CREB1

 

Full name: cAMP responsive element binding protein 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 2q33.3
Entrez ID: 1385 HGNC ID: HGNC:2345 Ensembl Gene: ENSG00000118260 OMIM ID: 123810
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

CREB1 involved pathways:

KEGG pathway Description View
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04380Osteoclast differentiation
hsa04612Antigen processing and presentation
hsa04668TNF signaling pathway
hsa04710Circadian rhythm
hsa04713Circadian entrainment
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa04911Insulin secretion
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04922Glucagon signaling pathway
hsa04924Renin secretion
hsa04925Aldosterone synthesis and secretion
hsa04931Insulin resistance
hsa04962Vasopressin-regulated water reabsorption
hsa05030Cocaine addiction
hsa05031Amphetamine addiction
hsa05034Alcoholism
hsa05152Tuberculosis
hsa05161Hepatitis B
hsa05166HTLV-I infection
hsa05215Prostate cancer

 

Expression of CREB1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CREB1 1385 225572_at 0.0379 0.9635
GSE20347 CREB1 1385 204314_s_at 0.0217 0.8968
GSE23400 CREB1 1385 204313_s_at 0.3336 0.0000
GSE26886 CREB1 1385 225572_at -0.2015 0.3372
GSE29001 CREB1 1385 204313_s_at 0.2279 0.3223
GSE38129 CREB1 1385 204314_s_at -0.0411 0.8435
GSE45670 CREB1 1385 225572_at -0.0356 0.7922
GSE53622 CREB1 1385 24452 0.0745 0.3743
GSE53624 CREB1 1385 24452 -0.0393 0.5841
GSE63941 CREB1 1385 204313_s_at 0.6966 0.0215
GSE77861 CREB1 1385 204313_s_at 0.3481 0.3206
GSE97050 CREB1 1385 A_23_P79231 -0.2608 0.2434
SRP007169 CREB1 1385 RNAseq -0.2979 0.4044
SRP008496 CREB1 1385 RNAseq -0.3328 0.1780
SRP064894 CREB1 1385 RNAseq -0.1840 0.4418
SRP133303 CREB1 1385 RNAseq 0.1445 0.2113
SRP159526 CREB1 1385 RNAseq 0.0381 0.8432
SRP193095 CREB1 1385 RNAseq 0.0589 0.5126
SRP219564 CREB1 1385 RNAseq -0.5241 0.3388
TCGA CREB1 1385 RNAseq 0.0268 0.5752

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CREB1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CREB1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CREB1 1385 3 7 20
GSE20123 CREB1 1385 3 7 20
GSE43470 CREB1 1385 2 4 37
GSE46452 CREB1 1385 1 4 54
GSE47630 CREB1 1385 4 5 31
GSE54993 CREB1 1385 0 3 67
GSE54994 CREB1 1385 8 9 36
GSE60625 CREB1 1385 0 3 8
GSE74703 CREB1 1385 2 3 31
GSE74704 CREB1 1385 2 3 15
TCGA CREB1 1385 15 21 60

Total number of gains: 40; Total number of losses: 69; Total Number of normals: 379.  

 

Somatic mutations of CREB1:

 

Generating mutation plots.

 

Highly correlated genes for CREB1:

 

Showing top 20/326 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CREB1RPL7L10.771376303
CREB1COCH0.769227303
CREB1REEP30.769138303
CREB1DICER10.761812303
CREB1ZNF5570.760956303
CREB1ITGB80.744809303
CREB1NAA300.742461303
CREB1FBXO330.728789303
CREB1SYAP10.724847303
CREB1COG30.719998303
CREB1ZNF6490.715525303
CREB1WTAP0.715138404
CREB1TMEM2050.713262404
CREB1PIP4K2C0.712194303
CREB1ATP8B10.710846303
CREB1ZNF5660.707965303
CREB1ZNF3830.706877303
CREB1FARSA0.70499303
CREB1TADA10.704022303
CREB1ZFP900.701283303

For details and further investigation, click here