| Full name: cereblon | Alias Symbol: MRT2 | ||
| Type: protein-coding gene | Cytoband: 3p26.2 | ||
| Entrez ID: 51185 | HGNC ID: HGNC:30185 | Ensembl Gene: ENSG00000113851 | OMIM ID: 609262 |
| Drug and gene relationship at DGIdb | |||
Expression of CRBN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CRBN | 51185 | 222533_at | -0.7527 | 0.0559 | |
| GSE20347 | CRBN | 51185 | 218142_s_at | -0.5277 | 0.0004 | |
| GSE23400 | CRBN | 51185 | 218142_s_at | -0.2984 | 0.0000 | |
| GSE26886 | CRBN | 51185 | 222533_at | -0.5756 | 0.0336 | |
| GSE29001 | CRBN | 51185 | 218142_s_at | -0.6107 | 0.0036 | |
| GSE38129 | CRBN | 51185 | 218142_s_at | -0.8068 | 0.0000 | |
| GSE45670 | CRBN | 51185 | 222533_at | -0.8380 | 0.0001 | |
| GSE63941 | CRBN | 51185 | 222533_at | -0.0301 | 0.9624 | |
| GSE77861 | CRBN | 51185 | 222533_at | -0.6528 | 0.0266 | |
| GSE97050 | CRBN | 51185 | A_33_P3398401 | -0.3934 | 0.1838 | |
| SRP007169 | CRBN | 51185 | RNAseq | -0.3450 | 0.3590 | |
| SRP008496 | CRBN | 51185 | RNAseq | 0.0601 | 0.8614 | |
| SRP064894 | CRBN | 51185 | RNAseq | -0.6459 | 0.0004 | |
| SRP133303 | CRBN | 51185 | RNAseq | -0.6092 | 0.0003 | |
| SRP159526 | CRBN | 51185 | RNAseq | -0.8966 | 0.0004 | |
| SRP193095 | CRBN | 51185 | RNAseq | -0.6634 | 0.0000 | |
| SRP219564 | CRBN | 51185 | RNAseq | -0.8208 | 0.0182 | |
| TCGA | CRBN | 51185 | RNAseq | -0.3614 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CRBN expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CRBN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CRBN | 51185 | 1 | 18 | 11 | |
| GSE20123 | CRBN | 51185 | 1 | 18 | 11 | |
| GSE43470 | CRBN | 51185 | 0 | 21 | 22 | |
| GSE46452 | CRBN | 51185 | 2 | 18 | 39 | |
| GSE47630 | CRBN | 51185 | 2 | 23 | 15 | |
| GSE54993 | CRBN | 51185 | 6 | 1 | 63 | |
| GSE54994 | CRBN | 51185 | 1 | 32 | 20 | |
| GSE60625 | CRBN | 51185 | 5 | 0 | 6 | |
| GSE74703 | CRBN | 51185 | 0 | 18 | 18 | |
| GSE74704 | CRBN | 51185 | 1 | 11 | 8 | |
| TCGA | CRBN | 51185 | 3 | 67 | 26 |
Total number of gains: 22; Total number of losses: 227; Total Number of normals: 239.
Somatic mutations of CRBN:
Generating mutation plots.
Highly correlated genes for CRBN:
Showing top 20/1432 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CRBN | FBXL3 | 0.854067 | 5 | 0 | 5 |
| CRBN | ANGPTL1 | 0.839599 | 3 | 0 | 3 |
| CRBN | RAB9B | 0.833699 | 3 | 0 | 3 |
| CRBN | ICA1L | 0.821518 | 4 | 0 | 4 |
| CRBN | LRRN4CL | 0.81528 | 3 | 0 | 3 |
| CRBN | MAMDC2 | 0.812022 | 3 | 0 | 3 |
| CRBN | C1QTNF7 | 0.811351 | 3 | 0 | 3 |
| CRBN | LYSMD3 | 0.80353 | 3 | 0 | 3 |
| CRBN | KCNT2 | 0.802534 | 3 | 0 | 3 |
| CRBN | ZCCHC9 | 0.799456 | 3 | 0 | 3 |
| CRBN | KDM5D | 0.799266 | 3 | 0 | 3 |
| CRBN | PARD3B | 0.789647 | 3 | 0 | 3 |
| CRBN | INMT | 0.787145 | 3 | 0 | 3 |
| CRBN | ANO5 | 0.786011 | 3 | 0 | 3 |
| CRBN | GNPDA2 | 0.782613 | 4 | 0 | 4 |
| CRBN | NBPF1 | 0.779105 | 3 | 0 | 3 |
| CRBN | MYOCD | 0.777314 | 3 | 0 | 3 |
| CRBN | AK3 | 0.774176 | 5 | 0 | 5 |
| CRBN | EIF4E3 | 0.772076 | 5 | 0 | 5 |
| CRBN | NEGR1 | 0.767037 | 3 | 0 | 3 |
For details and further investigation, click here
