| Full name: crystallin beta B3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 22q11.23 | ||
| Entrez ID: 1417 | HGNC ID: HGNC:2400 | Ensembl Gene: ENSG00000100053 | OMIM ID: 123630 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of CRYBB3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CRYBB3 | 1417 | 207685_at | 0.0231 | 0.9422 | |
| GSE20347 | CRYBB3 | 1417 | 207685_at | 0.0470 | 0.6073 | |
| GSE23400 | CRYBB3 | 1417 | 207685_at | -0.0080 | 0.8668 | |
| GSE26886 | CRYBB3 | 1417 | 207685_at | 0.1876 | 0.1301 | |
| GSE29001 | CRYBB3 | 1417 | 207685_at | 0.0754 | 0.7071 | |
| GSE38129 | CRYBB3 | 1417 | 207685_at | 0.0184 | 0.8489 | |
| GSE45670 | CRYBB3 | 1417 | 207685_at | 0.1410 | 0.1404 | |
| GSE53622 | CRYBB3 | 1417 | 39558 | -0.8388 | 0.0000 | |
| GSE53624 | CRYBB3 | 1417 | 39558 | -0.8072 | 0.0000 | |
| GSE63941 | CRYBB3 | 1417 | 207685_at | 0.2432 | 0.2086 | |
| GSE77861 | CRYBB3 | 1417 | 207685_at | -0.1125 | 0.3194 | |
| GSE97050 | CRYBB3 | 1417 | A_24_P359441 | -0.3171 | 0.2938 | |
| SRP133303 | CRYBB3 | 1417 | RNAseq | -0.7554 | 0.0263 | |
| SRP159526 | CRYBB3 | 1417 | RNAseq | 1.4239 | 0.0012 | |
| SRP219564 | CRYBB3 | 1417 | RNAseq | 0.8010 | 0.1858 | |
| TCGA | CRYBB3 | 1417 | RNAseq | 1.9570 | 0.0006 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by CRYBB3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CRYBB3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CRYBB3 | 1417 | 4 | 6 | 20 | |
| GSE20123 | CRYBB3 | 1417 | 4 | 5 | 21 | |
| GSE43470 | CRYBB3 | 1417 | 3 | 5 | 35 | |
| GSE46452 | CRYBB3 | 1417 | 31 | 1 | 27 | |
| GSE47630 | CRYBB3 | 1417 | 8 | 5 | 27 | |
| GSE54993 | CRYBB3 | 1417 | 3 | 6 | 61 | |
| GSE54994 | CRYBB3 | 1417 | 11 | 7 | 35 | |
| GSE60625 | CRYBB3 | 1417 | 5 | 0 | 6 | |
| GSE74703 | CRYBB3 | 1417 | 3 | 4 | 29 | |
| GSE74704 | CRYBB3 | 1417 | 1 | 3 | 16 | |
| TCGA | CRYBB3 | 1417 | 26 | 14 | 56 |
Total number of gains: 99; Total number of losses: 56; Total Number of normals: 333.
Somatic mutations of CRYBB3:
Generating mutation plots.
Highly correlated genes for CRYBB3:
Showing top 20/605 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CRYBB3 | BARHL2 | 0.844545 | 3 | 0 | 3 |
| CRYBB3 | BTBD9 | 0.81807 | 3 | 0 | 3 |
| CRYBB3 | RNF222 | 0.807341 | 3 | 0 | 3 |
| CRYBB3 | NOTO | 0.802521 | 3 | 0 | 3 |
| CRYBB3 | IGLON5 | 0.787531 | 3 | 0 | 3 |
| CRYBB3 | MFSD2B | 0.779641 | 3 | 0 | 3 |
| CRYBB3 | CIB3 | 0.765922 | 3 | 0 | 3 |
| CRYBB3 | FAM163B | 0.764828 | 3 | 0 | 3 |
| CRYBB3 | CLEC18C | 0.76463 | 3 | 0 | 3 |
| CRYBB3 | COL20A1 | 0.76327 | 4 | 0 | 4 |
| CRYBB3 | LY6H | 0.752216 | 3 | 0 | 3 |
| CRYBB3 | ADAMTSL4 | 0.74739 | 3 | 0 | 3 |
| CRYBB3 | PATE3 | 0.742947 | 3 | 0 | 3 |
| CRYBB3 | KBTBD13 | 0.742384 | 3 | 0 | 3 |
| CRYBB3 | OR2Z1 | 0.74126 | 3 | 0 | 3 |
| CRYBB3 | DCD | 0.735672 | 5 | 0 | 5 |
| CRYBB3 | POM121L12 | 0.727063 | 3 | 0 | 3 |
| CRYBB3 | KIRREL2 | 0.726636 | 3 | 0 | 3 |
| CRYBB3 | CCDC166 | 0.725061 | 3 | 0 | 3 |
| CRYBB3 | KRTAP20-1 | 0.724913 | 3 | 0 | 3 |
For details and further investigation, click here
