| Full name: choline phosphotransferase 1 | Alias Symbol: CPT1 | ||
| Type: protein-coding gene | Cytoband: 12q23.2 | ||
| Entrez ID: 56994 | HGNC ID: HGNC:17852 | Ensembl Gene: ENSG00000111666 | OMIM ID: 616747 |
| Drug and gene relationship at DGIdb | |||
Expression of CHPT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHPT1 | 56994 | 221675_s_at | -0.9701 | 0.1327 | |
| GSE20347 | CHPT1 | 56994 | 221675_s_at | -0.7952 | 0.0004 | |
| GSE23400 | CHPT1 | 56994 | 221675_s_at | -0.6685 | 0.0000 | |
| GSE26886 | CHPT1 | 56994 | 221675_s_at | -0.8804 | 0.0570 | |
| GSE29001 | CHPT1 | 56994 | 221675_s_at | -0.7329 | 0.1201 | |
| GSE38129 | CHPT1 | 56994 | 221675_s_at | -0.8003 | 0.0000 | |
| GSE45670 | CHPT1 | 56994 | 221675_s_at | -1.6335 | 0.0002 | |
| GSE53622 | CHPT1 | 56994 | 54684 | -0.3747 | 0.0000 | |
| GSE53624 | CHPT1 | 56994 | 54684 | -0.6720 | 0.0000 | |
| GSE63941 | CHPT1 | 56994 | 221675_s_at | -1.7767 | 0.0005 | |
| GSE77861 | CHPT1 | 56994 | 221675_s_at | -0.6044 | 0.0735 | |
| GSE97050 | CHPT1 | 56994 | A_23_P105571 | -0.3471 | 0.1619 | |
| SRP007169 | CHPT1 | 56994 | RNAseq | -1.4245 | 0.0058 | |
| SRP008496 | CHPT1 | 56994 | RNAseq | -1.3133 | 0.0001 | |
| SRP064894 | CHPT1 | 56994 | RNAseq | -1.1642 | 0.0000 | |
| SRP133303 | CHPT1 | 56994 | RNAseq | -0.5493 | 0.1281 | |
| SRP159526 | CHPT1 | 56994 | RNAseq | -0.1118 | 0.8386 | |
| SRP193095 | CHPT1 | 56994 | RNAseq | -0.8397 | 0.0036 | |
| SRP219564 | CHPT1 | 56994 | RNAseq | -1.0900 | 0.0149 | |
| TCGA | CHPT1 | 56994 | RNAseq | -0.6192 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by CHPT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHPT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHPT1 | 56994 | 2 | 2 | 26 | |
| GSE20123 | CHPT1 | 56994 | 2 | 2 | 26 | |
| GSE43470 | CHPT1 | 56994 | 2 | 0 | 41 | |
| GSE46452 | CHPT1 | 56994 | 9 | 1 | 49 | |
| GSE47630 | CHPT1 | 56994 | 9 | 1 | 30 | |
| GSE54993 | CHPT1 | 56994 | 0 | 5 | 65 | |
| GSE54994 | CHPT1 | 56994 | 4 | 2 | 47 | |
| GSE60625 | CHPT1 | 56994 | 0 | 0 | 11 | |
| GSE74703 | CHPT1 | 56994 | 2 | 0 | 34 | |
| GSE74704 | CHPT1 | 56994 | 1 | 2 | 17 | |
| TCGA | CHPT1 | 56994 | 18 | 10 | 68 |
Total number of gains: 49; Total number of losses: 25; Total Number of normals: 414.
Somatic mutations of CHPT1:
Generating mutation plots.
Highly correlated genes for CHPT1:
Showing top 20/895 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHPT1 | FBXL3 | 0.684438 | 5 | 0 | 4 |
| CHPT1 | RABL3 | 0.682613 | 3 | 0 | 3 |
| CHPT1 | RNPC3 | 0.678516 | 3 | 0 | 3 |
| CHPT1 | CTR9 | 0.673524 | 4 | 0 | 4 |
| CHPT1 | NR3C2 | 0.668985 | 11 | 0 | 10 |
| CHPT1 | PARD3B | 0.66897 | 5 | 0 | 4 |
| CHPT1 | NEGR1 | 0.664392 | 5 | 0 | 5 |
| CHPT1 | GYPC | 0.663298 | 9 | 0 | 9 |
| CHPT1 | TAF9B | 0.659982 | 3 | 0 | 3 |
| CHPT1 | MTFR1L | 0.658685 | 6 | 0 | 6 |
| CHPT1 | FAM13C | 0.657676 | 6 | 0 | 6 |
| CHPT1 | CRBN | 0.65526 | 7 | 0 | 5 |
| CHPT1 | PPM1L | 0.654913 | 6 | 0 | 5 |
| CHPT1 | SLTM | 0.649805 | 7 | 0 | 7 |
| CHPT1 | TMEM218 | 0.649613 | 4 | 0 | 4 |
| CHPT1 | TBX5-AS1 | 0.64766 | 3 | 0 | 3 |
| CHPT1 | ZNF33B | 0.645415 | 6 | 0 | 5 |
| CHPT1 | CASP3 | 0.644942 | 4 | 0 | 4 |
| CHPT1 | ZNF44 | 0.64454 | 4 | 0 | 4 |
| CHPT1 | MIF4GD | 0.64406 | 3 | 0 | 3 |
For details and further investigation, click here
