| Full name: F-box and leucine rich repeat protein 3 | Alias Symbol: FBL3|FBL3A | ||
| Type: protein-coding gene | Cytoband: 13q22.3 | ||
| Entrez ID: 26224 | HGNC ID: HGNC:13599 | Ensembl Gene: ENSG00000005812 | OMIM ID: 605653 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
FBXL3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04710 | Circadian rhythm |
Expression of FBXL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FBXL3 | 26224 | 225132_at | -0.7321 | 0.0291 | |
| GSE26886 | FBXL3 | 26224 | 225132_at | -0.6063 | 0.0445 | |
| GSE45670 | FBXL3 | 26224 | 225132_at | -0.6557 | 0.0000 | |
| GSE63941 | FBXL3 | 26224 | 225132_at | -0.9777 | 0.0105 | |
| GSE77861 | FBXL3 | 26224 | 225132_at | -0.6261 | 0.0171 | |
| GSE97050 | FBXL3 | 26224 | A_23_P140069 | -0.3021 | 0.1903 | |
| SRP007169 | FBXL3 | 26224 | RNAseq | -1.3551 | 0.0002 | |
| SRP008496 | FBXL3 | 26224 | RNAseq | -1.0836 | 0.0000 | |
| SRP064894 | FBXL3 | 26224 | RNAseq | -0.5767 | 0.0121 | |
| SRP133303 | FBXL3 | 26224 | RNAseq | 0.0273 | 0.9010 | |
| SRP159526 | FBXL3 | 26224 | RNAseq | -0.7895 | 0.0473 | |
| SRP193095 | FBXL3 | 26224 | RNAseq | -0.7767 | 0.0000 | |
| SRP219564 | FBXL3 | 26224 | RNAseq | -0.5341 | 0.0419 | |
| TCGA | FBXL3 | 26224 | RNAseq | -0.0985 | 0.0322 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by FBXL3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of FBXL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FBXL3 | 26224 | 3 | 11 | 16 | |
| GSE20123 | FBXL3 | 26224 | 3 | 10 | 17 | |
| GSE43470 | FBXL3 | 26224 | 4 | 11 | 28 | |
| GSE46452 | FBXL3 | 26224 | 0 | 32 | 27 | |
| GSE47630 | FBXL3 | 26224 | 3 | 27 | 10 | |
| GSE54993 | FBXL3 | 26224 | 11 | 3 | 56 | |
| GSE54994 | FBXL3 | 26224 | 3 | 15 | 35 | |
| GSE60625 | FBXL3 | 26224 | 0 | 3 | 8 | |
| GSE74703 | FBXL3 | 26224 | 3 | 9 | 24 | |
| GSE74704 | FBXL3 | 26224 | 1 | 9 | 10 | |
| TCGA | FBXL3 | 26224 | 12 | 33 | 51 |
Total number of gains: 43; Total number of losses: 163; Total Number of normals: 282.
Somatic mutations of FBXL3:
Generating mutation plots.
Highly correlated genes for FBXL3:
Showing top 20/1161 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FBXL3 | RAD17 | 0.878368 | 3 | 0 | 3 |
| FBXL3 | C7 | 0.865061 | 3 | 0 | 3 |
| FBXL3 | GPBP1 | 0.861564 | 3 | 0 | 3 |
| FBXL3 | CRBN | 0.854067 | 5 | 0 | 5 |
| FBXL3 | CETN3 | 0.829168 | 3 | 0 | 3 |
| FBXL3 | NPY1R | 0.827382 | 3 | 0 | 3 |
| FBXL3 | TGFBR3 | 0.802228 | 3 | 0 | 3 |
| FBXL3 | ZBTB16 | 0.795889 | 3 | 0 | 3 |
| FBXL3 | ZNF92 | 0.793108 | 3 | 0 | 3 |
| FBXL3 | PRELP | 0.791274 | 3 | 0 | 3 |
| FBXL3 | NFASC | 0.787196 | 3 | 0 | 3 |
| FBXL3 | GNG7 | 0.785138 | 3 | 0 | 3 |
| FBXL3 | CILP | 0.783259 | 3 | 0 | 3 |
| FBXL3 | ITGA9 | 0.782467 | 3 | 0 | 3 |
| FBXL3 | FHL5 | 0.781937 | 3 | 0 | 3 |
| FBXL3 | CASQ2 | 0.78136 | 3 | 0 | 3 |
| FBXL3 | SMARCA2 | 0.780641 | 5 | 0 | 5 |
| FBXL3 | CUL4B | 0.780592 | 5 | 0 | 5 |
| FBXL3 | USP25 | 0.779649 | 4 | 0 | 4 |
| FBXL3 | TCEAL1 | 0.779276 | 3 | 0 | 3 |
For details and further investigation, click here
