| Full name: cytochrome P450 family 3 subfamily A member 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 7q22.1 | ||
| Entrez ID: 1576 | HGNC ID: HGNC:2637 | Ensembl Gene: ENSG00000160868 | OMIM ID: 124010 |
| Drug and gene relationship at DGIdb | |||
Expression of CYP3A4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP3A4 | 1576 | 205998_x_at | 0.1814 | 0.5496 | |
| GSE20347 | CYP3A4 | 1576 | 205998_x_at | 0.2476 | 0.1163 | |
| GSE23400 | CYP3A4 | 1576 | 205998_x_at | -0.0569 | 0.3646 | |
| GSE26886 | CYP3A4 | 1576 | 205998_x_at | -0.0654 | 0.6333 | |
| GSE29001 | CYP3A4 | 1576 | 205998_x_at | -0.0776 | 0.6520 | |
| GSE38129 | CYP3A4 | 1576 | 205998_x_at | -0.0165 | 0.9340 | |
| GSE45670 | CYP3A4 | 1576 | 205998_x_at | 0.1054 | 0.2395 | |
| GSE53622 | CYP3A4 | 1576 | 68605 | -0.0338 | 0.6916 | |
| GSE53624 | CYP3A4 | 1576 | 68605 | -0.0004 | 0.9966 | |
| GSE63941 | CYP3A4 | 1576 | 205998_x_at | 0.0565 | 0.7337 | |
| GSE77861 | CYP3A4 | 1576 | 210726_at | -0.0984 | 0.3601 | |
| SRP133303 | CYP3A4 | 1576 | RNAseq | -0.9714 | 0.0013 | |
| SRP159526 | CYP3A4 | 1576 | RNAseq | -2.0771 | 0.0008 | |
| SRP193095 | CYP3A4 | 1576 | RNAseq | -2.1702 | 0.0000 | |
| TCGA | CYP3A4 | 1576 | RNAseq | -1.8950 | 0.0466 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by CYP3A4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYP3A4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP3A4 | 1576 | 13 | 0 | 17 | |
| GSE20123 | CYP3A4 | 1576 | 13 | 0 | 17 | |
| GSE43470 | CYP3A4 | 1576 | 6 | 1 | 36 | |
| GSE46452 | CYP3A4 | 1576 | 11 | 1 | 47 | |
| GSE47630 | CYP3A4 | 1576 | 7 | 3 | 30 | |
| GSE54993 | CYP3A4 | 1576 | 1 | 9 | 60 | |
| GSE54994 | CYP3A4 | 1576 | 16 | 3 | 34 | |
| GSE60625 | CYP3A4 | 1576 | 0 | 0 | 11 | |
| GSE74703 | CYP3A4 | 1576 | 6 | 1 | 29 | |
| GSE74704 | CYP3A4 | 1576 | 9 | 0 | 11 | |
| TCGA | CYP3A4 | 1576 | 53 | 5 | 38 |
Total number of gains: 135; Total number of losses: 23; Total Number of normals: 330.
Somatic mutations of CYP3A4:
Generating mutation plots.
Highly correlated genes for CYP3A4:
Showing top 20/709 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP3A4 | TAOK1 | 0.805898 | 4 | 0 | 4 |
| CYP3A4 | MAP3K19 | 0.770852 | 3 | 0 | 3 |
| CYP3A4 | CPNE6 | 0.765212 | 4 | 0 | 4 |
| CYP3A4 | PNMA3 | 0.75824 | 3 | 0 | 3 |
| CYP3A4 | MYO1G | 0.752569 | 3 | 0 | 3 |
| CYP3A4 | KIF5A | 0.748721 | 4 | 0 | 4 |
| CYP3A4 | DAB1 | 0.728333 | 5 | 0 | 5 |
| CYP3A4 | IFNA17 | 0.727453 | 4 | 0 | 4 |
| CYP3A4 | OR1A1 | 0.719747 | 3 | 0 | 3 |
| CYP3A4 | MAPK11 | 0.719036 | 4 | 0 | 4 |
| CYP3A4 | NEUROD2 | 0.717761 | 5 | 0 | 5 |
| CYP3A4 | GAD2 | 0.712965 | 4 | 0 | 4 |
| CYP3A4 | PODNL1 | 0.703437 | 7 | 0 | 6 |
| CYP3A4 | KIR3DL3 | 0.702113 | 5 | 0 | 5 |
| CYP3A4 | CASR | 0.700187 | 4 | 0 | 4 |
| CYP3A4 | HSF4 | 0.699555 | 3 | 0 | 3 |
| CYP3A4 | CER1 | 0.696905 | 4 | 0 | 4 |
| CYP3A4 | AQP2 | 0.695701 | 4 | 0 | 4 |
| CYP3A4 | CETN1 | 0.695683 | 4 | 0 | 4 |
| CYP3A4 | FOLH1 | 0.695145 | 4 | 0 | 3 |
For details and further investigation, click here
