| Full name: nuclear receptor subfamily 3 group C member 2 | Alias Symbol: MR | ||
| Type: protein-coding gene | Cytoband: 4q31 | ||
| Entrez ID: 4306 | HGNC ID: HGNC:7979 | Ensembl Gene: ENSG00000151623 | OMIM ID: 600983 |
| Drug and gene relationship at DGIdb | |||
NR3C2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04960 | Aldosterone-regulated sodium reabsorption |
Expression of NR3C2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NR3C2 | 4306 | 205259_at | -1.1341 | 0.4015 | |
| GSE20347 | NR3C2 | 4306 | 205259_at | -0.6721 | 0.0002 | |
| GSE23400 | NR3C2 | 4306 | 205259_at | -0.2572 | 0.0000 | |
| GSE26886 | NR3C2 | 4306 | 205259_at | -0.0571 | 0.9116 | |
| GSE29001 | NR3C2 | 4306 | 205259_at | -1.0685 | 0.0077 | |
| GSE38129 | NR3C2 | 4306 | 205259_at | -1.3599 | 0.0000 | |
| GSE45670 | NR3C2 | 4306 | 205259_at | -2.5606 | 0.0000 | |
| GSE53622 | NR3C2 | 4306 | 108786 | -2.0502 | 0.0000 | |
| GSE53624 | NR3C2 | 4306 | 108786 | -1.8603 | 0.0000 | |
| GSE63941 | NR3C2 | 4306 | 205259_at | -0.4973 | 0.5557 | |
| GSE77861 | NR3C2 | 4306 | 205259_at | -0.1739 | 0.2186 | |
| GSE97050 | NR3C2 | 4306 | A_23_P392470 | -1.2034 | 0.0964 | |
| SRP064894 | NR3C2 | 4306 | RNAseq | -1.6678 | 0.0000 | |
| SRP133303 | NR3C2 | 4306 | RNAseq | -2.3026 | 0.0000 | |
| SRP159526 | NR3C2 | 4306 | RNAseq | -1.3393 | 0.0138 | |
| SRP193095 | NR3C2 | 4306 | RNAseq | -1.6962 | 0.0000 | |
| SRP219564 | NR3C2 | 4306 | RNAseq | -0.5680 | 0.5912 | |
| TCGA | NR3C2 | 4306 | RNAseq | -1.5194 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by NR3C2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NR3C2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NR3C2 | 4306 | 0 | 12 | 18 | |
| GSE20123 | NR3C2 | 4306 | 0 | 12 | 18 | |
| GSE43470 | NR3C2 | 4306 | 0 | 13 | 30 | |
| GSE46452 | NR3C2 | 4306 | 1 | 36 | 22 | |
| GSE47630 | NR3C2 | 4306 | 0 | 22 | 18 | |
| GSE54993 | NR3C2 | 4306 | 10 | 0 | 60 | |
| GSE54994 | NR3C2 | 4306 | 1 | 12 | 40 | |
| GSE60625 | NR3C2 | 4306 | 0 | 1 | 10 | |
| GSE74703 | NR3C2 | 4306 | 0 | 11 | 25 | |
| GSE74704 | NR3C2 | 4306 | 0 | 7 | 13 | |
| TCGA | NR3C2 | 4306 | 12 | 32 | 52 |
Total number of gains: 24; Total number of losses: 158; Total Number of normals: 306.
Somatic mutations of NR3C2:
Generating mutation plots.
Highly correlated genes for NR3C2:
Showing top 20/1481 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NR3C2 | ANGPTL1 | 0.836208 | 5 | 0 | 5 |
| NR3C2 | C1QTNF7 | 0.79509 | 5 | 0 | 5 |
| NR3C2 | ATP1A2 | 0.788716 | 9 | 0 | 9 |
| NR3C2 | MYOCD | 0.78803 | 5 | 0 | 5 |
| NR3C2 | FXYD1 | 0.773905 | 6 | 0 | 6 |
| NR3C2 | CCDC159 | 0.771096 | 3 | 0 | 3 |
| NR3C2 | SCN7A | 0.769763 | 7 | 0 | 7 |
| NR3C2 | C3orf70 | 0.765236 | 4 | 0 | 4 |
| NR3C2 | ZBTB16 | 0.758423 | 8 | 0 | 7 |
| NR3C2 | MEOX2 | 0.758368 | 7 | 0 | 7 |
| NR3C2 | MAMDC2 | 0.755994 | 6 | 0 | 5 |
| NR3C2 | KCNMB1 | 0.750633 | 8 | 0 | 8 |
| NR3C2 | ADH1B | 0.750102 | 8 | 0 | 8 |
| NR3C2 | CHRDL1 | 0.747912 | 9 | 0 | 8 |
| NR3C2 | PRKAR2B | 0.747421 | 10 | 0 | 10 |
| NR3C2 | PDCD4 | 0.747082 | 3 | 0 | 3 |
| NR3C2 | PPP1R12B | 0.745759 | 9 | 0 | 9 |
| NR3C2 | CASQ2 | 0.742922 | 9 | 0 | 8 |
| NR3C2 | ARHGAP6 | 0.73959 | 9 | 0 | 8 |
| NR3C2 | SORBS2 | 0.736998 | 10 | 0 | 9 |
For details and further investigation, click here
