| Full name: notochord homeobox | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p13.2 | ||
| Entrez ID: 344022 | HGNC ID: HGNC:31839 | Ensembl Gene: ENSG00000214513 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of NOTO:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | NOTO | 344022 | 132712 | -0.7788 | 0.0000 | |
| GSE53624 | NOTO | 344022 | 132712 | -1.0871 | 0.0000 | |
| GSE97050 | NOTO | 344022 | A_33_P3264771 | -0.1201 | 0.6011 | |
| SRP133303 | NOTO | 344022 | RNAseq | 0.3222 | 0.0540 | |
| TCGA | NOTO | 344022 | RNAseq | 0.5969 | 0.6577 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by NOTO expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NOTO:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NOTO | 344022 | 11 | 1 | 18 | |
| GSE20123 | NOTO | 344022 | 11 | 1 | 18 | |
| GSE43470 | NOTO | 344022 | 4 | 0 | 39 | |
| GSE46452 | NOTO | 344022 | 2 | 3 | 54 | |
| GSE47630 | NOTO | 344022 | 7 | 0 | 33 | |
| GSE54993 | NOTO | 344022 | 0 | 6 | 64 | |
| GSE54994 | NOTO | 344022 | 11 | 0 | 42 | |
| GSE60625 | NOTO | 344022 | 0 | 3 | 8 | |
| GSE74703 | NOTO | 344022 | 4 | 0 | 32 | |
| GSE74704 | NOTO | 344022 | 9 | 0 | 11 | |
| TCGA | NOTO | 344022 | 38 | 2 | 56 |
Total number of gains: 97; Total number of losses: 16; Total Number of normals: 375.
Somatic mutations of NOTO:
Generating mutation plots.
Highly correlated genes for NOTO:
Showing top 20/252 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NOTO | DCD | 0.875772 | 3 | 0 | 3 |
| NOTO | KLK2 | 0.870788 | 3 | 0 | 3 |
| NOTO | KCNA7 | 0.870069 | 3 | 0 | 3 |
| NOTO | RNF222 | 0.865959 | 3 | 0 | 3 |
| NOTO | ATP2B3 | 0.838876 | 3 | 0 | 3 |
| NOTO | BTBD9 | 0.825266 | 3 | 0 | 3 |
| NOTO | HMGB4 | 0.817071 | 3 | 0 | 3 |
| NOTO | GPR62 | 0.816285 | 3 | 0 | 3 |
| NOTO | BARHL2 | 0.809674 | 3 | 0 | 3 |
| NOTO | HAMP | 0.806016 | 3 | 0 | 3 |
| NOTO | CLEC18C | 0.804374 | 3 | 0 | 3 |
| NOTO | CRYBB3 | 0.802521 | 3 | 0 | 3 |
| NOTO | PHLDB3 | 0.794687 | 3 | 0 | 3 |
| NOTO | GPATCH3 | 0.793482 | 3 | 0 | 3 |
| NOTO | MAFG | 0.776598 | 3 | 0 | 3 |
| NOTO | SLC13A4 | 0.769959 | 3 | 0 | 3 |
| NOTO | COL20A1 | 0.76791 | 3 | 0 | 3 |
| NOTO | CAPN10 | 0.76626 | 3 | 0 | 3 |
| NOTO | SEMA3F | 0.762401 | 3 | 0 | 3 |
| NOTO | GPHB5 | 0.760538 | 3 | 0 | 3 |
For details and further investigation, click here
