| Full name: ADAM metallopeptidase with thrombospondin type 1 motif 7 | Alias Symbol: ADAM-TS7|DKFZp434H204 | ||
| Type: protein-coding gene | Cytoband: 15q25.1 | ||
| Entrez ID: 11173 | HGNC ID: HGNC:223 | Ensembl Gene: ENSG00000136378 | OMIM ID: 605009 |
| Drug and gene relationship at DGIdb | |||
Expression of ADAMTS7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAMTS7 | 11173 | 220705_s_at | 0.0355 | 0.9148 | |
| GSE20347 | ADAMTS7 | 11173 | 220705_s_at | -0.0782 | 0.4241 | |
| GSE23400 | ADAMTS7 | 11173 | 220706_at | -0.1379 | 0.0004 | |
| GSE26886 | ADAMTS7 | 11173 | 220705_s_at | 0.1958 | 0.2213 | |
| GSE29001 | ADAMTS7 | 11173 | 220705_s_at | -0.0953 | 0.5268 | |
| GSE38129 | ADAMTS7 | 11173 | 220705_s_at | -0.1166 | 0.1246 | |
| GSE45670 | ADAMTS7 | 11173 | 220705_s_at | -0.0245 | 0.8530 | |
| GSE53622 | ADAMTS7 | 11173 | 84977 | -0.2624 | 0.0000 | |
| GSE53624 | ADAMTS7 | 11173 | 84977 | -0.3486 | 0.0000 | |
| GSE63941 | ADAMTS7 | 11173 | 220705_s_at | -0.1187 | 0.5938 | |
| GSE77861 | ADAMTS7 | 11173 | 220705_s_at | -0.1593 | 0.5027 | |
| GSE97050 | ADAMTS7 | 11173 | A_23_P11005 | 0.0950 | 0.6212 | |
| SRP007169 | ADAMTS7 | 11173 | RNAseq | 3.4092 | 0.0011 | |
| SRP064894 | ADAMTS7 | 11173 | RNAseq | 1.7799 | 0.0000 | |
| SRP133303 | ADAMTS7 | 11173 | RNAseq | 1.6779 | 0.0000 | |
| SRP159526 | ADAMTS7 | 11173 | RNAseq | 1.7321 | 0.0022 | |
| SRP193095 | ADAMTS7 | 11173 | RNAseq | 1.8053 | 0.0000 | |
| SRP219564 | ADAMTS7 | 11173 | RNAseq | 1.5221 | 0.0154 | |
| TCGA | ADAMTS7 | 11173 | RNAseq | 0.2429 | 0.0475 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by ADAMTS7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADAMTS7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAMTS7 | 11173 | 7 | 1 | 22 | |
| GSE20123 | ADAMTS7 | 11173 | 7 | 1 | 22 | |
| GSE43470 | ADAMTS7 | 11173 | 4 | 5 | 34 | |
| GSE46452 | ADAMTS7 | 11173 | 3 | 7 | 49 | |
| GSE47630 | ADAMTS7 | 11173 | 8 | 10 | 22 | |
| GSE54993 | ADAMTS7 | 11173 | 5 | 6 | 59 | |
| GSE54994 | ADAMTS7 | 11173 | 5 | 6 | 42 | |
| GSE60625 | ADAMTS7 | 11173 | 4 | 0 | 7 | |
| GSE74703 | ADAMTS7 | 11173 | 4 | 3 | 29 | |
| GSE74704 | ADAMTS7 | 11173 | 3 | 1 | 16 | |
| TCGA | ADAMTS7 | 11173 | 14 | 15 | 67 |
Total number of gains: 64; Total number of losses: 55; Total Number of normals: 369.
Somatic mutations of ADAMTS7:
Generating mutation plots.
Highly correlated genes for ADAMTS7:
Showing top 20/1055 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAMTS7 | ARHGAP30 | 0.876374 | 3 | 0 | 3 |
| ADAMTS7 | RASL10B | 0.816745 | 3 | 0 | 3 |
| ADAMTS7 | C19orf81 | 0.793637 | 3 | 0 | 3 |
| ADAMTS7 | SLC25A47 | 0.788373 | 3 | 0 | 3 |
| ADAMTS7 | ISLR2 | 0.783293 | 3 | 0 | 3 |
| ADAMTS7 | JSRP1 | 0.778168 | 4 | 0 | 4 |
| ADAMTS7 | CDH2 | 0.764855 | 3 | 0 | 3 |
| ADAMTS7 | MYLK2 | 0.74185 | 3 | 0 | 3 |
| ADAMTS7 | PTPRN2 | 0.741767 | 4 | 0 | 4 |
| ADAMTS7 | CELF4 | 0.737589 | 4 | 0 | 3 |
| ADAMTS7 | NKAIN4 | 0.737276 | 4 | 0 | 3 |
| ADAMTS7 | NPEPL1 | 0.735033 | 6 | 0 | 6 |
| ADAMTS7 | GATA2 | 0.730617 | 3 | 0 | 3 |
| ADAMTS7 | MYO18B | 0.730342 | 3 | 0 | 3 |
| ADAMTS7 | KBTBD13 | 0.728604 | 3 | 0 | 3 |
| ADAMTS7 | SCARF2 | 0.728378 | 6 | 0 | 5 |
| ADAMTS7 | MAFA | 0.727198 | 3 | 0 | 3 |
| ADAMTS7 | DPF1 | 0.726936 | 3 | 0 | 3 |
| ADAMTS7 | WNT9A | 0.721157 | 3 | 0 | 3 |
| ADAMTS7 | ZC3H10 | 0.717859 | 4 | 0 | 4 |
For details and further investigation, click here
