Full name: caspase 3	Alias Symbol: CPP32|CPP32B|Yama|apopain
Type: protein-coding gene	Cytoband: 4q35.1
Entrez ID: 836	HGNC ID: HGNC:1504	Ensembl Gene: ENSG00000164305	OMIM ID: 600636
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 8/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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CASP3 involved pathways:

KEGG pathway	Description	View
hsa04010	MAPK signaling pathway	View
hsa04115	p53 signaling pathway	View
hsa04210	Apoptosis	View
hsa04650	Natural killer cell mediated cytotoxicity	View
hsa04668	TNF signaling pathway	View
hsa04726	Serotonergic synapse	View
hsa04932	Non-alcoholic fatty liver disease (NAFLD)	View
hsa04933	AGE-RAGE signaling pathway in diabetic complications	View
hsa05010	Alzheimer's disease	View
hsa05012	Parkinson's disease	View
hsa05014	Amyotrophic lateral sclerosis (ALS)	View
hsa05016	Huntington's disease	View
hsa05134	Legionellosis	View
hsa05145	Toxoplasmosis	View
hsa05152	Tuberculosis	View
hsa05161	Hepatitis B	View
hsa05168	Herpes simplex infection	View
hsa05200	Pathways in cancer	View
hsa05205	Proteoglycans in cancer	View
hsa05210	Colorectal cancer	View

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Expression of CASP3:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	CASP3	836	202763_at	0.0523	0.9556	Show
GSE20347	CASP3	836	202763_at	-0.2995	0.0098	Show
GSE23400	CASP3	836	202763_at	-0.1648	0.0123	Show
GSE26886	CASP3	836	202763_at	-0.8388	0.0001	Show
GSE29001	CASP3	836	202763_at	-0.3897	0.3747	Show
GSE38129	CASP3	836	202763_at	-0.0110	0.9506	Show
GSE45670	CASP3	836	202763_at	0.0032	0.9897	Show
GSE53622	CASP3	836	153401	-0.1726	0.0880	Show
GSE53624	CASP3	836	153401	-0.3107	0.0000	Show
GSE63941	CASP3	836	202763_at	-0.3918	0.4536	Show
GSE77861	CASP3	836	202763_at	0.1038	0.7740	Show
GSE97050	CASP3	836	A_33_P3278118	-0.0545	0.9086	Show
SRP007169	CASP3	836	RNAseq	-0.2681	0.5084	Show
SRP008496	CASP3	836	RNAseq	-0.2192	0.3035	Show
SRP064894	CASP3	836	RNAseq	-0.3968	0.0141	Show
SRP133303	CASP3	836	RNAseq	0.3249	0.1426	Show
SRP159526	CASP3	836	RNAseq	0.0141	0.9617	Show
SRP193095	CASP3	836	RNAseq	-0.8175	0.0000	Show
SRP219564	CASP3	836	RNAseq	-0.7121	0.0501	Show
TCGA	CASP3	836	RNAseq	0.1033	0.0479	Show

Upregulated datasets: 0; Downregulated datasets: 0.  Download Data

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Survival by CASP3 expression:

 

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Copy number change of CASP3:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	CASP3	836	3	12	15	Show
GSE20123	CASP3	836	3	12	15	Show
GSE43470	CASP3	836	1	12	30	Show
GSE46452	CASP3	836	1	36	22	Show
GSE47630	CASP3	836	0	22	18	Show
GSE54993	CASP3	836	10	0	60	Show
GSE54994	CASP3	836	2	12	39	Show
GSE60625	CASP3	836	0	0	11	Show
GSE74703	CASP3	836	1	9	26	Show
GSE74704	CASP3	836	1	5	14	Show
TCGA	CASP3	836	11	32	53	Show

Total number of gains: 33; Total number of losses: 152; Total Number of normals: 303.  Download Data

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Somatic mutations of CASP3:

 

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Highly correlated genes for CASP3:

 

Showing top 20/714 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
CASP3	DUSP16	0.816998	3	0	3
CASP3	LIPT1	0.804863	3	0	3
CASP3	PPM1D	0.790585	3	0	3
CASP3	REST	0.772438	3	0	3
CASP3	LYRM1	0.760899	3	0	3
CASP3	SLC25A24	0.742791	3	0	3
CASP3	ASCC3	0.7375	3	0	3
CASP3	MBNL3	0.731456	5	0	5
CASP3	ELP4	0.723805	3	0	3
CASP3	HDHD2	0.721741	3	0	3
CASP3	DUSP18	0.718549	3	0	3
CASP3	SCAMP3	0.711948	3	0	3
CASP3	GPRIN3	0.70843	3	0	3
CASP3	EIF2AK3	0.70636	4	0	4
CASP3	AZI2	0.70346	4	0	4
CASP3	NXT2	0.703196	4	0	4
CASP3	DCAF12	0.698171	5	0	4
CASP3	PPP2R5E	0.697676	3	0	3
CASP3	CPT2	0.695809	5	0	4
CASP3	NUP54	0.695711	4	0	3

For details and further investigation, click here