| Full name: clathrin heavy chain like 1 | Alias Symbol: CLTD|CLH22|CHC22 | ||
| Type: protein-coding gene | Cytoband: 22q11.21 | ||
| Entrez ID: 8218 | HGNC ID: HGNC:2093 | Ensembl Gene: ENSG00000070371 | OMIM ID: 601273 |
| Drug and gene relationship at DGIdb | |||
CLTCL1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05016 | Huntington's disease |
Expression of CLTCL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLTCL1 | 8218 | 205944_s_at | -0.1247 | 0.8083 | |
| GSE20347 | CLTCL1 | 8218 | 205944_s_at | -0.0739 | 0.5131 | |
| GSE23400 | CLTCL1 | 8218 | 205944_s_at | -0.0596 | 0.1921 | |
| GSE26886 | CLTCL1 | 8218 | 205944_s_at | 0.2267 | 0.1855 | |
| GSE29001 | CLTCL1 | 8218 | 205944_s_at | 0.0638 | 0.8398 | |
| GSE38129 | CLTCL1 | 8218 | 205944_s_at | -0.0600 | 0.6327 | |
| GSE45670 | CLTCL1 | 8218 | 205944_s_at | 0.1520 | 0.2093 | |
| GSE53622 | CLTCL1 | 8218 | 16203 | 0.3129 | 0.0001 | |
| GSE53624 | CLTCL1 | 8218 | 16203 | 0.0063 | 0.9529 | |
| GSE63941 | CLTCL1 | 8218 | 205944_s_at | 0.1666 | 0.7647 | |
| GSE77861 | CLTCL1 | 8218 | 205944_s_at | -0.1129 | 0.6336 | |
| GSE97050 | CLTCL1 | 8218 | A_23_P143559 | -0.1317 | 0.4968 | |
| SRP007169 | CLTCL1 | 8218 | RNAseq | 1.5768 | 0.0098 | |
| SRP064894 | CLTCL1 | 8218 | RNAseq | 1.1816 | 0.0000 | |
| SRP133303 | CLTCL1 | 8218 | RNAseq | -0.0151 | 0.9449 | |
| SRP159526 | CLTCL1 | 8218 | RNAseq | 0.8673 | 0.0472 | |
| SRP193095 | CLTCL1 | 8218 | RNAseq | 0.2034 | 0.3488 | |
| SRP219564 | CLTCL1 | 8218 | RNAseq | 0.4265 | 0.2340 | |
| TCGA | CLTCL1 | 8218 | RNAseq | 0.0732 | 0.5702 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by CLTCL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLTCL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLTCL1 | 8218 | 4 | 8 | 18 | |
| GSE20123 | CLTCL1 | 8218 | 4 | 8 | 18 | |
| GSE43470 | CLTCL1 | 8218 | 5 | 7 | 31 | |
| GSE46452 | CLTCL1 | 8218 | 33 | 1 | 25 | |
| GSE47630 | CLTCL1 | 8218 | 8 | 5 | 27 | |
| GSE54993 | CLTCL1 | 8218 | 3 | 6 | 61 | |
| GSE54994 | CLTCL1 | 8218 | 12 | 7 | 34 | |
| GSE60625 | CLTCL1 | 8218 | 5 | 0 | 6 | |
| GSE74703 | CLTCL1 | 8218 | 5 | 5 | 26 | |
| GSE74704 | CLTCL1 | 8218 | 2 | 5 | 13 | |
| TCGA | CLTCL1 | 8218 | 27 | 17 | 52 |
Total number of gains: 108; Total number of losses: 69; Total Number of normals: 311.
Somatic mutations of CLTCL1:
Generating mutation plots.
Highly correlated genes for CLTCL1:
Showing top 20/486 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLTCL1 | DCDC1 | 0.912601 | 3 | 0 | 3 |
| CLTCL1 | STRC | 0.901855 | 3 | 0 | 3 |
| CLTCL1 | GRIK4 | 0.882137 | 3 | 0 | 3 |
| CLTCL1 | SLC22A31 | 0.874518 | 3 | 0 | 3 |
| CLTCL1 | PLA2G2C | 0.872494 | 3 | 0 | 3 |
| CLTCL1 | KCP | 0.863811 | 3 | 0 | 3 |
| CLTCL1 | WDR87 | 0.856757 | 3 | 0 | 3 |
| CLTCL1 | BBC3 | 0.843321 | 3 | 0 | 3 |
| CLTCL1 | YY2 | 0.842324 | 3 | 0 | 3 |
| CLTCL1 | OR2T27 | 0.834154 | 3 | 0 | 3 |
| CLTCL1 | C1QL2 | 0.830344 | 3 | 0 | 3 |
| CLTCL1 | RNF180 | 0.820315 | 3 | 0 | 3 |
| CLTCL1 | OR2A5 | 0.81436 | 3 | 0 | 3 |
| CLTCL1 | C9orf153 | 0.810783 | 3 | 0 | 3 |
| CLTCL1 | MRGPRG | 0.806736 | 3 | 0 | 3 |
| CLTCL1 | TXNDC2 | 0.806169 | 4 | 0 | 4 |
| CLTCL1 | CA6 | 0.805035 | 3 | 0 | 3 |
| CLTCL1 | PABPN1L | 0.803735 | 3 | 0 | 3 |
| CLTCL1 | PRSS38 | 0.801755 | 3 | 0 | 3 |
| CLTCL1 | RETN | 0.798204 | 3 | 0 | 3 |
For details and further investigation, click here
