| Full name: protein phosphatase, Mg2+/Mn2+ dependent 1L | Alias Symbol: PP2CE | ||
| Type: protein-coding gene | Cytoband: 3q25.33-q26.1 | ||
| Entrez ID: 151742 | HGNC ID: HGNC:16381 | Ensembl Gene: ENSG00000163590 | OMIM ID: 611931 |
| Drug and gene relationship at DGIdb | |||
Expression of PPM1L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPM1L | 151742 | 228108_at | -1.6088 | 0.2617 | |
| GSE26886 | PPM1L | 151742 | 228108_at | -0.3678 | 0.5690 | |
| GSE45670 | PPM1L | 151742 | 228108_at | -1.4437 | 0.0051 | |
| GSE53622 | PPM1L | 151742 | 12122 | -1.5017 | 0.0000 | |
| GSE53624 | PPM1L | 151742 | 80083 | -1.5148 | 0.0000 | |
| GSE63941 | PPM1L | 151742 | 229506_at | -0.2633 | 0.7733 | |
| GSE77861 | PPM1L | 151742 | 228457_at | -0.4265 | 0.0340 | |
| GSE97050 | PPM1L | 151742 | A_23_P147563 | -1.2046 | 0.1204 | |
| SRP007169 | PPM1L | 151742 | RNAseq | -1.3511 | 0.0003 | |
| SRP008496 | PPM1L | 151742 | RNAseq | -0.9498 | 0.0005 | |
| SRP064894 | PPM1L | 151742 | RNAseq | -1.2817 | 0.0000 | |
| SRP133303 | PPM1L | 151742 | RNAseq | -0.7501 | 0.1033 | |
| SRP159526 | PPM1L | 151742 | RNAseq | -0.3313 | 0.2628 | |
| SRP193095 | PPM1L | 151742 | RNAseq | -0.6781 | 0.0026 | |
| SRP219564 | PPM1L | 151742 | RNAseq | -0.3410 | 0.5528 | |
| TCGA | PPM1L | 151742 | RNAseq | -0.4806 | 0.0107 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by PPM1L expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPM1L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPM1L | 151742 | 22 | 0 | 8 | |
| GSE20123 | PPM1L | 151742 | 22 | 0 | 8 | |
| GSE43470 | PPM1L | 151742 | 23 | 0 | 20 | |
| GSE46452 | PPM1L | 151742 | 18 | 2 | 39 | |
| GSE47630 | PPM1L | 151742 | 19 | 3 | 18 | |
| GSE54993 | PPM1L | 151742 | 1 | 11 | 58 | |
| GSE54994 | PPM1L | 151742 | 38 | 1 | 14 | |
| GSE60625 | PPM1L | 151742 | 0 | 6 | 5 | |
| GSE74703 | PPM1L | 151742 | 20 | 0 | 16 | |
| GSE74704 | PPM1L | 151742 | 14 | 0 | 6 | |
| TCGA | PPM1L | 151742 | 77 | 0 | 19 |
Total number of gains: 254; Total number of losses: 23; Total Number of normals: 211.
Somatic mutations of PPM1L:
Generating mutation plots.
Highly correlated genes for PPM1L:
Showing top 20/1240 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPM1L | PPP1R9A | 0.828842 | 4 | 0 | 4 |
| PPM1L | GPD1L | 0.802582 | 6 | 0 | 6 |
| PPM1L | PINK1 | 0.79694 | 3 | 0 | 3 |
| PPM1L | ABCA8 | 0.78409 | 5 | 0 | 5 |
| PPM1L | FOXN3 | 0.778498 | 3 | 0 | 3 |
| PPM1L | IFT81 | 0.774662 | 3 | 0 | 3 |
| PPM1L | ADH1C | 0.773735 | 5 | 0 | 5 |
| PPM1L | CLIP1 | 0.770494 | 3 | 0 | 3 |
| PPM1L | TMEM218 | 0.769558 | 3 | 0 | 3 |
| PPM1L | CNN1 | 0.764445 | 3 | 0 | 3 |
| PPM1L | SOCS6 | 0.75954 | 3 | 0 | 3 |
| PPM1L | SON | 0.757672 | 3 | 0 | 3 |
| PPM1L | CLEC3B | 0.75436 | 3 | 0 | 3 |
| PPM1L | USP38 | 0.752473 | 3 | 0 | 3 |
| PPM1L | CGNL1 | 0.748925 | 6 | 0 | 6 |
| PPM1L | HPGD | 0.747891 | 6 | 0 | 6 |
| PPM1L | FAM172A | 0.747268 | 7 | 0 | 7 |
| PPM1L | RALGPS1 | 0.746291 | 6 | 0 | 6 |
| PPM1L | MEIS1 | 0.745048 | 6 | 0 | 5 |
| PPM1L | HSPB6 | 0.744711 | 4 | 0 | 4 |
For details and further investigation, click here
