| Full name: inositol-3-phosphate synthase 1 | Alias Symbol: Ino1|INOS|IPS | ||
| Type: protein-coding gene | Cytoband: 19p13.11 | ||
| Entrez ID: 51477 | HGNC ID: HGNC:29821 | Ensembl Gene: ENSG00000105655 | OMIM ID: 611670 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ISYNA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ISYNA1 | 51477 | 222240_s_at | 0.4809 | 0.5762 | |
| GSE20347 | ISYNA1 | 51477 | 222240_s_at | 0.6250 | 0.0011 | |
| GSE23400 | ISYNA1 | 51477 | 222240_s_at | 0.5350 | 0.0008 | |
| GSE26886 | ISYNA1 | 51477 | 229324_x_at | 0.1523 | 0.4024 | |
| GSE29001 | ISYNA1 | 51477 | 222240_s_at | 0.5773 | 0.1722 | |
| GSE38129 | ISYNA1 | 51477 | 222240_s_at | 0.6148 | 0.0006 | |
| GSE45670 | ISYNA1 | 51477 | 229324_x_at | -0.0226 | 0.8553 | |
| GSE53622 | ISYNA1 | 51477 | 81497 | 0.3604 | 0.0001 | |
| GSE53624 | ISYNA1 | 51477 | 81497 | 0.5249 | 0.0000 | |
| GSE63941 | ISYNA1 | 51477 | 222240_s_at | 3.1226 | 0.0216 | |
| GSE77861 | ISYNA1 | 51477 | 229324_x_at | -0.2108 | 0.2992 | |
| GSE97050 | ISYNA1 | 51477 | A_33_P3306504 | -0.0272 | 0.9411 | |
| SRP007169 | ISYNA1 | 51477 | RNAseq | 1.9936 | 0.0019 | |
| SRP008496 | ISYNA1 | 51477 | RNAseq | 2.2248 | 0.0000 | |
| SRP064894 | ISYNA1 | 51477 | RNAseq | 0.7964 | 0.0118 | |
| SRP133303 | ISYNA1 | 51477 | RNAseq | -0.5433 | 0.0011 | |
| SRP193095 | ISYNA1 | 51477 | RNAseq | 1.0494 | 0.0000 | |
| SRP219564 | ISYNA1 | 51477 | RNAseq | 0.2191 | 0.7423 | |
| TCGA | ISYNA1 | 51477 | RNAseq | 0.2942 | 0.0210 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by ISYNA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ISYNA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ISYNA1 | 51477 | 4 | 4 | 22 | |
| GSE20123 | ISYNA1 | 51477 | 3 | 2 | 25 | |
| GSE43470 | ISYNA1 | 51477 | 2 | 5 | 36 | |
| GSE46452 | ISYNA1 | 51477 | 47 | 1 | 11 | |
| GSE47630 | ISYNA1 | 51477 | 4 | 8 | 28 | |
| GSE54993 | ISYNA1 | 51477 | 15 | 4 | 51 | |
| GSE54994 | ISYNA1 | 51477 | 6 | 13 | 34 | |
| GSE60625 | ISYNA1 | 51477 | 9 | 0 | 2 | |
| GSE74703 | ISYNA1 | 51477 | 2 | 3 | 31 | |
| GSE74704 | ISYNA1 | 51477 | 0 | 2 | 18 | |
| TCGA | ISYNA1 | 51477 | 16 | 10 | 70 |
Total number of gains: 108; Total number of losses: 52; Total Number of normals: 328.
Somatic mutations of ISYNA1:
Generating mutation plots.
Highly correlated genes for ISYNA1:
Showing top 20/300 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ISYNA1 | IGH | 0.762255 | 3 | 0 | 3 |
| ISYNA1 | KCNF1 | 0.75699 | 4 | 0 | 4 |
| ISYNA1 | FBXO15 | 0.739238 | 3 | 0 | 3 |
| ISYNA1 | CABP1 | 0.735675 | 3 | 0 | 3 |
| ISYNA1 | IGFN1 | 0.733856 | 3 | 0 | 3 |
| ISYNA1 | DNAH9 | 0.731479 | 4 | 0 | 3 |
| ISYNA1 | CASR | 0.722831 | 4 | 0 | 4 |
| ISYNA1 | DHRS7C | 0.714986 | 3 | 0 | 3 |
| ISYNA1 | REG3A | 0.713934 | 3 | 0 | 3 |
| ISYNA1 | NTRK1 | 0.713506 | 4 | 0 | 3 |
| ISYNA1 | GJD4 | 0.712859 | 4 | 0 | 4 |
| ISYNA1 | JSRP1 | 0.711144 | 4 | 0 | 4 |
| ISYNA1 | PEX11G | 0.705182 | 3 | 0 | 3 |
| ISYNA1 | MUC8 | 0.702852 | 3 | 0 | 3 |
| ISYNA1 | FUZ | 0.700051 | 3 | 0 | 3 |
| ISYNA1 | CD300LG | 0.698724 | 3 | 0 | 3 |
| ISYNA1 | CDH23 | 0.696132 | 4 | 0 | 3 |
| ISYNA1 | SORCS2 | 0.695814 | 4 | 0 | 4 |
| ISYNA1 | CACNA1H | 0.692905 | 3 | 0 | 3 |
| ISYNA1 | SEMA3B | 0.691828 | 5 | 0 | 4 |
For details and further investigation, click here
