| Full name: immunoglobulin superfamily containing leucine rich repeat 2 | Alias Symbol: KIAA1465 | ||
| Type: protein-coding gene | Cytoband: 15q24.1 | ||
| Entrez ID: 57611 | HGNC ID: HGNC:29286 | Ensembl Gene: ENSG00000167178 | OMIM ID: 614179 |
| Drug and gene relationship at DGIdb | |||
Expression of ISLR2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ISLR2 | 57611 | 232208_at | 0.0558 | 0.8942 | |
| GSE26886 | ISLR2 | 57611 | 232208_at | 0.3043 | 0.0387 | |
| GSE45670 | ISLR2 | 57611 | 232208_at | -0.0487 | 0.6954 | |
| GSE53622 | ISLR2 | 57611 | 2805 | 0.3302 | 0.0009 | |
| GSE53624 | ISLR2 | 57611 | 2805 | 0.0558 | 0.5650 | |
| GSE63941 | ISLR2 | 57611 | 232208_at | -0.2469 | 0.1802 | |
| GSE77861 | ISLR2 | 57611 | 232208_at | -0.1378 | 0.2888 | |
| GSE97050 | ISLR2 | 57611 | A_33_P3418091 | -0.2245 | 0.3606 | |
| SRP133303 | ISLR2 | 57611 | RNAseq | 1.0862 | 0.0000 | |
| SRP159526 | ISLR2 | 57611 | RNAseq | 1.4377 | 0.0009 | |
| SRP193095 | ISLR2 | 57611 | RNAseq | 0.2923 | 0.1610 | |
| SRP219564 | ISLR2 | 57611 | RNAseq | 0.6762 | 0.3941 | |
| TCGA | ISLR2 | 57611 | RNAseq | 0.0628 | 0.8004 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by ISLR2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ISLR2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ISLR2 | 57611 | 9 | 0 | 21 | |
| GSE20123 | ISLR2 | 57611 | 9 | 0 | 21 | |
| GSE43470 | ISLR2 | 57611 | 4 | 6 | 33 | |
| GSE46452 | ISLR2 | 57611 | 3 | 7 | 49 | |
| GSE47630 | ISLR2 | 57611 | 8 | 10 | 22 | |
| GSE54993 | ISLR2 | 57611 | 5 | 6 | 59 | |
| GSE54994 | ISLR2 | 57611 | 5 | 7 | 41 | |
| GSE60625 | ISLR2 | 57611 | 4 | 0 | 7 | |
| GSE74703 | ISLR2 | 57611 | 4 | 3 | 29 | |
| GSE74704 | ISLR2 | 57611 | 5 | 0 | 15 | |
| TCGA | ISLR2 | 57611 | 13 | 15 | 68 |
Total number of gains: 69; Total number of losses: 54; Total Number of normals: 365.
Somatic mutations of ISLR2:
Generating mutation plots.
Highly correlated genes for ISLR2:
Showing top 20/490 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ISLR2 | SLC25A47 | 0.867053 | 3 | 0 | 3 |
| ISLR2 | FAM171A2 | 0.825124 | 3 | 0 | 3 |
| ISLR2 | IGFN1 | 0.814422 | 3 | 0 | 3 |
| ISLR2 | REG3A | 0.806796 | 4 | 0 | 4 |
| ISLR2 | MPP2 | 0.803279 | 3 | 0 | 3 |
| ISLR2 | OR2B11 | 0.799777 | 3 | 0 | 3 |
| ISLR2 | PNMA3 | 0.79801 | 4 | 0 | 4 |
| ISLR2 | PDE6C | 0.79565 | 3 | 0 | 3 |
| ISLR2 | PRSS38 | 0.795633 | 3 | 0 | 3 |
| ISLR2 | YY2 | 0.786869 | 3 | 0 | 3 |
| ISLR2 | ADAMTS7 | 0.783293 | 3 | 0 | 3 |
| ISLR2 | DYTN | 0.779432 | 3 | 0 | 3 |
| ISLR2 | HK3 | 0.777316 | 3 | 0 | 3 |
| ISLR2 | BSX | 0.776981 | 3 | 0 | 3 |
| ISLR2 | CELF4 | 0.774873 | 3 | 0 | 3 |
| ISLR2 | MRGPRG | 0.77282 | 3 | 0 | 3 |
| ISLR2 | AOC2 | 0.771806 | 3 | 0 | 3 |
| ISLR2 | FUT7 | 0.771222 | 3 | 0 | 3 |
| ISLR2 | USP51 | 0.768829 | 3 | 0 | 3 |
| ISLR2 | FUZ | 0.764968 | 3 | 0 | 3 |
For details and further investigation, click here
