| Full name: component of oligomeric golgi complex 3 | Alias Symbol: SEC34 | ||
| Type: protein-coding gene | Cytoband: 13q14.13 | ||
| Entrez ID: 83548 | HGNC ID: HGNC:18619 | Ensembl Gene: ENSG00000136152 | OMIM ID: 606975 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of COG3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COG3 | 83548 | 223450_s_at | -0.0860 | 0.8572 | |
| GSE26886 | COG3 | 83548 | 223450_s_at | -0.8477 | 0.0355 | |
| GSE45670 | COG3 | 83548 | 223450_s_at | -0.0821 | 0.5999 | |
| GSE53622 | COG3 | 83548 | 19788 | -0.0907 | 0.0556 | |
| GSE53624 | COG3 | 83548 | 19788 | 0.0068 | 0.9320 | |
| GSE63941 | COG3 | 83548 | 223450_s_at | -0.3839 | 0.3788 | |
| GSE77861 | COG3 | 83548 | 223450_s_at | -0.1169 | 0.4950 | |
| GSE97050 | COG3 | 83548 | A_24_P296070 | 0.1289 | 0.6706 | |
| SRP007169 | COG3 | 83548 | RNAseq | -0.3310 | 0.4487 | |
| SRP008496 | COG3 | 83548 | RNAseq | -0.3663 | 0.1518 | |
| SRP064894 | COG3 | 83548 | RNAseq | -0.1963 | 0.3235 | |
| SRP133303 | COG3 | 83548 | RNAseq | -0.3978 | 0.0173 | |
| SRP159526 | COG3 | 83548 | RNAseq | -0.9759 | 0.0000 | |
| SRP193095 | COG3 | 83548 | RNAseq | -0.5180 | 0.0001 | |
| SRP219564 | COG3 | 83548 | RNAseq | -0.3907 | 0.2275 | |
| TCGA | COG3 | 83548 | RNAseq | -0.2169 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by COG3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COG3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COG3 | 83548 | 0 | 13 | 17 | |
| GSE20123 | COG3 | 83548 | 0 | 12 | 18 | |
| GSE43470 | COG3 | 83548 | 3 | 13 | 27 | |
| GSE46452 | COG3 | 83548 | 0 | 33 | 26 | |
| GSE47630 | COG3 | 83548 | 2 | 27 | 11 | |
| GSE54993 | COG3 | 83548 | 12 | 2 | 56 | |
| GSE54994 | COG3 | 83548 | 1 | 16 | 36 | |
| GSE60625 | COG3 | 83548 | 0 | 3 | 8 | |
| GSE74703 | COG3 | 83548 | 3 | 10 | 23 | |
| GSE74704 | COG3 | 83548 | 0 | 9 | 11 | |
| TCGA | COG3 | 83548 | 8 | 39 | 49 |
Total number of gains: 29; Total number of losses: 177; Total Number of normals: 282.
Somatic mutations of COG3:
Generating mutation plots.
Highly correlated genes for COG3:
Showing top 20/256 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COG3 | RIOK2 | 0.813658 | 3 | 0 | 3 |
| COG3 | TADA1 | 0.808626 | 3 | 0 | 3 |
| COG3 | PIGM | 0.805237 | 3 | 0 | 3 |
| COG3 | NCOA2 | 0.799303 | 3 | 0 | 3 |
| COG3 | PFKL | 0.78337 | 3 | 0 | 3 |
| COG3 | EBPL | 0.779584 | 4 | 0 | 4 |
| COG3 | DECR1 | 0.77813 | 3 | 0 | 3 |
| COG3 | RAP1GDS1 | 0.76304 | 3 | 0 | 3 |
| COG3 | ZNF268 | 0.759878 | 3 | 0 | 3 |
| COG3 | ZNF274 | 0.759071 | 4 | 0 | 4 |
| COG3 | PRKAB1 | 0.751687 | 3 | 0 | 3 |
| COG3 | ZSCAN16 | 0.74828 | 3 | 0 | 3 |
| COG3 | WWP1 | 0.747934 | 3 | 0 | 3 |
| COG3 | ACVR2A | 0.743659 | 3 | 0 | 3 |
| COG3 | ZNF566 | 0.743155 | 3 | 0 | 3 |
| COG3 | ABI1 | 0.740237 | 3 | 0 | 3 |
| COG3 | AP1M2 | 0.736068 | 3 | 0 | 3 |
| COG3 | KRTAP19-2 | 0.735182 | 3 | 0 | 3 |
| COG3 | KIAA2026 | 0.730593 | 3 | 0 | 3 |
| COG3 | ZFYVE16 | 0.726113 | 3 | 0 | 3 |
For details and further investigation, click here
