| Full name: hexokinase domain containing 1 | Alias Symbol: FLJ37767|FLJ22761 | ||
| Type: protein-coding gene | Cytoband: 10q22.1 | ||
| Entrez ID: 80201 | HGNC ID: HGNC:23302 | Ensembl Gene: ENSG00000156510 | OMIM ID: 617221 |
| Drug and gene relationship at DGIdb | |||
HKDC1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04066 | HIF-1 signaling pathway | |
| hsa04910 | Insulin signaling pathway | |
| hsa04930 | Type II diabetes mellitus |
Expression of HKDC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HKDC1 | 80201 | 237323_at | 0.3820 | 0.6029 | |
| GSE20347 | HKDC1 | 80201 | 220585_at | 0.0260 | 0.6969 | |
| GSE23400 | HKDC1 | 80201 | 220585_at | -0.0697 | 0.0163 | |
| GSE26886 | HKDC1 | 80201 | 237324_s_at | 0.3341 | 0.0495 | |
| GSE29001 | HKDC1 | 80201 | 220585_at | 0.0054 | 0.9688 | |
| GSE38129 | HKDC1 | 80201 | 220585_at | -0.0149 | 0.8537 | |
| GSE45670 | HKDC1 | 80201 | 237324_s_at | -0.0625 | 0.5862 | |
| GSE53622 | HKDC1 | 80201 | 22090 | -0.5009 | 0.0000 | |
| GSE53624 | HKDC1 | 80201 | 22090 | -0.4830 | 0.0000 | |
| GSE63941 | HKDC1 | 80201 | 227614_at | 0.4940 | 0.6167 | |
| GSE77861 | HKDC1 | 80201 | 237324_s_at | -0.0894 | 0.7159 | |
| GSE97050 | HKDC1 | 80201 | A_33_P3335233 | -0.1512 | 0.5246 | |
| SRP133303 | HKDC1 | 80201 | RNAseq | 1.9495 | 0.0000 | |
| TCGA | HKDC1 | 80201 | RNAseq | -0.5600 | 0.3526 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by HKDC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HKDC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HKDC1 | 80201 | 3 | 4 | 23 | |
| GSE20123 | HKDC1 | 80201 | 3 | 3 | 24 | |
| GSE43470 | HKDC1 | 80201 | 1 | 7 | 35 | |
| GSE46452 | HKDC1 | 80201 | 0 | 11 | 48 | |
| GSE47630 | HKDC1 | 80201 | 2 | 14 | 24 | |
| GSE54993 | HKDC1 | 80201 | 7 | 0 | 63 | |
| GSE54994 | HKDC1 | 80201 | 2 | 12 | 39 | |
| GSE60625 | HKDC1 | 80201 | 0 | 0 | 11 | |
| GSE74703 | HKDC1 | 80201 | 1 | 4 | 31 | |
| GSE74704 | HKDC1 | 80201 | 1 | 1 | 18 | |
| TCGA | HKDC1 | 80201 | 11 | 22 | 63 |
Total number of gains: 31; Total number of losses: 78; Total Number of normals: 379.
Somatic mutations of HKDC1:
Generating mutation plots.
Highly correlated genes for HKDC1:
Showing top 20/391 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HKDC1 | GAL | 0.780619 | 3 | 0 | 3 |
| HKDC1 | HK1 | 0.761982 | 4 | 0 | 4 |
| HKDC1 | PLEKHA4 | 0.747484 | 3 | 0 | 3 |
| HKDC1 | LIPF | 0.722463 | 3 | 0 | 3 |
| HKDC1 | LYZL4 | 0.719578 | 3 | 0 | 3 |
| HKDC1 | TP53I11 | 0.718767 | 4 | 0 | 4 |
| HKDC1 | MAPK8IP3 | 0.715789 | 3 | 0 | 3 |
| HKDC1 | ZNF808 | 0.7145 | 3 | 0 | 3 |
| HKDC1 | ACAP1 | 0.713966 | 3 | 0 | 3 |
| HKDC1 | MZF1 | 0.713699 | 3 | 0 | 3 |
| HKDC1 | UNK | 0.711902 | 4 | 0 | 3 |
| HKDC1 | MAPK11 | 0.70757 | 4 | 0 | 4 |
| HKDC1 | BCAS4 | 0.706001 | 4 | 0 | 4 |
| HKDC1 | FHL3 | 0.705537 | 4 | 0 | 4 |
| HKDC1 | NCDN | 0.704767 | 4 | 0 | 4 |
| HKDC1 | SAMD1 | 0.704001 | 3 | 0 | 3 |
| HKDC1 | FAM86C1 | 0.701539 | 3 | 0 | 3 |
| HKDC1 | MICALCL | 0.700456 | 3 | 0 | 3 |
| HKDC1 | ZNF683 | 0.697347 | 3 | 0 | 3 |
| HKDC1 | PFDN1 | 0.689577 | 3 | 0 | 3 |
For details and further investigation, click here
