| Full name: 2',3'-cyclic nucleotide 3' phosphodiesterase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 1267 | HGNC ID: HGNC:2158 | Ensembl Gene: ENSG00000173786 | OMIM ID: 123830 |
| Drug and gene relationship at DGIdb | |||
Expression of CNP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CNP | 1267 | 208912_s_at | -0.0049 | 0.9879 | |
| GSE20347 | CNP | 1267 | 208912_s_at | -0.5221 | 0.0000 | |
| GSE23400 | CNP | 1267 | 208912_s_at | -0.1495 | 0.0003 | |
| GSE26886 | CNP | 1267 | 208912_s_at | -0.1183 | 0.4869 | |
| GSE29001 | CNP | 1267 | 208912_s_at | -0.2536 | 0.0697 | |
| GSE38129 | CNP | 1267 | 208912_s_at | -0.3744 | 0.0002 | |
| GSE45670 | CNP | 1267 | 208912_s_at | 0.0108 | 0.9539 | |
| GSE53622 | CNP | 1267 | 3830 | -0.2886 | 0.0000 | |
| GSE53624 | CNP | 1267 | 3830 | -0.2573 | 0.0000 | |
| GSE63941 | CNP | 1267 | 208912_s_at | -1.0432 | 0.0016 | |
| GSE77861 | CNP | 1267 | 208912_s_at | -0.2747 | 0.0594 | |
| GSE97050 | CNP | 1267 | A_23_P21838 | -0.0938 | 0.7261 | |
| SRP007169 | CNP | 1267 | RNAseq | -1.1404 | 0.0042 | |
| SRP008496 | CNP | 1267 | RNAseq | -1.0958 | 0.0000 | |
| SRP064894 | CNP | 1267 | RNAseq | 0.0400 | 0.8104 | |
| SRP133303 | CNP | 1267 | RNAseq | -0.3482 | 0.0165 | |
| SRP159526 | CNP | 1267 | RNAseq | -0.3353 | 0.0431 | |
| SRP193095 | CNP | 1267 | RNAseq | -0.4002 | 0.0003 | |
| SRP219564 | CNP | 1267 | RNAseq | -0.4576 | 0.0627 | |
| TCGA | CNP | 1267 | RNAseq | 0.1359 | 0.0052 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by CNP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CNP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CNP | 1267 | 6 | 2 | 22 | |
| GSE20123 | CNP | 1267 | 6 | 2 | 22 | |
| GSE43470 | CNP | 1267 | 1 | 2 | 40 | |
| GSE46452 | CNP | 1267 | 34 | 0 | 25 | |
| GSE47630 | CNP | 1267 | 8 | 1 | 31 | |
| GSE54993 | CNP | 1267 | 3 | 4 | 63 | |
| GSE54994 | CNP | 1267 | 8 | 5 | 40 | |
| GSE60625 | CNP | 1267 | 4 | 0 | 7 | |
| GSE74703 | CNP | 1267 | 1 | 1 | 34 | |
| GSE74704 | CNP | 1267 | 4 | 1 | 15 | |
| TCGA | CNP | 1267 | 23 | 6 | 67 |
Total number of gains: 98; Total number of losses: 24; Total Number of normals: 366.
Somatic mutations of CNP:
Generating mutation plots.
Highly correlated genes for CNP:
Showing top 20/772 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CNP | ZNF717 | 0.782066 | 3 | 0 | 3 |
| CNP | TMEM129 | 0.773104 | 3 | 0 | 3 |
| CNP | STAMBPL1 | 0.749654 | 3 | 0 | 3 |
| CNP | TMEM234 | 0.747731 | 3 | 0 | 3 |
| CNP | LYSMD3 | 0.747649 | 3 | 0 | 3 |
| CNP | NDUFA13 | 0.747626 | 4 | 0 | 4 |
| CNP | RAB42 | 0.730831 | 3 | 0 | 3 |
| CNP | ZNF35 | 0.728007 | 3 | 0 | 3 |
| CNP | WDR37 | 0.723557 | 3 | 0 | 3 |
| CNP | COG6 | 0.722865 | 3 | 0 | 3 |
| CNP | ARHGAP17 | 0.720709 | 5 | 0 | 4 |
| CNP | TLE2 | 0.719397 | 3 | 0 | 3 |
| CNP | SUSD1 | 0.715075 | 3 | 0 | 3 |
| CNP | SPTLC3 | 0.713595 | 3 | 0 | 3 |
| CNP | JOSD2 | 0.712963 | 3 | 0 | 3 |
| CNP | PRRC1 | 0.706191 | 3 | 0 | 3 |
| CNP | KIAA0319L | 0.704174 | 5 | 0 | 4 |
| CNP | HNRNPA3 | 0.702987 | 3 | 0 | 3 |
| CNP | TDRD3 | 0.700155 | 4 | 0 | 3 |
| CNP | MAN2B2 | 0.698976 | 5 | 0 | 5 |
For details and further investigation, click here
