| Full name: neuregulin 1 | Alias Symbol: HRG|NDF|GGF | ||
| Type: protein-coding gene | Cytoband: 8p12 | ||
| Entrez ID: 3084 | HGNC ID: HGNC:7997 | Ensembl Gene: ENSG00000157168 | OMIM ID: 142445 |
| Drug and gene relationship at DGIdb | |||
NRG1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04012 | ErbB signaling pathway |
Expression of NRG1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NRG1 | 3084 | 206343_s_at | 1.6552 | 0.3128 | |
| GSE20347 | NRG1 | 3084 | 208241_at | 0.5488 | 0.0483 | |
| GSE23400 | NRG1 | 3084 | 208241_at | 0.7190 | 0.0000 | |
| GSE26886 | NRG1 | 3084 | 208232_x_at | 0.2297 | 0.1695 | |
| GSE29001 | NRG1 | 3084 | 206343_s_at | 2.0857 | 0.0155 | |
| GSE38129 | NRG1 | 3084 | 208232_x_at | -0.1158 | 0.3359 | |
| GSE45670 | NRG1 | 3084 | 208232_x_at | -0.2373 | 0.0246 | |
| GSE53622 | NRG1 | 3084 | 43987 | 1.8659 | 0.0000 | |
| GSE53624 | NRG1 | 3084 | 43987 | 1.6724 | 0.0000 | |
| GSE63941 | NRG1 | 3084 | 206343_s_at | 2.9316 | 0.0636 | |
| GSE77861 | NRG1 | 3084 | 208232_x_at | -0.1229 | 0.5338 | |
| GSE97050 | NRG1 | 3084 | A_33_P3284345 | 2.6120 | 0.1313 | |
| SRP007169 | NRG1 | 3084 | RNAseq | 3.3653 | 0.0001 | |
| SRP008496 | NRG1 | 3084 | RNAseq | 2.8243 | 0.0000 | |
| SRP064894 | NRG1 | 3084 | RNAseq | 2.3335 | 0.0000 | |
| SRP133303 | NRG1 | 3084 | RNAseq | 1.9827 | 0.0000 | |
| SRP159526 | NRG1 | 3084 | RNAseq | 2.7574 | 0.0009 | |
| SRP193095 | NRG1 | 3084 | RNAseq | 2.5339 | 0.0000 | |
| SRP219564 | NRG1 | 3084 | RNAseq | 2.4670 | 0.0084 | |
| TCGA | NRG1 | 3084 | RNAseq | 0.7328 | 0.0060 |
Upregulated datasets: 10; Downregulated datasets: 0.
Survival by NRG1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NRG1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NRG1 | 3084 | 5 | 10 | 15 | |
| GSE20123 | NRG1 | 3084 | 5 | 10 | 15 | |
| GSE43470 | NRG1 | 3084 | 4 | 7 | 32 | |
| GSE46452 | NRG1 | 3084 | 14 | 12 | 33 | |
| GSE47630 | NRG1 | 3084 | 10 | 8 | 22 | |
| GSE54993 | NRG1 | 3084 | 2 | 15 | 53 | |
| GSE54994 | NRG1 | 3084 | 11 | 15 | 27 | |
| GSE60625 | NRG1 | 3084 | 3 | 0 | 8 | |
| GSE74703 | NRG1 | 3084 | 4 | 6 | 26 | |
| GSE74704 | NRG1 | 3084 | 4 | 6 | 10 | |
| TCGA | NRG1 | 3084 | 24 | 37 | 35 |
Total number of gains: 86; Total number of losses: 126; Total Number of normals: 276.
Somatic mutations of NRG1:
Generating mutation plots.
Highly correlated genes for NRG1:
Showing top 20/415 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NRG1 | JSRP1 | 0.765826 | 3 | 0 | 3 |
| NRG1 | GNAT1 | 0.737981 | 4 | 0 | 4 |
| NRG1 | CYP11B2 | 0.736493 | 4 | 0 | 4 |
| NRG1 | EVX1 | 0.735359 | 4 | 0 | 4 |
| NRG1 | GDAP1L1 | 0.734039 | 3 | 0 | 3 |
| NRG1 | NPEPL1 | 0.73261 | 5 | 0 | 5 |
| NRG1 | FUT7 | 0.721339 | 5 | 0 | 5 |
| NRG1 | DUX1 | 0.704259 | 4 | 0 | 4 |
| NRG1 | OXCT2 | 0.704242 | 3 | 0 | 3 |
| NRG1 | ELAVL3 | 0.699998 | 4 | 0 | 4 |
| NRG1 | ZNF646 | 0.698406 | 4 | 0 | 3 |
| NRG1 | DPYSL4 | 0.698362 | 3 | 0 | 3 |
| NRG1 | ADAMTS14 | 0.696239 | 4 | 0 | 4 |
| NRG1 | MLXIPL | 0.693339 | 3 | 0 | 3 |
| NRG1 | AMER3 | 0.690339 | 3 | 0 | 3 |
| NRG1 | ISYNA1 | 0.689333 | 3 | 0 | 3 |
| NRG1 | AMN | 0.686363 | 4 | 0 | 3 |
| NRG1 | ITGA2B | 0.686245 | 3 | 0 | 3 |
| NRG1 | CASR | 0.682133 | 4 | 0 | 4 |
| NRG1 | LRRC73 | 0.67856 | 3 | 0 | 3 |
For details and further investigation, click here
