CASR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CASR | 846 | 18 | 0 | 12 | |
| GSE20123 | CASR | 846 | 18 | 0 | 12 | |
| GSE43470 | CASR | 846 | 20 | 0 | 23 | |
| GSE46452 | CASR | 846 | 14 | 5 | 40 | |
| GSE47630 | CASR | 846 | 16 | 5 | 19 | |
| GSE54993 | CASR | 846 | 2 | 6 | 62 | |
| GSE54994 | CASR | 846 | 30 | 4 | 19 | |
| GSE60625 | CASR | 846 | 0 | 6 | 5 | |
| GSE74703 | CASR | 846 | 16 | 0 | 20 | |
| GSE74704 | CASR | 846 | 13 | 0 | 7 | |
| TCGA | CASR | 846 | 54 | 6 | 36 |
Total number of gains: 201; Total number of losses: 32; Total Number of normals: 255.
Somatic mutations of CASR:
Generating mutation plots.
Highly correlated genes for CASR:
Showing top 20/875 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CASR | ISLR2 | 0.76279 | 3 | 0 | 3 |
| CASR | SLC22A31 | 0.729308 | 3 | 0 | 3 |
| CASR | ARMC5 | 0.726442 | 4 | 0 | 4 |
| CASR | JSRP1 | 0.724304 | 3 | 0 | 3 |
| CASR | ISYNA1 | 0.722831 | 4 | 0 | 4 |
| CASR | ZNF696 | 0.716054 | 3 | 0 | 3 |
| CASR | ZNF358 | 0.709571 | 4 | 0 | 3 |
| CASR | AMN | 0.708512 | 5 | 0 | 4 |
| CASR | CYP3A4 | 0.700187 | 4 | 0 | 4 |
| CASR | REXO1 | 0.697355 | 3 | 0 | 3 |
| CASR | ADAMTS7 | 0.695961 | 6 | 0 | 5 |
| CASR | IGLL1 | 0.693978 | 4 | 0 | 4 |
| CASR | LINC00608 | 0.693096 | 3 | 0 | 3 |
| CASR | HKDC1 | 0.686407 | 5 | 0 | 5 |
| CASR | KCND3 | 0.685116 | 3 | 0 | 3 |
| CASR | TAS2R1 | 0.684529 | 3 | 0 | 3 |
| CASR | IGH | 0.682493 | 6 | 0 | 5 |
| CASR | NRG1 | 0.682133 | 4 | 0 | 4 |
| CASR | NEUROG1 | 0.677493 | 4 | 0 | 4 |
| CASR | SNX8 | 0.67704 | 3 | 0 | 3 |
For details and further investigation, click here
