| Full name: integrin subunit beta 8 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 7p21.1 | ||
| Entrez ID: 3696 | HGNC ID: HGNC:6163 | Ensembl Gene: ENSG00000105855 | OMIM ID: 604160 |
| Drug and gene relationship at DGIdb | |||
ITGB8 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion | |
| hsa04810 | Regulation of actin cytoskeleton |
Expression of ITGB8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ITGB8 | 3696 | 226189_at | 0.5757 | 0.3685 | |
| GSE20347 | ITGB8 | 3696 | 211488_s_at | 0.0549 | 0.7573 | |
| GSE23400 | ITGB8 | 3696 | 211488_s_at | -0.0487 | 0.3852 | |
| GSE26886 | ITGB8 | 3696 | 226189_at | 0.9166 | 0.0068 | |
| GSE29001 | ITGB8 | 3696 | 205816_at | -0.2181 | 0.6005 | |
| GSE38129 | ITGB8 | 3696 | 205816_at | 0.2850 | 0.3067 | |
| GSE45670 | ITGB8 | 3696 | 226189_at | 0.3460 | 0.1703 | |
| GSE63941 | ITGB8 | 3696 | 226189_at | -0.1792 | 0.8921 | |
| GSE77861 | ITGB8 | 3696 | 226189_at | 0.5060 | 0.1006 | |
| GSE97050 | ITGB8 | 3696 | A_24_P759477 | 0.3817 | 0.2991 | |
| SRP007169 | ITGB8 | 3696 | RNAseq | -0.2712 | 0.5038 | |
| SRP008496 | ITGB8 | 3696 | RNAseq | 0.1941 | 0.4413 | |
| SRP064894 | ITGB8 | 3696 | RNAseq | -0.4418 | 0.1625 | |
| SRP133303 | ITGB8 | 3696 | RNAseq | 0.8723 | 0.0001 | |
| SRP159526 | ITGB8 | 3696 | RNAseq | 0.4154 | 0.2710 | |
| SRP193095 | ITGB8 | 3696 | RNAseq | 0.5582 | 0.0210 | |
| SRP219564 | ITGB8 | 3696 | RNAseq | 0.7172 | 0.1996 | |
| TCGA | ITGB8 | 3696 | RNAseq | 0.5008 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ITGB8 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ITGB8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ITGB8 | 3696 | 16 | 2 | 12 | |
| GSE20123 | ITGB8 | 3696 | 16 | 2 | 12 | |
| GSE43470 | ITGB8 | 3696 | 4 | 0 | 39 | |
| GSE46452 | ITGB8 | 3696 | 10 | 2 | 47 | |
| GSE47630 | ITGB8 | 3696 | 9 | 1 | 30 | |
| GSE54993 | ITGB8 | 3696 | 0 | 6 | 64 | |
| GSE54994 | ITGB8 | 3696 | 20 | 2 | 31 | |
| GSE60625 | ITGB8 | 3696 | 0 | 0 | 11 | |
| GSE74703 | ITGB8 | 3696 | 4 | 0 | 32 | |
| GSE74704 | ITGB8 | 3696 | 10 | 2 | 8 | |
| TCGA | ITGB8 | 3696 | 56 | 5 | 35 |
Total number of gains: 145; Total number of losses: 22; Total Number of normals: 321.
Somatic mutations of ITGB8:
Generating mutation plots.
Highly correlated genes for ITGB8:
Showing top 20/371 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ITGB8 | FKTN | 0.831056 | 3 | 0 | 3 |
| ITGB8 | AAGAB | 0.815185 | 3 | 0 | 3 |
| ITGB8 | PHTF2 | 0.784268 | 4 | 0 | 4 |
| ITGB8 | CLSTN1 | 0.767081 | 3 | 0 | 3 |
| ITGB8 | CPSF3 | 0.760942 | 4 | 0 | 4 |
| ITGB8 | LRRC59 | 0.760672 | 3 | 0 | 3 |
| ITGB8 | UBTD2 | 0.75421 | 3 | 0 | 3 |
| ITGB8 | A4GALT | 0.753067 | 3 | 0 | 3 |
| ITGB8 | BAD | 0.750774 | 3 | 0 | 3 |
| ITGB8 | LRIF1 | 0.747787 | 4 | 0 | 3 |
| ITGB8 | USP39 | 0.746183 | 3 | 0 | 3 |
| ITGB8 | CD44 | 0.745421 | 3 | 0 | 3 |
| ITGB8 | CREB1 | 0.744809 | 3 | 0 | 3 |
| ITGB8 | PAK2 | 0.739709 | 4 | 0 | 4 |
| ITGB8 | SPNS1 | 0.734951 | 3 | 0 | 3 |
| ITGB8 | GTPBP3 | 0.728118 | 3 | 0 | 3 |
| ITGB8 | PHKG2 | 0.728062 | 3 | 0 | 3 |
| ITGB8 | GMCL1 | 0.727794 | 4 | 0 | 4 |
| ITGB8 | CPT1A | 0.727566 | 3 | 0 | 3 |
| ITGB8 | FAM171B | 0.723862 | 3 | 0 | 3 |
For details and further investigation, click here
