| Full name: cochlin | Alias Symbol: COCH-5B2 | ||
| Type: protein-coding gene | Cytoband: 14q12 | ||
| Entrez ID: 1690 | HGNC ID: HGNC:2180 | Ensembl Gene: ENSG00000100473 | OMIM ID: 603196 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of COCH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COCH | 1690 | 1554241_at | 0.6339 | 0.3837 | |
| GSE20347 | COCH | 1690 | 205229_s_at | 1.2129 | 0.0023 | |
| GSE23400 | COCH | 1690 | 205229_s_at | 0.3158 | 0.0044 | |
| GSE26886 | COCH | 1690 | 1554241_at | 1.2191 | 0.0038 | |
| GSE29001 | COCH | 1690 | 205229_s_at | 1.4205 | 0.0225 | |
| GSE38129 | COCH | 1690 | 205229_s_at | 1.2545 | 0.0003 | |
| GSE45670 | COCH | 1690 | 1554241_at | 0.7522 | 0.0006 | |
| GSE53622 | COCH | 1690 | 26858 | 1.1203 | 0.0001 | |
| GSE53624 | COCH | 1690 | 26858 | 1.5765 | 0.0000 | |
| GSE63941 | COCH | 1690 | 1554241_at | 2.7708 | 0.0005 | |
| GSE77861 | COCH | 1690 | 1554241_at | 1.3060 | 0.0005 | |
| GSE97050 | COCH | 1690 | A_24_P184799 | -0.0760 | 0.7778 | |
| SRP133303 | COCH | 1690 | RNAseq | 1.5218 | 0.0073 | |
| SRP159526 | COCH | 1690 | RNAseq | 3.3989 | 0.0000 | |
| TCGA | COCH | 1690 | RNAseq | 1.1058 | 0.0022 |
Upregulated datasets: 11; Downregulated datasets: 0.
Survival by COCH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COCH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COCH | 1690 | 8 | 4 | 18 | |
| GSE20123 | COCH | 1690 | 8 | 4 | 18 | |
| GSE43470 | COCH | 1690 | 10 | 2 | 31 | |
| GSE46452 | COCH | 1690 | 16 | 2 | 41 | |
| GSE47630 | COCH | 1690 | 11 | 10 | 19 | |
| GSE54993 | COCH | 1690 | 3 | 11 | 56 | |
| GSE54994 | COCH | 1690 | 19 | 5 | 29 | |
| GSE60625 | COCH | 1690 | 0 | 2 | 9 | |
| GSE74703 | COCH | 1690 | 9 | 2 | 25 | |
| GSE74704 | COCH | 1690 | 3 | 3 | 14 | |
| TCGA | COCH | 1690 | 32 | 14 | 50 |
Total number of gains: 119; Total number of losses: 59; Total Number of normals: 310.
Somatic mutations of COCH:
Generating mutation plots.
Highly correlated genes for COCH:
Showing top 20/1286 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COCH | YWHAG | 0.804822 | 5 | 0 | 5 |
| COCH | CRK | 0.783273 | 3 | 0 | 3 |
| COCH | ANAPC4 | 0.782616 | 3 | 0 | 3 |
| COCH | CWC22 | 0.781839 | 3 | 0 | 3 |
| COCH | CMTM4 | 0.781429 | 4 | 0 | 4 |
| COCH | CDC73 | 0.771563 | 3 | 0 | 3 |
| COCH | RICTOR | 0.770882 | 3 | 0 | 3 |
| COCH | CREB1 | 0.769227 | 3 | 0 | 3 |
| COCH | VEZT | 0.767002 | 3 | 0 | 3 |
| COCH | SENP1 | 0.76507 | 3 | 0 | 3 |
| COCH | ZBTB8OS | 0.76039 | 3 | 0 | 3 |
| COCH | UEVLD | 0.758567 | 3 | 0 | 3 |
| COCH | TMEM205 | 0.757782 | 3 | 0 | 3 |
| COCH | PACSIN3 | 0.75535 | 3 | 0 | 3 |
| COCH | WDR81 | 0.751293 | 3 | 0 | 3 |
| COCH | IWS1 | 0.746991 | 5 | 0 | 4 |
| COCH | AMMECR1L | 0.74422 | 5 | 0 | 5 |
| COCH | ZNF544 | 0.737362 | 3 | 0 | 3 |
| COCH | TIGD1 | 0.736416 | 5 | 0 | 5 |
| COCH | KTN1 | 0.731243 | 5 | 0 | 5 |
For details and further investigation, click here
