| Full name: ATPase phospholipid transporting 8B1 | Alias Symbol: ATPIC|PFIC | ||
| Type: protein-coding gene | Cytoband: 18q21.31 | ||
| Entrez ID: 5205 | HGNC ID: HGNC:3706 | Ensembl Gene: ENSG00000081923 | OMIM ID: 602397 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ATP8B1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ATP8B1 | 5205 | 226302_at | -0.1409 | 0.9088 | |
| GSE20347 | ATP8B1 | 5205 | 214594_x_at | 0.4272 | 0.1206 | |
| GSE23400 | ATP8B1 | 5205 | 214594_x_at | -0.0550 | 0.6571 | |
| GSE26886 | ATP8B1 | 5205 | 226302_at | -1.5194 | 0.0001 | |
| GSE29001 | ATP8B1 | 5205 | 214594_x_at | 0.3728 | 0.0329 | |
| GSE38129 | ATP8B1 | 5205 | 214594_x_at | 0.1012 | 0.8040 | |
| GSE45670 | ATP8B1 | 5205 | 226302_at | -0.0877 | 0.7349 | |
| GSE53622 | ATP8B1 | 5205 | 7530 | -0.9562 | 0.0000 | |
| GSE53624 | ATP8B1 | 5205 | 7530 | -0.9413 | 0.0000 | |
| GSE63941 | ATP8B1 | 5205 | 226302_at | 0.0400 | 0.9734 | |
| GSE77861 | ATP8B1 | 5205 | 214594_x_at | 0.8739 | 0.1360 | |
| GSE97050 | ATP8B1 | 5205 | A_33_P3415191 | -0.2504 | 0.4236 | |
| SRP007169 | ATP8B1 | 5205 | RNAseq | -1.0545 | 0.0196 | |
| SRP008496 | ATP8B1 | 5205 | RNAseq | -0.9561 | 0.0006 | |
| SRP064894 | ATP8B1 | 5205 | RNAseq | -0.8876 | 0.0010 | |
| SRP133303 | ATP8B1 | 5205 | RNAseq | -0.4327 | 0.1016 | |
| SRP159526 | ATP8B1 | 5205 | RNAseq | -0.2903 | 0.6094 | |
| SRP193095 | ATP8B1 | 5205 | RNAseq | -0.9579 | 0.0000 | |
| SRP219564 | ATP8B1 | 5205 | RNAseq | -0.7780 | 0.1599 | |
| TCGA | ATP8B1 | 5205 | RNAseq | -0.4365 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by ATP8B1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ATP8B1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ATP8B1 | 5205 | 2 | 9 | 19 | |
| GSE20123 | ATP8B1 | 5205 | 2 | 9 | 19 | |
| GSE43470 | ATP8B1 | 5205 | 0 | 5 | 38 | |
| GSE46452 | ATP8B1 | 5205 | 1 | 26 | 32 | |
| GSE47630 | ATP8B1 | 5205 | 5 | 20 | 15 | |
| GSE54993 | ATP8B1 | 5205 | 10 | 0 | 60 | |
| GSE54994 | ATP8B1 | 5205 | 0 | 18 | 35 | |
| GSE60625 | ATP8B1 | 5205 | 0 | 4 | 7 | |
| GSE74703 | ATP8B1 | 5205 | 0 | 5 | 31 | |
| GSE74704 | ATP8B1 | 5205 | 2 | 6 | 12 | |
| TCGA | ATP8B1 | 5205 | 9 | 44 | 43 |
Total number of gains: 31; Total number of losses: 146; Total Number of normals: 311.
Somatic mutations of ATP8B1:
Generating mutation plots.
Highly correlated genes for ATP8B1:
Showing top 20/320 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ATP8B1 | USP34 | 0.808081 | 6 | 0 | 5 |
| ATP8B1 | ZNF292 | 0.806865 | 3 | 0 | 3 |
| ATP8B1 | NAA25 | 0.806427 | 3 | 0 | 3 |
| ATP8B1 | PRPF38A | 0.780919 | 3 | 0 | 3 |
| ATP8B1 | ZFC3H1 | 0.774207 | 4 | 0 | 4 |
| ATP8B1 | SPAST | 0.761312 | 3 | 0 | 3 |
| ATP8B1 | KLHL29 | 0.756981 | 3 | 0 | 3 |
| ATP8B1 | ASH2L | 0.748281 | 3 | 0 | 3 |
| ATP8B1 | RECK | 0.745973 | 4 | 0 | 4 |
| ATP8B1 | AP3M1 | 0.743883 | 3 | 0 | 3 |
| ATP8B1 | MSL3 | 0.736562 | 3 | 0 | 3 |
| ATP8B1 | TBC1D15 | 0.729957 | 3 | 0 | 3 |
| ATP8B1 | SLC10A5 | 0.720133 | 3 | 0 | 3 |
| ATP8B1 | SCNN1A | 0.719168 | 4 | 0 | 4 |
| ATP8B1 | CREB1 | 0.710846 | 3 | 0 | 3 |
| ATP8B1 | TAB3 | 0.710827 | 5 | 0 | 4 |
| ATP8B1 | SLTM | 0.710302 | 3 | 0 | 3 |
| ATP8B1 | IFT46 | 0.71011 | 3 | 0 | 3 |
| ATP8B1 | MKNK2 | 0.707252 | 3 | 0 | 3 |
| ATP8B1 | FAM83D | 0.698413 | 3 | 0 | 3 |
For details and further investigation, click here
