DICER1

 

Full name: dicer 1, ribonuclease III Alias Symbol: Dicer|KIAA0928|K12H4.8-LIKE|HERNA
Type: protein-coding gene Cytoband: 14q32.13
Entrez ID: 23405 HGNC ID: HGNC:17098 Ensembl Gene: ENSG00000100697 OMIM ID: 606241
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 37/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of DICER1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DICER1 23405 213229_at -0.1092 0.8932
GSE20347 DICER1 23405 213229_at -0.0310 0.8827
GSE23400 DICER1 23405 213229_at -0.3371 0.0055
GSE26886 DICER1 23405 213229_at -0.4216 0.1174
GSE29001 DICER1 23405 213229_at -0.0136 0.9612
GSE38129 DICER1 23405 213229_at -0.0429 0.9460
GSE45670 DICER1 23405 212888_at -0.0930 0.3821
GSE53622 DICER1 23405 24508 -0.2353 0.0014
GSE53624 DICER1 23405 51796 -0.3701 0.0000
GSE63941 DICER1 23405 213229_at 2.5306 0.0001
GSE77861 DICER1 23405 213229_at 0.2236 0.5503
GSE97050 DICER1 23405 A_33_P3212490 -0.3241 0.3077
SRP007169 DICER1 23405 RNAseq 0.7950 0.0836
SRP008496 DICER1 23405 RNAseq 0.5703 0.0328
SRP064894 DICER1 23405 RNAseq -0.2993 0.2779
SRP133303 DICER1 23405 RNAseq 0.0856 0.4871
SRP159526 DICER1 23405 RNAseq -0.3606 0.0128
SRP193095 DICER1 23405 RNAseq -0.1384 0.1783
SRP219564 DICER1 23405 RNAseq -0.0460 0.8998
TCGA DICER1 23405 RNAseq -0.0294 0.5538

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by DICER1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DICER1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DICER1 23405 10 4 16
GSE20123 DICER1 23405 10 3 17
GSE43470 DICER1 23405 8 3 32
GSE46452 DICER1 23405 16 3 40
GSE47630 DICER1 23405 11 8 21
GSE54993 DICER1 23405 3 8 59
GSE54994 DICER1 23405 21 4 28
GSE60625 DICER1 23405 0 2 9
GSE74703 DICER1 23405 6 3 27
GSE74704 DICER1 23405 6 3 11
TCGA DICER1 23405 30 19 47

Total number of gains: 121; Total number of losses: 60; Total Number of normals: 307.  

 

Somatic mutations of DICER1:

 

Generating mutation plots.

 

Highly correlated genes for DICER1:

 

Showing top 20/246 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DICER1PLEKHH10.859912303
DICER1TADA10.802654303
DICER1FCF10.774238504
DICER1C6orf1410.763794303
DICER1CREB10.761812303
DICER1ZNF5660.74236303
DICER1CLMN0.742001303
DICER1UCHL50.741364303
DICER1OXNAD10.741295303
DICER1METTL30.738587303
DICER1FRAS10.735797303
DICER1CCDC150.734998303
DICER1BLOC1S10.73281303
DICER1SFMBT10.730874303
DICER1GRHL20.727663303
DICER1WIPI20.724264404
DICER1ZNF7210.717654404
DICER1SPRYD40.717521303
DICER1BORA0.716562303
DICER1NOL80.715898303

For details and further investigation, click here